Gene: Ednra

Basic information

Tag Content
Uniprot ID A0A0G2JSX5
Entrez ID 24326
Genbank protein ID
Genbank nucleotide ID NM_012550.2; XM_008772471.1;
Ensembl protein ID ENSRNOP00000054967; ENSRNOP00000071866;
Ensembl nucleotide ID ENSRNOG00000012721
Gene name Endothelin-1 receptor
Gene symbol Ednra
Organism Rattus norvegicus
NCBI taxa ID 10116
Cleft type
Developmental stage
Data sources Homology search
Reference
Functional description
Sequence
MGVLCFLASF WLALVGGAIA DNAERYSANL SSHVEDFTPF PGTEFDFLGT TLRPPNLALP 60
SNGSMHGYCP QQTKITTAFK YINTVISCTI FIVGMVGNAT LLRIIYQNKC MRNGPNALIA 120
SLALGDLIYV VIDLPINVFK LLAGRWPFDH NDFGVFLCKL FPFLQKSSVG ITVLNLCALS 180
VDRYRAVASW SRVQGIGIPL ITAIEIVSIW ILSFILAIPE AIGFVMVPFE YKGEQHRTCM 240
LNATTKFMEF YQDVKDWWLF GFYFCMPLVC TAIFYTLMTC EMLNRRNGSL RIALSEHLKQ 300
RREVAKTVFC LVVIFALCWF PLHLSRILKK TVYDEMDKNR CELLSFLLLM DYIGINLATM 360
NSCINPIALY FVSKKFKNCF QSCLCCCCHQ SKSLMTSVPM NGTSIQWKNQ EQNHNTERSS 420
HKDSMN 426

Abbreviation :
CLO : cleft lip only. CPO : cleft palate only. CLP : cleft lip and palate. CL/P : cleft lip with/without cleft palate.
For humans: CL/P, CLO, CPO, and CLP. For mice: CLO, CLP, and CPO.

Protein disorder information

Orthologous information

Relation Gene symbol Entrez ID UniProt ID Cleft type Developmental stage Species Evidence Details
1:1 orthologEDNRA281749P21450Bos taurusPredictionMore>>
1:1 orthologEDNRA450187Q5J7U3Canis lupus familiarisPredictionMore>>
1:1 orthologEDNRA102174144A0A452FAQ5Capra hircusPredictionMore>>
1:1 orthologEDNRA100062644A0A3Q2HSI2Equus caballusPredictionMore>>
1:1 orthologEDNRA1909P25101Homo sapiensPredictionMore>>
1:1 orthologEdnra13617Q61614CPOMus musculusPublicationMore>>
1:1 orthologEDNRA461530H2QQ94Pan troglodytesPredictionMore>>
1:1 orthologEDNRAF1RS70Sus scrofaPredictionMore>>
1:1 orthologednrA100126073A5A8K3Oryctolagus cuniculusPredictionMore>>
1:1 orthologEdnra24326A0A0G2JSX5Rattus norvegicusPredictionMore>>

Gene ontology

GO ID GO Term
GO:0016021 integral component of membrane
GO:0004962 endothelin receptor activity
GO:0007193 adenylate cyclase-inhibiting G protein-coupled receptor signaling pathway
GO:0014824 artery smooth muscle contraction
GO:0001569 branching involved in blood vessel morphogenesis
GO:0048484 enteric nervous system development
GO:0060322 head development
GO:0007507 heart development
GO:0001701 in utero embryonic development
GO:0014032 neural crest cell development
GO:0008217 regulation of blood pressure
GO:0010827 regulation of glucose transmembrane transport
GO:0007585 respiratory gaseous exchange by respiratory system
GO:0001666 response to hypoxia

Functional annotations

Keywords

Keyword ID Keyword Term
KW-0297 G-protein coupled receptor
KW-0472 Membrane
KW-0675 Receptor
KW-1185 Reference proteome
KW-0732 Signal
KW-0807 Transducer
KW-0812 Transmembrane
KW-1133 Transmembrane helix

Interpro

InterPro ID InterPro Term
IPR000499 Endthln_rcpt
IPR002175 ETA_rcpt
IPR000276 GPCR_Rhodpsn
IPR017452 GPCR_Rhodpsn_7TM

PROSITE

PROSITE ID PROSITE Term
PS00237 G_PROTEIN_RECEP_F1_1
PS50262 G_PROTEIN_RECEP_F1_2

Pfam

Pfam ID Pfam Term
PF00001 7tm_1