| Tag | Content |
|---|---|
| Uniprot ID | P21450; A3KMY5; A5PK08; |
| Entrez ID | 281749 |
| Genbank protein ID | AAI42310.1; CAA40917.1; AAI33408.1; |
| Genbank nucleotide ID | NM_174308.2 |
| Ensembl protein ID | ENSBTAP00000018173 |
| Ensembl nucleotide ID | ENSBTAG00000013674 |
| Gene name | Endothelin-1 receptor |
| Gene symbol | EDNRA |
| Organism | Bos taurus |
| NCBI taxa ID | 9913 |
| Cleft type | |
| Developmental stage | |
| Data sources | Homology search |
| Reference | |
| Functional description | Receptor for endothelin-1. Mediates its action by association with G proteins that activate a phosphatidylinositol-calcium second messenger system. The rank order of binding affinities for ET-A is: ET1 > ET2 >> ET3. |
| Sequence | METFWLRLSF WVALVGGVIS DNPESYSTNL SIHVDSVATF HGTELSFVVT THQPTNLALP 60 SNGSMHNYCP QQTKITSAFK YINTVISCTI FIVGMVGNAT LLRIIYQNKC MRNGPNALIA 120 SLALGDLIYV VIDLPINVFK LLAGRWPFEQ NDFGVFLCKL FPFLQKSSVG ITVLNLCALS 180 VDRYRAVASW SRVQGIGIPL VTAIEIVSIW ILSFILAIPE AIGFVMVPFE YKGAQHRTCM 240 LNATSKFMEF YQDVKDWWLF GFYFCMPLVC TAIFYTLMTC EMLNRRNGSL RIALSEHLKQ 300 RREVAKTVFC LVVIFALCWF PLHLSRILKK TVYDEMDTNR CELLSFLLLM DYIGINLATM 360 NSCINPIALY FVSKKFKNCF QSCLCCCCYQ SKSLMTSVPM NGTSIQWKNH EQNNHNTERS 420 SHKDSIN 427 |
Abbreviation :
CLO : cleft lip only. CPO : cleft palate only.
CLP : cleft lip and palate. CL/P : cleft lip with/without cleft palate.
For humans: CL/P, CLO, CPO, and CLP. For mice: CLO, CLP, and CPO.
| Relation | Gene symbol | Entrez ID | UniProt ID | Cleft type | Developmental stage | Species | Evidence | Details |
|---|---|---|---|---|---|---|---|---|
| 1:1 ortholog | EDNRA | 281749 | P21450 | Bos taurus | Prediction | More>> | ||
| 1:1 ortholog | EDNRA | 450187 | Q5J7U3 | Canis lupus familiaris | Prediction | More>> | ||
| 1:1 ortholog | EDNRA | 102174144 | A0A452FAQ5 | Capra hircus | Prediction | More>> | ||
| 1:1 ortholog | EDNRA | 100062644 | A0A3Q2HSI2 | Equus caballus | Prediction | More>> | ||
| 1:1 ortholog | EDNRA | 1909 | P25101 | Homo sapiens | Prediction | More>> | ||
| 1:1 ortholog | Ednra | 13617 | Q61614 | CPO | Mus musculus | Publication | More>> | |
| 1:1 ortholog | EDNRA | 461530 | H2QQ94 | Pan troglodytes | Prediction | More>> | ||
| 1:1 ortholog | EDNRA | F1RS70 | Sus scrofa | Prediction | More>> | |||
| 1:1 ortholog | ednrA | 100126073 | A5A8K3 | Oryctolagus cuniculus | Prediction | More>> | ||
| 1:1 ortholog | Ednra | 24326 | A0A0G2JSX5 | Rattus norvegicus | Prediction | More>> |
| GO ID | GO Term |
|---|---|
| GO:0016021 | integral component of membrane |
| GO:0005886 | plasma membrane |
| GO:0004962 | endothelin receptor activity |
| GO:0007193 | adenylate cyclase-inhibiting G protein-coupled receptor signaling pathway |
| GO:0014824 | artery smooth muscle contraction |
| GO:0001569 | branching involved in blood vessel morphogenesis |
| GO:0048484 | enteric nervous system development |
| GO:0060322 | head development |
| GO:0007507 | heart development |
| GO:0001701 | in utero embryonic development |
| GO:0014032 | neural crest cell development |
| GO:0008217 | regulation of blood pressure |
| GO:0010827 | regulation of glucose transmembrane transport |
| GO:0007585 | respiratory gaseous exchange by respiratory system |
| GO:0001666 | response to hypoxia |
| Pfam ID | Pfam Term |
|---|---|
| PF00001 | 7tm_1 |