Gene: Ednra

Basic information

Tag Content
Uniprot ID Q61614; O54993; Q91VV2;
Entrez ID 13617
Genbank protein ID AAA16845.1; AAB96671.1; AAH08277.1; BAC31493.1;
Genbank nucleotide ID NM_010332.2
Ensembl protein ID ENSMUSP00000034029
Ensembl nucleotide ID ENSMUSG00000031616
Gene name Endothelin-1 receptor
Gene symbol Ednra
Organism Mus musculus
NCBI taxa ID 10090
Cleft type CPO
Developmental stage
Data sources Manually collected
Reference 19185569
Functional description Receptor for endothelin-1. Mediates its action by association with G proteins that activate a phosphatidylinositol-calcium second messenger system. The rank order of binding affinities for ET-A is: ET1 > ET2 >> ET3 (By similarity).
Sequence
MSIFCLAAYF WLTMVGGVMA DNPERYSANL SSHMEDFTPF PGTEINFLGT THRPPNLALP 60
SNGSMHGYCP QQTKITTAFK YINTVISCTI FIVGMVGNAT LLRIIYQNKC MRNGPNALIA 120
SLALGDLIYV VIDLPINVFK LLAGRWPFDH NDFGVFLCKL FPFLQKSSVG ITVLNLCALS 180
VDRYRAVASW SRVQGIGIPL ITAIEIVSIW ILSFILAIPE AIGFVMVPFE YKGELHRTCM 240
LNATSKFMEF YQDVKDWWLF GFYFCMPLVC TAIFYTLMTC EMLNRRNGSL RIALSEHLKQ 300
RREVAKTVFC LVVIFALCWF PLHLSRILKK TVYDEMDKNR CELLSFLLLM DYIGINLATM 360
NSCINPIALY FVSKKFKNCF QSCLCCCCHQ SKSLMTSVPM NGTSIQWKNQ EQNNHNTERS 420
SHKDSMN 427

Abbreviation :
CLO : cleft lip only. CPO : cleft palate only. CLP : cleft lip and palate. CL/P : cleft lip with/without cleft palate.
For humans: CL/P, CLO, CPO, and CLP. For mice: CLO, CLP, and CPO.

Protein structural annotations

3D structure in PDB database

There is no related protein structure for this gene.

Protein disorder information

Orthologous information

Relation Gene symbol Entrez ID UniProt ID Cleft type Developmental stage Species Evidence Details
1:1 orthologEDNRA281749P21450Bos taurusPredictionMore>>
1:1 orthologEDNRA450187Q5J7U3Canis lupus familiarisPredictionMore>>
1:1 orthologEDNRA102174144A0A452FAQ5Capra hircusPredictionMore>>
1:1 orthologEDNRA100062644A0A3Q2HSI2Equus caballusPredictionMore>>
1:1 orthologEDNRA1909P25101Homo sapiensPredictionMore>>
1:1 orthologEdnra13617Q61614CPOMus musculusPublicationMore>>
1:1 orthologEDNRA461530H2QQ94Pan troglodytesPredictionMore>>
1:1 orthologEDNRAF1RS70Sus scrofaPredictionMore>>
1:1 orthologednrA100126073A5A8K3Oryctolagus cuniculusPredictionMore>>
1:1 orthologEdnra24326A0A0G2JSX5Rattus norvegicusPredictionMore>>

Other genetic variants/mutations

loading...

Gene Ontology (GO)/biological pathways

GO:Molecular Function

GO ID GO Term Evidence
GO:0004930 G protein-coupled receptor activityTAS
GO:0004962 endothelin receptor activityISO
GO:0004962 endothelin receptor activityIMP
GO:0005515 protein bindingIPI
GO:0004713 protein tyrosine kinase activityTAS

GO:Biological Process

GO ID GO Term Evidence
GO:0001569 branching involved in blood vessel morphogenesisIGI
GO:0001666 response to hypoxiaIMP
GO:0001701 in utero embryonic developmentIMP
GO:0001821 histamine secretionISO
GO:0001934 positive regulation of protein phosphorylationISO
GO:0003094 glomerular filtrationISO
GO:0007186 G protein-coupled receptor signaling pathwayTAS
GO:0007193 adenylate cyclase-inhibiting G protein-coupled receptor signaling pathwayIGI
GO:0007204 positive regulation of cytosolic calcium ion concentrationISO
GO:0007205 protein kinase C-activating G protein-coupled receptor signaling pathwayISO
GO:0007266 Rho protein signal transductionISO
GO:0007507 heart developmentIGI
GO:0007585 respiratory gaseous exchange by respiratory systemIMP
GO:0008217 regulation of blood pressureIEA
GO:0008284 positive regulation of cell population proliferationISO
GO:0010827 regulation of glucose transmembrane transportIDA
GO:0014032 neural crest cell developmentIMP
GO:0014824 artery smooth muscle contractionISO
GO:0018108 peptidyl-tyrosine phosphorylationIEA
GO:0019233 sensory perception of painISO
GO:0032496 response to lipopolysaccharideISO
GO:0042310 vasoconstrictionISO
GO:0042310 vasoconstrictionIMP
GO:0042482 positive regulation of odontogenesisISO
GO:0043066 negative regulation of apoptotic processISO
GO:0043084 penile erectionISO
GO:0043278 response to morphineISO
GO:0048144 fibroblast proliferationISO
GO:0048484 enteric nervous system developmentIEA
GO:0048659 smooth muscle cell proliferationISO
GO:0050678 regulation of epithelial cell proliferationISO
GO:0050729 positive regulation of inflammatory responseISO
GO:0051281 positive regulation of release of sequestered calcium ion into cytosolISO
GO:0051482 positive regulation of cytosolic calcium ion concentration involved in phospholipase C-activating G protein-coupled signaling pathwayISO
GO:0051928 positive regulation of calcium ion transportISO
GO:0060322 head developmentIMP
GO:0070374 positive regulation of ERK1 and ERK2 cascadeISO
GO:0071260 cellular response to mechanical stimulusISO
GO:0086100 endothelin receptor signaling pathwayIEA
GO:0090023 positive regulation of neutrophil chemotaxisISO
GO:0090184 positive regulation of kidney developmentISO

GO:Cellular Component

GO ID GO Term Evidence
GO:0005623 cellIEA
GO:0016020 membraneISO
GO:0016021 integral component of membraneIEA
GO:0030315 T-tubuleISO
GO:0031965 nuclear membraneISO
GO:0045121 membrane raftISO

Reactome Pathway

Reactome ID Reactome Term Evidence
R-MMU-162582 Signal TransductionIEA
R-MMU-372790 Signaling by GPCRIEA
R-MMU-373076 Class A/1 (Rhodopsin-like receptors)IEA
R-MMU-375276 Peptide ligand-binding receptorsIEA
R-MMU-388396 GPCR downstream signallingIEA
R-MMU-416476 G alpha (q) signalling eventsIEA
R-MMU-500792 GPCR ligand bindingIEA

Functional annotations

Keywords

Keyword ID Keyword Term
KW-1003 Cell membrane
KW-1015 Disulfide bond
KW-0297 G-protein coupled receptor
KW-0325 Glycoprotein
KW-0472 Membrane
KW-0597 Phosphoprotein
KW-0675 Receptor
KW-1185 Reference proteome
KW-0732 Signal
KW-0807 Transducer
KW-0812 Transmembrane
KW-1133 Transmembrane helix

Interpro

InterPro ID InterPro Term
IPR000499 Endthln_rcpt
IPR002175 ETA_rcpt
IPR000276 GPCR_Rhodpsn
IPR017452 GPCR_Rhodpsn_7TM

PROSITE

PROSITE ID PROSITE Term
PS00237 G_PROTEIN_RECEP_F1_1
PS50262 G_PROTEIN_RECEP_F1_2

Pfam

Pfam ID Pfam Term
PF00001 7tm_1

Protein-protein interaction

Protein-miRNA interaction