| Tag | Content |
|---|---|
| Uniprot ID | A0A0G2JVC1 |
| Entrez ID | 314856 |
| Genbank protein ID | |
| Genbank nucleotide ID | XM_006241383.2; XM_006241382.1; |
| Ensembl protein ID | ENSRNOP00000069425 |
| Ensembl nucleotide ID | ENSRNOG00000006304 |
| Gene name | E3 ubiquitin-protein ligase Mdm2 |
| Gene symbol | Mdm2 |
| Organism | Rattus norvegicus |
| NCBI taxa ID | 10116 |
| Cleft type | |
| Developmental stage | |
| Data sources | Homology search |
| Reference | |
| Functional description | |
| Sequence | MCNTNMSVST EGAAGTSQIP ASEQETLVRP KPLLLKLLKS VGAQKDIYTM KEIIFYIGQY 60 IMTKRLYDEK QQHIVYCSND LLGDVFGVPS FSVKEHRKIY AMIYRNLVVV SQQDSGTSPS 120 ESRCQPEGGS DLKDPVQASQ EEKPSSSDVV SRPSTSSRRR AISETEENTD ELPGERQRKR 180 HRALSFDESL GLCVLREICC ERSSSSEATD TPSHQDLDDG VSDHSADCLD QDSVSDQFSV 240 EFEVESLDSE DYSLSDEGHE LSDEDDEVYR VTVYQAGESD ADSFEGDPEI SLADYWKCTS 300 CNEMNPPLPS HCNRCWTLRE NWLPDDKGKD KVEISEKAKL ESSDQAEEGL DVPDGKKVTE 360 DDAKESSAED SEEKVAQMLL SQESDDYSQP STSSSIVYSS QESGKELKED TQDKEESMES 420 SFSLNAIEPC VICQGRPKNG CIVHGKTGHL MSCFTCAKKL KKRNKPCPVC RQPIQMIVLT 480 YFN 483 |
Abbreviation :
CLO : cleft lip only. CPO : cleft palate only.
CLP : cleft lip and palate. CL/P : cleft lip with/without cleft palate.
For humans: CL/P, CLO, CPO, and CLP. For mice: CLO, CLP, and CPO.
| Relation | Gene symbol | Entrez ID | UniProt ID | Cleft type | Developmental stage | Species | Evidence | Details |
|---|---|---|---|---|---|---|---|---|
| 1:1 ortholog | MDM2 | 540378 | F1MYE6 | Bos taurus | Prediction | More>> | ||
| 1:1 ortholog | MDM2 | 102173163 | A0A452FBR9 | Capra hircus | Prediction | More>> | ||
| 1:1 ortholog | MDM2 | 4193 | Q00987 | Homo sapiens | Prediction | More>> | ||
| 1:1 ortholog | Mdm2 | 17246 | P23804 | CPO | Mus musculus | Publication | More>> | |
| 1:1 ortholog | MDM2 | 742141 | A0A2I3TD93 | Pan troglodytes | Prediction | More>> | ||
| 1:1 ortholog | Mdm2 | 314856 | A0A0G2JVC1 | Rattus norvegicus | Prediction | More>> | ||
| 1:1 ortholog | mdm2 | B0R0S9 | Danio rerio | Prediction | More>> |
| GO ID | GO Term |
|---|---|
| GO:0005737 | cytoplasm |
| GO:0005829 | cytosol |
| GO:0016604 | nuclear body |
| GO:0005730 | nucleolus |
| GO:0005654 | nucleoplasm |
| GO:0005634 | nucleus |
| GO:0005886 | plasma membrane |
| GO:0032991 | protein-containing complex |
| GO:0045202 | synapse |
| GO:0008097 | 5S rRNA binding |
| GO:0097718 | disordered domain specific binding |
| GO:0019899 | enzyme binding |
| GO:0042802 | identical protein binding |
| GO:0016874 | ligase activity |
| GO:0061663 | NEDD8 ligase activity |
| GO:0002039 | p53 binding |
| GO:0042975 | peroxisome proliferator activated receptor binding |
| GO:0019904 | protein domain specific binding |
| GO:0047485 | protein N-terminus binding |
| GO:0033612 | receptor serine/threonine kinase binding |
| GO:0043021 | ribonucleoprotein complex binding |
| GO:0097110 | scaffold protein binding |
| GO:0019789 | SUMO transferase activity |
| GO:0043130 | ubiquitin binding |
| GO:0061630 | ubiquitin protein ligase activity |
| GO:0031625 | ubiquitin protein ligase binding |
| GO:0004842 | ubiquitin-protein transferase activity |
| GO:0008270 | zinc ion binding |
| GO:1990000 | amyloid fibril formation |
| GO:0003283 | atrial septum development |
| GO:0003181 | atrioventricular valve morphogenesis |
| GO:0001568 | blood vessel development |
| GO:0001974 | blood vessel remodeling |
| GO:0060411 | cardiac septum morphogenesis |
| GO:0072717 | cellular response to actinomycin D |
| GO:0071312 | cellular response to alkaloid |
| GO:0071236 | cellular response to antibiotic |
| GO:0071391 | cellular response to estrogen stimulus |
| GO:0071480 | cellular response to gamma radiation |
| GO:0071363 | cellular response to growth factor stimulus |
| GO:0070301 | cellular response to hydrogen peroxide |
| GO:0071456 | cellular response to hypoxia |
| GO:0071407 | cellular response to organic cyclic compound |
| GO:0071310 | cellular response to organic substance |
| GO:0071375 | cellular response to peptide hormone stimulus |
| GO:0071494 | cellular response to UV-C |
| GO:0071301 | cellular response to vitamin B1 |
| GO:0006977 | DNA damage response, signal transduction by p53 class mediator resulting in cell cycle arrest |
| GO:0003203 | endocardial cushion morphogenesis |
| GO:0045184 | establishment of protein localization |
| GO:0007507 | heart development |
| GO:0003170 | heart valve development |
| GO:0043066 | negative regulation of apoptotic process |
| GO:0071157 | negative regulation of cell cycle arrest |
| GO:0043154 | negative regulation of cysteine-type endopeptidase activity involved in apoptotic process |
| GO:0043518 | negative regulation of DNA damage response, signal transduction by p53 class mediator |
| GO:0010629 | negative regulation of gene expression |
| GO:1902254 | negative regulation of intrinsic apoptotic signaling pathway by p53 class mediator |
| GO:0010977 | negative regulation of neuron projection development |
| GO:0010955 | negative regulation of protein processing |
| GO:1901797 | negative regulation of signal transduction by p53 class mediator |
| GO:0000122 | negative regulation of transcription by RNA polymerase II |
| GO:0045892 | negative regulation of transcription, DNA-templated |
| GO:0018205 | peptidyl-lysine modification |
| GO:0045787 | positive regulation of cell cycle |
| GO:0010628 | positive regulation of gene expression |
| GO:0045931 | positive regulation of mitotic cell cycle |
| GO:0051149 | positive regulation of muscle cell differentiation |
| GO:0032436 | positive regulation of proteasomal ubiquitin-dependent protein catabolic process |
| GO:0046827 | positive regulation of protein export from nucleus |
| GO:1904754 | positive regulation of vascular associated smooth muscle cell migration |
| GO:1904707 | positive regulation of vascular smooth muscle cell proliferation |
| GO:0051865 | protein autoubiquitination |
| GO:0031648 | protein destabilization |
| GO:0034504 | protein localization to nucleus |
| GO:0016567 | protein ubiquitination |
| GO:0065003 | protein-containing complex assembly |
| GO:0051603 | proteolysis involved in cellular protein catabolic process |
| GO:0010468 | regulation of gene expression |
| GO:0002027 | regulation of heart rate |
| GO:0042176 | regulation of protein catabolic process |
| GO:0046677 | response to antibiotic |
| GO:0042220 | response to cocaine |
| GO:0042493 | response to drug |
| GO:0045472 | response to ether |
| GO:1904404 | response to formaldehyde |
| GO:0010039 | response to iron ion |
| GO:0032026 | response to magnesium ion |
| GO:0043278 | response to morphine |
| GO:0048545 | response to steroid hormone |
| GO:0009636 | response to toxic substance |
| GO:1990785 | response to water-immersion restraint stress |
| GO:0007089 | traversing start control point of mitotic cell cycle |
| GO:0006511 | ubiquitin-dependent protein catabolic process |
| GO:0003281 | ventricular septum development |