| Tag | Content |
|---|---|
| Uniprot ID | A0A452FBR9 |
| Entrez ID | 102173163 |
| Genbank protein ID | |
| Genbank nucleotide ID | XM_018047968.1; XM_005680196.3; XM_018047969.1; |
| Ensembl protein ID | ENSCHIP00000021696 |
| Ensembl nucleotide ID | ENSCHIG00000019939 |
| Gene name | E3 ubiquitin-protein ligase Mdm2 |
| Gene symbol | MDM2 |
| Organism | Capra hircus |
| NCBI taxa ID | 9925 |
| Cleft type | |
| Developmental stage | |
| Data sources | Homology search |
| Reference | |
| Functional description | |
| Sequence | MCNTNMSVST DGAVSTSQIP ASEQETLVRP KPLLLKLLKS VGAQKDTYTM KEVIFYLGQY 60 IMTKRLYDEK QQHIVYCSND LLGDLFGVPS FSVKEHRKIY TMIYRNLIVV SQQEPSDSGT 120 SVSDNRCHLE GGSNQKDLVQ ELQEEKPSSS DMVSRPSTSS RRRAVSETEE NSDELPGERQ 180 RKRHKSDNIS LSFDESLALC VIREICCERS SSSESTGTPS NPDLDAGVSE HSGDWLDQDS 240 VSDQFSVEFE VESLDSEDYS LSEEGQELSD EDDEVYRVTV YQAGESDTDS FEEDPEISLA 300 DYWKCTSCNE MNPPLPPHCN RCWALRENWL PEDKGKDKGN MSEKAKLGDL MQEDEGFDVP 360 DCKKSTVSDS RESCVEENDD KITQASLSQE SEDYSQPSTS NSIIYSSQED VKEFEREETQ 420 DKEESMESSF PLNAIEPCVI CQGRPKNGCI VHGKTGHLMA CFTCAKKLKK RNKPCPVCRQ 480 PIQMIVLTYF P 491 |
Abbreviation :
CLO : cleft lip only. CPO : cleft palate only.
CLP : cleft lip and palate. CL/P : cleft lip with/without cleft palate.
For humans: CL/P, CLO, CPO, and CLP. For mice: CLO, CLP, and CPO.
| Relation | Gene symbol | Entrez ID | UniProt ID | Cleft type | Developmental stage | Species | Evidence | Details |
|---|---|---|---|---|---|---|---|---|
| 1:1 ortholog | MDM2 | 540378 | F1MYE6 | Bos taurus | Prediction | More>> | ||
| 1:1 ortholog | MDM2 | 102173163 | A0A452FBR9 | Capra hircus | Prediction | More>> | ||
| 1:1 ortholog | MDM2 | 4193 | Q00987 | Homo sapiens | Prediction | More>> | ||
| 1:1 ortholog | Mdm2 | 17246 | P23804 | CPO | Mus musculus | Publication | More>> | |
| 1:1 ortholog | MDM2 | 742141 | A0A2I3TD93 | Pan troglodytes | Prediction | More>> | ||
| 1:1 ortholog | Mdm2 | 314856 | A0A0G2JVC1 | Rattus norvegicus | Prediction | More>> | ||
| 1:1 ortholog | mdm2 | B0R0S9 | Danio rerio | Prediction | More>> |
| GO ID | GO Term |
|---|---|
| GO:0005737 | cytoplasm |
| GO:0016604 | nuclear body |
| GO:0005730 | nucleolus |
| GO:0032991 | protein-containing complex |
| GO:0008097 | 5S rRNA binding |
| GO:0097718 | disordered domain specific binding |
| GO:0042802 | identical protein binding |
| GO:0016874 | ligase activity |
| GO:0061663 | NEDD8 ligase activity |
| GO:0002039 | p53 binding |
| GO:0047485 | protein N-terminus binding |
| GO:0043021 | ribonucleoprotein complex binding |
| GO:0097110 | scaffold protein binding |
| GO:0043130 | ubiquitin binding |
| GO:0061630 | ubiquitin protein ligase activity |
| GO:0031625 | ubiquitin protein ligase binding |
| GO:0008270 | zinc ion binding |
| GO:1990000 | amyloid fibril formation |
| GO:0003283 | atrial septum development |
| GO:0003181 | atrioventricular valve morphogenesis |
| GO:0001568 | blood vessel development |
| GO:0001974 | blood vessel remodeling |
| GO:0060411 | cardiac septum morphogenesis |
| GO:0072717 | cellular response to actinomycin D |
| GO:0071480 | cellular response to gamma radiation |
| GO:0071456 | cellular response to hypoxia |
| GO:0006977 | DNA damage response, signal transduction by p53 class mediator resulting in cell cycle arrest |
| GO:0003203 | endocardial cushion morphogenesis |
| GO:0045184 | establishment of protein localization |
| GO:0071157 | negative regulation of cell cycle arrest |
| GO:0043518 | negative regulation of DNA damage response, signal transduction by p53 class mediator |
| GO:1902254 | negative regulation of intrinsic apoptotic signaling pathway by p53 class mediator |
| GO:0000122 | negative regulation of transcription by RNA polymerase II |
| GO:0018205 | peptidyl-lysine modification |
| GO:0051149 | positive regulation of muscle cell differentiation |
| GO:0032436 | positive regulation of proteasomal ubiquitin-dependent protein catabolic process |
| GO:0051865 | protein autoubiquitination |
| GO:0031648 | protein destabilization |
| GO:0034504 | protein localization to nucleus |
| GO:0065003 | protein-containing complex assembly |
| GO:0002027 | regulation of heart rate |
| GO:0007089 | traversing start control point of mitotic cell cycle |
| GO:0006511 | ubiquitin-dependent protein catabolic process |
| GO:0003281 | ventricular septum development |