| Tag | Content |
|---|---|
| Uniprot ID | F1MYE6 |
| Entrez ID | 540378 |
| Genbank protein ID | |
| Genbank nucleotide ID | XM_005206461.3 |
| Ensembl protein ID | ENSBTAP00000042668; ENSBTAP00000072778; |
| Ensembl nucleotide ID | ENSBTAG00000010422 |
| Gene name | E3 ubiquitin-protein ligase Mdm2 |
| Gene symbol | MDM2 |
| Organism | Bos taurus |
| NCBI taxa ID | 9913 |
| Cleft type | |
| Developmental stage | |
| Data sources | Homology search |
| Reference | |
| Functional description | |
| Sequence | MCNTNMSVST DGAVSTSQIP ASEQETLVRP KPLLLKLLKS VGAQKDTFTM KEVIFYLGQY 60 IMTKRLYDEK QQHIVYCSND LLGDLFGVPS FSVKEHRKIY TMIYRNLVVV SQQAEPSDSG 120 TSVSENRCHL EGGSNQKDLV QELQEEKPSS SDMVSRPSTS SRRRAVSETE ENSDELPGER 180 QRKRHKSDNI SLSFDESLAL CVIREICCER SSSSESTGTP SNPDLDAGVS EHSGDWLDQD 240 SVSDQFSVEF EVESLDSEDY SLSEEGQELS DEDDEVYRVT VYQAGESDTD SFEEDPEISL 300 ADYWKCTSCN EMNPPLPPHC NRCWALRENW LPEDKGKDKG NMSEKAKLGD SMQEDEGFDV 360 PDCKKSTVSD SRESCVEEND DKITQASLSQ ESEDYSQPST SNSIIYSSQE DVKEFEKEET 420 QDKEESMESS FPLNAIEPCV ICQGRPKNGC IVHGKTGHLM ACFTCAKKLK KRNKPCPVCR 480 QPIQMIVLTY FP 492 |
Abbreviation :
CLO : cleft lip only. CPO : cleft palate only.
CLP : cleft lip and palate. CL/P : cleft lip with/without cleft palate.
For humans: CL/P, CLO, CPO, and CLP. For mice: CLO, CLP, and CPO.
| Relation | Gene symbol | Entrez ID | UniProt ID | Cleft type | Developmental stage | Species | Evidence | Details |
|---|---|---|---|---|---|---|---|---|
| 1:1 ortholog | MDM2 | 540378 | F1MYE6 | Bos taurus | Prediction | More>> | ||
| 1:1 ortholog | MDM2 | 102173163 | A0A452FBR9 | Capra hircus | Prediction | More>> | ||
| 1:1 ortholog | MDM2 | 4193 | Q00987 | Homo sapiens | Prediction | More>> | ||
| 1:1 ortholog | Mdm2 | 17246 | P23804 | CPO | Mus musculus | Publication | More>> | |
| 1:1 ortholog | MDM2 | 742141 | A0A2I3TD93 | Pan troglodytes | Prediction | More>> | ||
| 1:1 ortholog | Mdm2 | 314856 | A0A0G2JVC1 | Rattus norvegicus | Prediction | More>> | ||
| 1:1 ortholog | mdm2 | B0R0S9 | Danio rerio | Prediction | More>> |
| GO ID | GO Term |
|---|---|
| GO:0005737 | cytoplasm |
| GO:0016604 | nuclear body |
| GO:0005730 | nucleolus |
| GO:0032991 | protein-containing complex |
| GO:0008097 | 5S rRNA binding |
| GO:0097718 | disordered domain specific binding |
| GO:0042802 | identical protein binding |
| GO:0016874 | ligase activity |
| GO:0061663 | NEDD8 ligase activity |
| GO:0002039 | p53 binding |
| GO:0047485 | protein N-terminus binding |
| GO:0043021 | ribonucleoprotein complex binding |
| GO:0097110 | scaffold protein binding |
| GO:0043130 | ubiquitin binding |
| GO:0061630 | ubiquitin protein ligase activity |
| GO:0031625 | ubiquitin protein ligase binding |
| GO:0008270 | zinc ion binding |
| GO:1990000 | amyloid fibril formation |
| GO:0003283 | atrial septum development |
| GO:0003181 | atrioventricular valve morphogenesis |
| GO:0001568 | blood vessel development |
| GO:0001974 | blood vessel remodeling |
| GO:0060411 | cardiac septum morphogenesis |
| GO:0072717 | cellular response to actinomycin D |
| GO:0071480 | cellular response to gamma radiation |
| GO:0071456 | cellular response to hypoxia |
| GO:0006977 | DNA damage response, signal transduction by p53 class mediator resulting in cell cycle arrest |
| GO:0003203 | endocardial cushion morphogenesis |
| GO:0045184 | establishment of protein localization |
| GO:0071157 | negative regulation of cell cycle arrest |
| GO:0043518 | negative regulation of DNA damage response, signal transduction by p53 class mediator |
| GO:1902254 | negative regulation of intrinsic apoptotic signaling pathway by p53 class mediator |
| GO:0000122 | negative regulation of transcription by RNA polymerase II |
| GO:0018205 | peptidyl-lysine modification |
| GO:0051149 | positive regulation of muscle cell differentiation |
| GO:0032436 | positive regulation of proteasomal ubiquitin-dependent protein catabolic process |
| GO:0051865 | protein autoubiquitination |
| GO:0031648 | protein destabilization |
| GO:0034504 | protein localization to nucleus |
| GO:0065003 | protein-containing complex assembly |
| GO:0002027 | regulation of heart rate |
| GO:0007089 | traversing start control point of mitotic cell cycle |
| GO:0006511 | ubiquitin-dependent protein catabolic process |
| GO:0003281 | ventricular septum development |