Gene: MDM2

Basic information

Tag Content
Uniprot ID F1MYE6
Entrez ID 540378
Genbank protein ID
Genbank nucleotide ID XM_005206461.3
Ensembl protein ID ENSBTAP00000042668; ENSBTAP00000072778;
Ensembl nucleotide ID ENSBTAG00000010422
Gene name E3 ubiquitin-protein ligase Mdm2
Gene symbol MDM2
Organism Bos taurus
NCBI taxa ID 9913
Cleft type
Developmental stage
Data sources Homology search
Reference
Functional description
Sequence
MCNTNMSVST DGAVSTSQIP ASEQETLVRP KPLLLKLLKS VGAQKDTFTM KEVIFYLGQY 60
IMTKRLYDEK QQHIVYCSND LLGDLFGVPS FSVKEHRKIY TMIYRNLVVV SQQAEPSDSG 120
TSVSENRCHL EGGSNQKDLV QELQEEKPSS SDMVSRPSTS SRRRAVSETE ENSDELPGER 180
QRKRHKSDNI SLSFDESLAL CVIREICCER SSSSESTGTP SNPDLDAGVS EHSGDWLDQD 240
SVSDQFSVEF EVESLDSEDY SLSEEGQELS DEDDEVYRVT VYQAGESDTD SFEEDPEISL 300
ADYWKCTSCN EMNPPLPPHC NRCWALRENW LPEDKGKDKG NMSEKAKLGD SMQEDEGFDV 360
PDCKKSTVSD SRESCVEEND DKITQASLSQ ESEDYSQPST SNSIIYSSQE DVKEFEKEET 420
QDKEESMESS FPLNAIEPCV ICQGRPKNGC IVHGKTGHLM ACFTCAKKLK KRNKPCPVCR 480
QPIQMIVLTY FP 492

Abbreviation :
CLO : cleft lip only. CPO : cleft palate only. CLP : cleft lip and palate. CL/P : cleft lip with/without cleft palate.
For humans: CL/P, CLO, CPO, and CLP. For mice: CLO, CLP, and CPO.

Protein disorder information

Orthologous information

Relation Gene symbol Entrez ID UniProt ID Cleft type Developmental stage Species Evidence Details
1:1 orthologMDM2540378F1MYE6Bos taurusPredictionMore>>
1:1 orthologMDM2102173163A0A452FBR9Capra hircusPredictionMore>>
1:1 orthologMDM24193Q00987Homo sapiensPredictionMore>>
1:1 orthologMdm217246P23804CPOMus musculusPublicationMore>>
1:1 orthologMDM2742141A0A2I3TD93Pan troglodytesPredictionMore>>
1:1 orthologMdm2314856A0A0G2JVC1Rattus norvegicusPredictionMore>>
1:1 orthologmdm2B0R0S9Danio rerioPredictionMore>>

Gene ontology

GO ID GO Term
GO:0005737 cytoplasm
GO:0016604 nuclear body
GO:0005730 nucleolus
GO:0032991 protein-containing complex
GO:0008097 5S rRNA binding
GO:0097718 disordered domain specific binding
GO:0042802 identical protein binding
GO:0016874 ligase activity
GO:0061663 NEDD8 ligase activity
GO:0002039 p53 binding
GO:0047485 protein N-terminus binding
GO:0043021 ribonucleoprotein complex binding
GO:0097110 scaffold protein binding
GO:0043130 ubiquitin binding
GO:0061630 ubiquitin protein ligase activity
GO:0031625 ubiquitin protein ligase binding
GO:0008270 zinc ion binding
GO:1990000 amyloid fibril formation
GO:0003283 atrial septum development
GO:0003181 atrioventricular valve morphogenesis
GO:0001568 blood vessel development
GO:0001974 blood vessel remodeling
GO:0060411 cardiac septum morphogenesis
GO:0072717 cellular response to actinomycin D
GO:0071480 cellular response to gamma radiation
GO:0071456 cellular response to hypoxia
GO:0006977 DNA damage response, signal transduction by p53 class mediator resulting in cell cycle arrest
GO:0003203 endocardial cushion morphogenesis
GO:0045184 establishment of protein localization
GO:0071157 negative regulation of cell cycle arrest
GO:0043518 negative regulation of DNA damage response, signal transduction by p53 class mediator
GO:1902254 negative regulation of intrinsic apoptotic signaling pathway by p53 class mediator
GO:0000122 negative regulation of transcription by RNA polymerase II
GO:0018205 peptidyl-lysine modification
GO:0051149 positive regulation of muscle cell differentiation
GO:0032436 positive regulation of proteasomal ubiquitin-dependent protein catabolic process
GO:0051865 protein autoubiquitination
GO:0031648 protein destabilization
GO:0034504 protein localization to nucleus
GO:0065003 protein-containing complex assembly
GO:0002027 regulation of heart rate
GO:0007089 traversing start control point of mitotic cell cycle
GO:0006511 ubiquitin-dependent protein catabolic process
GO:0003281 ventricular septum development

Functional annotations

Keywords

Keyword ID Keyword Term
KW-0963 Cytoplasm
KW-0479 Metal-binding
KW-0539 Nucleus
KW-1185 Reference proteome
KW-0808 Transferase
KW-0833 Ubl conjugation pathway
KW-0862 Zinc
KW-0863 Zinc-finger

Interpro

InterPro ID InterPro Term
IPR028340 Mdm2
IPR015459 MDM2_E3_ligase
IPR016495 p53_neg-reg_MDM_2/4
IPR036885 SWIB_MDM2_dom_sf
IPR003121 SWIB_MDM2_domain
IPR001876 Znf_RanBP2
IPR036443 Znf_RanBP2_sf
IPR001841 Znf_RING
IPR013083 Znf_RING/FYVE/PHD

PROSITE

PROSITE ID PROSITE Term
PS01358 ZF_RANBP2_1
PS50199 ZF_RANBP2_2
PS50089 ZF_RING_2

Pfam

Pfam ID Pfam Term
PF02201 SWIB
PF00641 zf-RanBP