| Tag | Content |
|---|---|
| Uniprot ID | A0A0G2JY48 |
| Entrez ID | |
| Genbank protein ID | |
| Genbank nucleotide ID | |
| Ensembl protein ID | ENSRNOP00000070517 |
| Ensembl nucleotide ID | ENSRNOG00000012531 |
| Gene name | Eph receptor B2 |
| Gene symbol | Ephb2 |
| Organism | Rattus norvegicus |
| NCBI taxa ID | 10116 |
| Cleft type | |
| Developmental stage | |
| Data sources | Homology search |
| Reference | |
| Functional description | |
| Sequence | MAVRRLGAAL LLLPLLAAVE ETLMDSTTAT AELGWMVHPP SGWEEVSGYD ENMNTIRTYQ 60 VCNVFESSQN NWLRTKFIRR RGAHRIHVEM KFSVRDCSSI PSVPGSCKET FNLYYYEADF 120 DLATKTFPNW MENPWVKVDT IAADESFSQV DLGGRVMKIN TEVRSFGPVS RNGFYLAFQD 180 YGGCMSLIAV RVFYRKCPRV IQNGAIFQET LSGAESTSLV AARGSCIANA EEVDVPIKLY 240 CNGDGEWLVP IGRCMCKAGF EAVENGTVCR GCPSGTFKAN QGDEACTHCP INSRTTSEGA 300 TNCVCRNGYY RADLDPLDMP CTTIPSAPQA VISSVNETSL MLEWTPPRDS GGREDLVYNI 360 ICKSCGSGRG ACTRCGDNVQ YAPRQLGLTE PRIYISDLLA HTQYTFEIQA VNGVTDQSPF 420 SPQFASVNIT TNQAAPSAVS IMHQVSRTVD SITLSWSQPD QPNGVILDYE LQYYEKELSE 480 YNATAIKSPT NTVTVQGLKA GAIYVFQVRA RTVAGYGRYS GKMYFQTMTE AEYQTSIKEK 540 LPLIVGSSAA GVVFVIAVVV IAIVCNRRGF ERADSEYTDK LQHYTSGHMT PGMKIYIDPF 600 TYEDPNEAVR EFAKEIDISC VKIEQVIGAG EFGEVCSGHL KLPGKREIFV AIKTLKSGYT 660 EKQRRDFLSE ASIMGQFDHP NVIHLEGVVT KSTPVMIITE FMENGSLDSF LRQNDGQFTV 720 IQLVGMLRGI AAGMKYLADM NYVHRDLAAR NILVNSNLVC KVSDFGLSRF LEDDTSDPTY 780 TSALGGKIPI RWTAPEAIQY RKFTSASDVW SYGIVMWEVM SYGERPYWDM TNQDVINAIE 840 QDYRLPPPMD CPSALHQLML DCWQKDRNHR PKFGQIVNTL DKMIRNPNSL KAMAPLSSGI 900 NLPLLDRTIP DYTSFNTVDE WLEAIKMGQY KESFTNAGFT SFDVVSQMMM EDILRVGVTL 960 AGHQKKILNS IQVMRAQMNQ IQSVEV 986 |
Abbreviation :
CLO : cleft lip only. CPO : cleft palate only.
CLP : cleft lip and palate. CL/P : cleft lip with/without cleft palate.
For humans: CL/P, CLO, CPO, and CLP. For mice: CLO, CLP, and CPO.
| Relation | Gene symbol | Entrez ID | UniProt ID | Cleft type | Developmental stage | Species | Evidence | Details |
|---|---|---|---|---|---|---|---|---|
| 1:1 ortholog | EPHB2 | 102186352 | A0A452FQI3 | Capra hircus | Prediction | More>> | ||
| 1:1 ortholog | EPHB2 | 2048 | P29323 | Homo sapiens | Prediction | More>> | ||
| 1:1 ortholog | Ephb2 | 13844 | P54763 | CPO | E12.5, E13.5, E14.5 | Mus musculus | Publication | More>> |
| 1:1 ortholog | EPHB2 | 456613 | K7CN32 | Pan troglodytes | Prediction | More>> | ||
| 1:1 ortholog | EPHB2 | I3L7R2 | Sus scrofa | Prediction | More>> | |||
| 1:1 ortholog | Ephb2 | A0A0G2JY48 | Rattus norvegicus | Prediction | More>> | |||
| 1:1 ortholog | ephb2b | 554232 | A2CEJ3 | Danio rerio | Prediction | More>> |
| GO ID | GO Term |
|---|---|
| GO:0030424 | axon |
| GO:0030425 | dendrite |
| GO:0098978 | glutamatergic synapse |
| GO:0005887 | integral component of plasma membrane |
| GO:0099055 | integral component of postsynaptic membrane |
| GO:0099056 | integral component of presynaptic membrane |
| GO:0043025 | neuronal cell body |
| GO:0005654 | nucleoplasm |
| GO:0043235 | receptor complex |
| GO:0001540 | amyloid-beta binding |
| GO:0005524 | ATP binding |
| GO:0008046 | axon guidance receptor activity |
| GO:0005003 | ephrin receptor activity |
| GO:0042802 | identical protein binding |
| GO:0004713 | protein tyrosine kinase activity |
| GO:0044877 | protein-containing complex binding |
| GO:0038023 | signaling receptor activity |
| GO:0005102 | signaling receptor binding |
| GO:0004714 | transmembrane receptor protein tyrosine kinase activity |
| GO:0005005 | transmembrane-ephrin receptor activity |
| GO:0001525 | angiogenesis |
| GO:0009887 | animal organ morphogenesis |
| GO:0007411 | axon guidance |
| GO:0007413 | axonal fasciculation |
| GO:0048593 | camera-type eye morphogenesis |
| GO:0000902 | cell morphogenesis |
| GO:0021952 | central nervous system projection neuron axonogenesis |
| GO:0071679 | commissural neuron axon guidance |
| GO:0022038 | corpus callosum development |
| GO:0060996 | dendritic spine development |
| GO:0060997 | dendritic spine morphogenesis |
| GO:0048013 | ephrin receptor signaling pathway |
| GO:0051389 | inactivation of MAPKK activity |
| GO:0042472 | inner ear morphogenesis |
| GO:0007612 | learning |
| GO:0007611 | learning or memory |
| GO:0007275 | multicellular organism development |
| GO:0050771 | negative regulation of axonogenesis |
| GO:0070373 | negative regulation of ERK1 and ERK2 cascade |
| GO:1904782 | negative regulation of NMDA glutamate receptor activity |
| GO:0001933 | negative regulation of protein phosphorylation |
| GO:0046580 | negative regulation of Ras protein signal transduction |
| GO:0106028 | neuron projection retraction |
| GO:0021631 | optic nerve morphogenesis |
| GO:0018108 | peptidyl-tyrosine phosphorylation |
| GO:0016310 | phosphorylation |
| GO:0010628 | positive regulation of gene expression |
| GO:0033674 | positive regulation of kinase activity |
| GO:0048170 | positive regulation of long-term neuronal synaptic plasticity |
| GO:1900273 | positive regulation of long-term synaptic potentiation |
| GO:1904783 | positive regulation of NMDA glutamate receptor activity |
| GO:1903078 | positive regulation of protein localization to plasma membrane |
| GO:0051965 | positive regulation of synapse assembly |
| GO:0031915 | positive regulation of synaptic plasticity |
| GO:0097104 | postsynaptic membrane assembly |
| GO:0006468 | protein phosphorylation |
| GO:0050770 | regulation of axonogenesis |
| GO:0030193 | regulation of blood coagulation |
| GO:0050878 | regulation of body fluid levels |
| GO:0048168 | regulation of neuronal synaptic plasticity |
| GO:0051963 | regulation of synapse assembly |
| GO:0031290 | retinal ganglion cell axon guidance |
| GO:0060021 | roof of mouth development |
| GO:0099557 | trans-synaptic signaling by trans-synaptic complex, modulating synaptic transmission |
| GO:0007169 | transmembrane receptor protein tyrosine kinase signaling pathway |
| GO:0001655 | urogenital system development |
| InterPro ID | InterPro Term |
|---|---|
| IPR027936 | Eph_TM |
| IPR034238 | EphB2_rcpt_lig-bd |
| IPR001090 | Ephrin_rcpt_lig-bd_dom |
| IPR003961 | FN3_dom |
| IPR036116 | FN3_sf |
| IPR008979 | Galactose-bd-like_sf |
| IPR009030 | Growth_fac_rcpt_cys_sf |
| IPR013783 | Ig-like_fold |
| IPR011009 | Kinase-like_dom_sf |
| IPR000719 | Prot_kinase_dom |
| IPR017441 | Protein_kinase_ATP_BS |
| IPR001660 | SAM |
| IPR013761 | SAM/pointed_sf |
| IPR001245 | Ser-Thr/Tyr_kinase_cat_dom |
| IPR011641 | Tyr-kin_ephrin_A/B_rcpt-like |
| IPR008266 | Tyr_kinase_AS |
| IPR020635 | Tyr_kinase_cat_dom |
| IPR016257 | Tyr_kinase_ephrin_rcpt |
| IPR001426 | Tyr_kinase_rcpt_V_CS |