| Tag | Content |
|---|---|
| Uniprot ID | K7CN32; A0A2J8K445; |
| Entrez ID | 456613 |
| Genbank protein ID | JAA27728.1; JAA27729.1; |
| Genbank nucleotide ID | XM_016956078.1 |
| Ensembl protein ID | ENSPTRP00000088689 |
| Ensembl nucleotide ID | ENSPTRG00000000320 |
| Gene name | EPH receptor B2 |
| Gene symbol | EPHB2 |
| Organism | Pan troglodytes |
| NCBI taxa ID | 9598 |
| Cleft type | |
| Developmental stage | |
| Data sources | Homology search |
| Reference | |
| Functional description | |
| Sequence | MALRRLGAAL LLLPLLAAVE ETLMDSTTAT AELGWMVHPP SGWEEVSGYD ENMNTIRTYQ 60 VCNVFESSQN NWLRTKFIRR RGAHRIHVEM KFSVRDCSSI PSVPGSCKET FNLYYYEADF 120 DSATKTFPNW MENPWVKVDT IAADESFSQV DLGGRVMKIN TEVRSFGPVS RSGFYLAFQD 180 YGGCMSLIAV RVFYRKCPRI IQNGAIFQET LSGAESTSLV AARGSCIANA EEVDVPIKLY 240 CNGDGEWLVP IGRCMCKAGF EAVENGTVCR GCPSGTFKAN QGDEACTHCP INSRTTSEGA 300 TNCVCRNGYY RADLDPLDMP CTTIPSAPQA VISSVNETSL MLEWTPPRDS GGREDLVYNI 360 ICKSCGSGRG ACTRCGDNVQ YAPRQLGLTE PRIYISDLLA HTQYTFEIQA VNGVTDQSPF 420 SPQFASVNIT TNQAAPSAVS IMHQVSRTVD SITLSWSQPD QPNGVILDYE LQYYEKELSE 480 YNATAIKSPT NTVTVQGLKA GAIYVFQVRA RTVAGYGRYS GKMYFQTMTE AEYQTSIQEK 540 LPLIIGSSAA GLVFLIAVVV IAIVCNRRGF ERADSEYMDK LQHYTSGHMT PGMKIYIDPF 600 TYEDPNEAVR EFAKEIDISC VKIEQVIGAG EFGEVCSGHL KLPGKREIFV AIKTLKSGYT 660 EKQRRDFLSE ASIMGQFDHP NVIHLEGVVT KSTPVMIITE FMENGSLDSF LRQNDGQFTV 720 IQLVGMLRGI AAGMKYLADM NYVHRDLAAR NILVNSNLVC KVSDFGLSRF LEDDTSDPTY 780 TSALGGKIPI RWTAPEAIQY RKFTSASDVW SYGIVMWEVM SYGERPYWDM TNQDVINAIE 840 QDYRLPPPMD CPSALHQLML DCWQKDRNHR PKFGQIVNTL DKMIRNPNSL KAMAPLSSGI 900 NLPLLDRTIP DYTSFNTVDE WLEAIKMGQY KESFANAGFT SFDVVSQMMM EDILRVGVTL 960 AGHQKKILNS IQVMRAQMNQ IQSVEV 986 |
Abbreviation :
CLO : cleft lip only. CPO : cleft palate only.
CLP : cleft lip and palate. CL/P : cleft lip with/without cleft palate.
For humans: CL/P, CLO, CPO, and CLP. For mice: CLO, CLP, and CPO.
| Relation | Gene symbol | Entrez ID | UniProt ID | Cleft type | Developmental stage | Species | Evidence | Details |
|---|---|---|---|---|---|---|---|---|
| 1:1 ortholog | EPHB2 | 102186352 | A0A452FQI3 | Capra hircus | Prediction | More>> | ||
| 1:1 ortholog | EPHB2 | 2048 | P29323 | Homo sapiens | Prediction | More>> | ||
| 1:1 ortholog | Ephb2 | 13844 | P54763 | CPO | E12.5, E13.5, E14.5 | Mus musculus | Publication | More>> |
| 1:1 ortholog | EPHB2 | 456613 | K7CN32 | Pan troglodytes | Prediction | More>> | ||
| 1:1 ortholog | EPHB2 | I3L7R2 | Sus scrofa | Prediction | More>> | |||
| 1:1 ortholog | Ephb2 | A0A0G2JY48 | Rattus norvegicus | Prediction | More>> | |||
| 1:1 ortholog | ephb2b | 554232 | A2CEJ3 | Danio rerio | Prediction | More>> |
| GO ID | GO Term |
|---|---|
| GO:0005887 | integral component of plasma membrane |
| GO:0005524 | ATP binding |
| GO:0005003 | ephrin receptor activity |
| InterPro ID | InterPro Term |
|---|---|
| IPR027936 | Eph_TM |
| IPR034238 | EphB2_rcpt_lig-bd |
| IPR001090 | Ephrin_rcpt_lig-bd_dom |
| IPR003961 | FN3_dom |
| IPR036116 | FN3_sf |
| IPR008979 | Galactose-bd-like_sf |
| IPR009030 | Growth_fac_rcpt_cys_sf |
| IPR013783 | Ig-like_fold |
| IPR011009 | Kinase-like_dom_sf |
| IPR000719 | Prot_kinase_dom |
| IPR017441 | Protein_kinase_ATP_BS |
| IPR001660 | SAM |
| IPR013761 | SAM/pointed_sf |
| IPR001245 | Ser-Thr/Tyr_kinase_cat_dom |
| IPR011641 | Tyr-kin_ephrin_A/B_rcpt-like |
| IPR008266 | Tyr_kinase_AS |
| IPR020635 | Tyr_kinase_cat_dom |
| IPR016257 | Tyr_kinase_ephrin_rcpt |
| IPR001426 | Tyr_kinase_rcpt_V_CS |