| Tag | Content |
|---|---|
| Uniprot ID | P54763; A3KG00; A3KG01; A3KG02; A3KG89; A3KG90; Q62213; Q6GTQ7; Q6P5F1; Q9QVY4; |
| Entrez ID | 13844 |
| Genbank protein ID | AAH62924.1; CAA53598.1; AAA72411.1; AAH43088.2; |
| Genbank nucleotide ID | NM_001290753.2; NM_010142.4; XM_006538531.3; |
| Ensembl protein ID | ENSMUSP00000101472; ENSMUSP00000058135; ENSMUSP00000101471; |
| Ensembl nucleotide ID | ENSMUSG00000028664 |
| Gene name | Ephrin type-B receptor 2 |
| Gene symbol | Ephb2 |
| Organism | Mus musculus |
| NCBI taxa ID | 10090 |
| Cleft type | CPO |
| Developmental stage | E12.5, E13.5, E14.5 |
| Data sources | Manually collected |
| Reference | 8947026 |
| Functional description | Receptor tyrosine kinase which binds promiscuously transmembrane ephrin-B family ligands residing on adjacent cells, leading to contact-dependent bidirectional signaling into neighboring cells. The signaling pathway downstream of the receptor is referred to as forward signaling while the signaling pathway downstream of the ephrin ligand is referred to as reverse signaling. Functions in axon guidance during development. Involved in the guidance of commissural axons, that form a major interhemispheric connection between the 2 temporal lobes of the cerebral cortex. Also involved in guidance of contralateral inner ear efferent growth cones at the midline and of retinal ganglion cell axons to the optic disk. In addition to axon guidance, also regulates dendritic spines development and maturation and stimulates the formation of excitatory synapses. Upon activation by EFNB1, abolishes the ARHGEF15-mediated negative regulation on excitatory synapse formation. Controls other aspects of development including angiogenesis, palate development and in inner ear development through regulation of endolymph production. Forward and reverse signaling through the EFNB2/EPHB2 complex regulate movement and adhesion of cells that tubularize the urethra and septate the cloaca. May function as a tumor suppressor. May be involved in the regulation of platelet activation and blood coagulation (By similarity). |
| Sequence | MAVRRLGAAL LLLPLLAAVE ETLMDSTTAT AELGWMVHPP SGWEEVSGYD ENMNTIRTYQ 60 VCNVFESSQN NWLRTKFIRR RGAHRIHVEM KFSVRDCSSI PSVPGSCKET FNLYYYEADF 120 DLATKTFPNW MENPWVKVDT IAADESFSQV DLGGRVMKIN TEVRSFGPVS RNGFYLAFQD 180 YGGCMSLIAV RVFYRKCPRI IQNGAIFQET LSGAESTSLV AARGSCIANA EEVDVPIKLY 240 CNGDGEWLVP IGRCMCKAGF EAVENGTVCR GCPSGTFKAN QGDEACTHCP INSRTTSEGA 300 TNCVCRNGYY RADLDPLDMP CTTIPSAPQA VISSVNETSL MLEWTPPRDS GGREDLVYNI 360 ICKSCGSGRG ACTRCGDNVQ YAPRQLGLTE PRIYISDLLA HTQYTFEIQA VNGVTDQSPF 420 SPQFASVNIT TNQAAPSAVS IMHQVSRTVD SITLSWSQPD QPNGVILDYE LQYYEKELSE 480 YNATAIKSPT NTVTVQGLKA GAIYVFQVRA RTVAGYGRYS GKMYFQTMTE AEYQTSIKEK 540 LPLIVGSSAA GLVFLIAVVV IAIVCNRRGF ERADSEYTDK LQHYTSGHMT PGMKIYIDPF 600 TYEDPNEAVR EFAKEIDISC VKIEQVIGAG EFGEVCSGHL KLPGKREIFV AIKTLKSGYT 660 EKQRRDFLSE ASIMGQFDHP NVIHLEGVVT KSTPVMIITE FMENGSLDSF LRQNDGQFTV 720 IQLVGMLRGI AAGMKYLADM NYVHRDLAAR NILVNSNLVC KVSDFGLSRF LEDDTSDPTY 780 TSALGGKIPI RWTAPEAIQY RKFTSASDVW SYGIVMWEVM SYGERPYWDM TNQDVINAIE 840 QDYRLPPPMD CPSALHQLML DCWQKDRNHR PKFGQIVNTL DKMIRNPNSL KAMAPLSSGI 900 NLPLLDRTIP DYTSFNTVDE WLEAIKMGQY KESFANAGFT SFDVVSQMMM EDILRVGVTL 960 AGHQKKILNS IQVMRAQMNQ IQSVEV 986 |
Abbreviation :
CLO : cleft lip only. CPO : cleft palate only.
CLP : cleft lip and palate. CL/P : cleft lip with/without cleft palate.
For humans: CL/P, CLO, CPO, and CLP. For mice: CLO, CLP, and CPO.
| Relation | Gene symbol | Entrez ID | UniProt ID | Cleft type | Developmental stage | Species | Evidence | Details |
|---|---|---|---|---|---|---|---|---|
| 1:1 ortholog | EPHB2 | 102186352 | A0A452FQI3 | Capra hircus | Prediction | More>> | ||
| 1:1 ortholog | EPHB2 | 2048 | P29323 | Homo sapiens | Prediction | More>> | ||
| 1:1 ortholog | Ephb2 | 13844 | P54763 | CPO | E12.5, E13.5, E14.5 | Mus musculus | Publication | More>> |
| 1:1 ortholog | EPHB2 | 456613 | K7CN32 | Pan troglodytes | Prediction | More>> | ||
| 1:1 ortholog | EPHB2 | I3L7R2 | Sus scrofa | Prediction | More>> | |||
| 1:1 ortholog | Ephb2 | A0A0G2JY48 | Rattus norvegicus | Prediction | More>> | |||
| 1:1 ortholog | ephb2b | 554232 | A2CEJ3 | Danio rerio | Prediction | More>> |
| GO ID | GO Term | Evidence |
|---|---|---|
| GO:0001540 | amyloid-beta binding | IPI |
| GO:0004713 | protein tyrosine kinase activity | IMP |
| GO:0004713 | protein tyrosine kinase activity | IDA |
| GO:0004714 | transmembrane receptor protein tyrosine kinase activity | IBA |
| GO:0005003 | ephrin receptor activity | IDA |
| GO:0005005 | transmembrane-ephrin receptor activity | TAS |
| GO:0005005 | transmembrane-ephrin receptor activity | IDA |
| GO:0005102 | signaling receptor binding | IPI |
| GO:0005515 | protein binding | IPI |
| GO:0005524 | ATP binding | IEA |
| GO:0008046 | axon guidance receptor activity | IDA |
| GO:0038023 | signaling receptor activity | IDA |
| GO:0042802 | identical protein binding | IPI |
| GO:0044877 | protein-containing complex binding | ISO |
| GO:0044877 | protein-containing complex binding | IPI |
| GO ID | GO Term | Evidence |
|---|---|---|
| GO:0000902 | cell morphogenesis | IGI |
| GO:0001525 | angiogenesis | IMP |
| GO:0001655 | urogenital system development | IMP |
| GO:0001933 | negative regulation of protein phosphorylation | IDA |
| GO:0006468 | protein phosphorylation | IDA |
| GO:0007169 | transmembrane receptor protein tyrosine kinase signaling pathway | IDA |
| GO:0007169 | transmembrane receptor protein tyrosine kinase signaling pathway | IBA |
| GO:0007275 | multicellular organism development | IBA |
| GO:0007411 | axon guidance | IMP |
| GO:0007411 | axon guidance | IDA |
| GO:0007413 | axonal fasciculation | IMP |
| GO:0007611 | learning or memory | IGI |
| GO:0007612 | learning | IMP |
| GO:0009887 | animal organ morphogenesis | IMP |
| GO:0010628 | positive regulation of gene expression | ISO |
| GO:0016310 | phosphorylation | IDA |
| GO:0018108 | peptidyl-tyrosine phosphorylation | IDA |
| GO:0018108 | peptidyl-tyrosine phosphorylation | IMP |
| GO:0021631 | optic nerve morphogenesis | IMP |
| GO:0021952 | central nervous system projection neuron axonogenesis | IMP |
| GO:0021952 | central nervous system projection neuron axonogenesis | IBA |
| GO:0022038 | corpus callosum development | IMP |
| GO:0030193 | regulation of blood coagulation | ISS |
| GO:0030193 | regulation of blood coagulation | ISO |
| GO:0031290 | retinal ganglion cell axon guidance | IDA |
| GO:0031915 | positive regulation of synaptic plasticity | IGI |
| GO:0033674 | positive regulation of kinase activity | IBA |
| GO:0042472 | inner ear morphogenesis | IMP |
| GO:0046580 | negative regulation of Ras protein signal transduction | IDA |
| GO:0048013 | ephrin receptor signaling pathway | IDA |
| GO:0048168 | regulation of neuronal synaptic plasticity | IMP |
| GO:0048170 | positive regulation of long-term neuronal synaptic plasticity | IMP |
| GO:0048593 | camera-type eye morphogenesis | IMP |
| GO:0050770 | regulation of axonogenesis | IDA |
| GO:0050771 | negative regulation of axonogenesis | IDA |
| GO:0050878 | regulation of body fluid levels | IMP |
| GO:0051389 | inactivation of MAPKK activity | IDA |
| GO:0051963 | regulation of synapse assembly | EXP |
| GO:0051963 | regulation of synapse assembly | IDA |
| GO:0051963 | regulation of synapse assembly | IMP |
| GO:0051965 | positive regulation of synapse assembly | IMP |
| GO:0051965 | positive regulation of synapse assembly | IDA |
| GO:0060021 | roof of mouth development | IMP |
| GO:0060996 | dendritic spine development | IMP |
| GO:0060997 | dendritic spine morphogenesis | IMP |
| GO:0060997 | dendritic spine morphogenesis | IDA |
| GO:0070373 | negative regulation of ERK1 and ERK2 cascade | IDA |
| GO:0071679 | commissural neuron axon guidance | IMP |
| GO:0097104 | postsynaptic membrane assembly | ISO |
| GO:0099557 | trans-synaptic signaling by trans-synaptic complex, modulating synaptic transmission | IMP |
| GO:0106028 | neuron projection retraction | IDA |
| GO:1900273 | positive regulation of long-term synaptic potentiation | IMP |
| GO:1903078 | positive regulation of protein localization to plasma membrane | ISO |
| GO:1904782 | negative regulation of NMDA glutamate receptor activity | IMP |
| GO:1904783 | positive regulation of NMDA glutamate receptor activity | IMP |
| GO ID | GO Term | Evidence |
|---|---|---|
| GO:0005654 | nucleoplasm | ISO |
| GO:0005886 | plasma membrane | ISO |
| GO:0005886 | plasma membrane | TAS |
| GO:0005887 | integral component of plasma membrane | TAS |
| GO:0005887 | integral component of plasma membrane | IBA |
| GO:0005887 | integral component of plasma membrane | IDA |
| GO:0030424 | axon | IDA |
| GO:0030425 | dendrite | IDA |
| GO:0043025 | neuronal cell body | IDA |
| GO:0043235 | receptor complex | IBA |
| GO:0045202 | synapse | NAS |
| GO:0098978 | glutamatergic synapse | ISO |
| GO:0098978 | glutamatergic synapse | EXP |
| GO:0098978 | glutamatergic synapse | IDA |
| GO:0098978 | glutamatergic synapse | IMP |
| GO:0099055 | integral component of postsynaptic membrane | IDA |
| GO:0099056 | integral component of presynaptic membrane | IDA |
| Reactome ID | Reactome Term | Evidence |
|---|---|---|
| R-MMU-1266738 | Developmental Biology | IEA |
| R-MMU-2682334 | EPH-Ephrin signaling | IEA |
| R-MMU-3928662 | EPHB-mediated forward signaling | IEA |
| R-MMU-3928664 | Ephrin signaling | IEA |
| R-MMU-3928665 | EPH-ephrin mediated repulsion of cells | IEA |
| R-MMU-422475 | Axon guidance | IEA |
| Keyword ID | Keyword Term |
|---|---|
| KW-0002 | 3D-structure |
| KW-0025 | Alternative splicing |
| KW-0067 | ATP-binding |
| KW-1003 | Cell membrane |
| KW-0966 | Cell projection |
| KW-0217 | Developmental protein |
| KW-0903 | Direct protein sequencing |
| KW-1015 | Disulfide bond |
| KW-0325 | Glycoprotein |
| KW-0418 | Kinase |
| KW-0472 | Membrane |
| KW-0524 | Neurogenesis |
| KW-0547 | Nucleotide-binding |
| KW-0597 | Phosphoprotein |
| KW-0675 | Receptor |
| KW-1185 | Reference proteome |
| KW-0677 | Repeat |
| KW-0732 | Signal |
| KW-0808 | Transferase |
| KW-0812 | Transmembrane |
| KW-1133 | Transmembrane helix |
| KW-0829 | Tyrosine-protein kinase |
| KW-0832 | Ubl conjugation |
| InterPro ID | InterPro Term |
|---|---|
| IPR027936 | Eph_TM |
| IPR034238 | EphB2_rcpt_lig-bd |
| IPR001090 | Ephrin_rcpt_lig-bd_dom |
| IPR003961 | FN3_dom |
| IPR036116 | FN3_sf |
| IPR008979 | Galactose-bd-like_sf |
| IPR009030 | Growth_fac_rcpt_cys_sf |
| IPR013783 | Ig-like_fold |
| IPR011009 | Kinase-like_dom_sf |
| IPR000719 | Prot_kinase_dom |
| IPR017441 | Protein_kinase_ATP_BS |
| IPR001660 | SAM |
| IPR013761 | SAM/pointed_sf |
| IPR001245 | Ser-Thr/Tyr_kinase_cat_dom |
| IPR011641 | Tyr-kin_ephrin_A/B_rcpt-like |
| IPR008266 | Tyr_kinase_AS |
| IPR020635 | Tyr_kinase_cat_dom |
| IPR016257 | Tyr_kinase_ephrin_rcpt |
| IPR001426 | Tyr_kinase_rcpt_V_CS |