| Tag | Content |
|---|---|
| Uniprot ID | A2CEJ3 |
| Entrez ID | 554232 |
| Genbank protein ID | |
| Genbank nucleotide ID | NM_001327743.1 |
| Ensembl protein ID | ENSDARP00000043755 |
| Ensembl nucleotide ID | ENSDARG00000021539 |
| Gene name | Receptor protein-tyrosine kinase |
| Gene symbol | ephb2b |
| Organism | Danio rerio |
| NCBI taxa ID | 7955 |
| Cleft type | |
| Developmental stage | |
| Data sources | Homology search |
| Reference | |
| Functional description | |
| Sequence | MMDILWILWT LPSVLAIEEI LMDSTTATAE LGWTVYPVSG TSDSSWEEVS GYDENMNTIR 60 TYQVCNVFDA NQNNWVRTKY IRRRGAQRIH VEMKFSVRDC SSIPRVPGSC KETFNLYYYE 120 SDSDTATKTF PPWMENPWIK VDTIAADESF SQVDLGGRVM KINTEVRSFG PVSRNGFYLA 180 FQDYGGCMSL IAVRVFYRKC PRTIRNGAIF QETLSGAEST SLVAARGVCI PNAEEVDVPI 240 KLYCNGDGEW MVPIGRCMCK AGHEAVENGT VCRACPSGFF KTAQGDEKCL QCPINSRTTN 300 DGATNCVCRN GYYRTDSDPL EMPCTTVPSA PQNVISSVNE TSLMLEWNPP RETGGRDDVV 360 YNIICKSCGG GRGGCTRCGD NVQFIPRQLG LTESRVFISD LLAHTQYTFE IQAVNGVSDQ 420 SPYSPQYTSV NITTNQAAPS TVSIMHQVSR TIDSITLSWS QPDQPNGVIL DYELQYYEKD 480 QTEHNSSMVK SQTNTAVIRG LKPGGIYVFQ VRARTVAGFG RYSGKMYFQT MTEEEYNTSI 540 QEKLPLIIGS AAAGLVFLIA VVVIIIVCNR RGFERADSEY TDKLQHYTSG HMSPGMKIYI 600 DPFTYEDPNE AVREFAKEID ISCVKIEQVI GAGEFGEVCS GNLKLPGKRE MFVAIKTLKS 660 GYTEKQRRDF LSEASIMGQF DHPNVIHLEG VVTKSSPVMI ITEFMENGSL DSFLRQNDGQ 720 FTVIQLVGML RGIASGMKYL ADMNYVHRDL AARNILVNSN LVCKVSDFGL SRFLEDDTSD 780 PTYTSALGGK IPIRWTAPEA IQYRKFTSAS DVWSYGIVMW EVMSYGERPY WDMTNQDVIN 840 AIEQDYRLPP PMDCPSALHQ LMLDCWQKDR NNRPKFSQIV NNLDKMIRNP NSLKAMTPLS 900 SGVHLPLLDR SVPDFSSFSS VDDWLDAIKM GQYKDNFANG NFTSFDLVSQ MTMEDILRVG 960 VTLAGHQKKI LNSVQMMRAQ MNQIQSVEV 989 |
Abbreviation :
CLO : cleft lip only. CPO : cleft palate only.
CLP : cleft lip and palate. CL/P : cleft lip with/without cleft palate.
For humans: CL/P, CLO, CPO, and CLP. For mice: CLO, CLP, and CPO.
| Relation | Gene symbol | Entrez ID | UniProt ID | Cleft type | Developmental stage | Species | Evidence | Details |
|---|---|---|---|---|---|---|---|---|
| 1:1 ortholog | EPHB2 | 102186352 | A0A452FQI3 | Capra hircus | Prediction | More>> | ||
| 1:1 ortholog | EPHB2 | 2048 | P29323 | Homo sapiens | Prediction | More>> | ||
| 1:1 ortholog | Ephb2 | 13844 | P54763 | CPO | E12.5, E13.5, E14.5 | Mus musculus | Publication | More>> |
| 1:1 ortholog | EPHB2 | 456613 | K7CN32 | Pan troglodytes | Prediction | More>> | ||
| 1:1 ortholog | EPHB2 | I3L7R2 | Sus scrofa | Prediction | More>> | |||
| 1:1 ortholog | Ephb2 | A0A0G2JY48 | Rattus norvegicus | Prediction | More>> | |||
| 1:1 ortholog | ephb2b | 554232 | A2CEJ3 | Danio rerio | Prediction | More>> |
| GO ID | GO Term |
|---|---|
| GO:0005887 | integral component of plasma membrane |
| GO:0043005 | neuron projection |
| GO:0043235 | receptor complex |
| GO:0005524 | ATP binding |
| GO:0004714 | transmembrane receptor protein tyrosine kinase activity |
| GO:0005005 | transmembrane-ephrin receptor activity |
| GO:0007411 | axon guidance |
| GO:0021952 | central nervous system projection neuron axonogenesis |
| GO:0007275 | multicellular organism development |
| GO:0033674 | positive regulation of kinase activity |
| GO:0007169 | transmembrane receptor protein tyrosine kinase signaling pathway |
| Keyword ID | Keyword Term |
|---|---|
| KW-0067 | ATP-binding |
| KW-1003 | Cell membrane |
| KW-0325 | Glycoprotein |
| KW-0418 | Kinase |
| KW-0472 | Membrane |
| KW-0547 | Nucleotide-binding |
| KW-0675 | Receptor |
| KW-1185 | Reference proteome |
| KW-0677 | Repeat |
| KW-0732 | Signal |
| KW-0808 | Transferase |
| KW-0812 | Transmembrane |
| KW-1133 | Transmembrane helix |
| KW-0829 | Tyrosine-protein kinase |
| InterPro ID | InterPro Term |
|---|---|
| IPR027936 | Eph_TM |
| IPR034238 | EphB2_rcpt_lig-bd |
| IPR001090 | Ephrin_rcpt_lig-bd_dom |
| IPR003961 | FN3_dom |
| IPR036116 | FN3_sf |
| IPR008979 | Galactose-bd-like_sf |
| IPR009030 | Growth_fac_rcpt_cys_sf |
| IPR013783 | Ig-like_fold |
| IPR011009 | Kinase-like_dom_sf |
| IPR000719 | Prot_kinase_dom |
| IPR017441 | Protein_kinase_ATP_BS |
| IPR001660 | SAM |
| IPR013761 | SAM/pointed_sf |
| IPR001245 | Ser-Thr/Tyr_kinase_cat_dom |
| IPR011641 | Tyr-kin_ephrin_A/B_rcpt-like |
| IPR008266 | Tyr_kinase_AS |
| IPR020635 | Tyr_kinase_cat_dom |
| IPR016257 | Tyr_kinase_ephrin_rcpt |
| IPR001426 | Tyr_kinase_rcpt_V_CS |