Gene: EPHB2

Basic information

Tag Content
Uniprot ID I3L7R2
Entrez ID
Genbank protein ID
Genbank nucleotide ID XM_005656048.2
Ensembl protein ID ENSSSCP00000020068
Ensembl nucleotide ID ENSSSCG00000003527
Gene name EPH receptor B2
Gene symbol EPHB2
Organism Sus scrofa
NCBI taxa ID 9823
Cleft type
Developmental stage
Data sources Homology search
Reference
Functional description
Sequence
MGSQSLWYPF LETLMDSTTA TAELGWIVHP PSGWEEVSGY DENMNTIRTY QVCNVFESSQ 60
NNWLRTKFIR RRGAHRIHVE MKFSVRDCSS IPSVPGSCKE TFNLYYYEAD FDSATKTFPN 120
WMENPWVKVD TIAADESFSQ VDLGGRVMKI NTEVRSFGPV SRSGFYLAFQ DYGGCMSLIA 180
VRVFYRKCPR IIQNGAVFQE TLSGAESTSL VAARGSCIAN AEEVDVPIKL YCNGDGEWLV 240
PIGRCMCKAG FEAVENGTVC RGCPSGTFKA NQGDEACTHC PINSRTTSEG ATNCVCRNGY 300
YRADLDPLDM PCTTIPSAPQ AVISSVNETS LMLEWTPPRD SGGREDLVYN IICKSCGSGR 360
GACTRCGDNV QYAPRQLGLT EPRIYISDLL AHTQYTFEIQ AVNGVTDQSP FSPQFASVNI 420
TTNQAAPSAV SIMHQVSRTV DSITLSWSQP DQPNGVILDY ELQYYEKELS EYNATAIKSP 480
TNTVTVQGLK AGAIYVFQVR ARTVAGYGRY SGKMYFQTMT EAEYQTSIQE KLPLIIGSSA 540
AGLVFLIAVV VIAIVCNRRG FERADSEYTD KLQHYTSGHM TPGMKIYIDP FTYEDPNEAV 600
REFAKEIDIS CVKIEQVIGA GEFGEVCSGH LKLPGKREIF VAIKTLKSGY TEKQRRDFLS 660
EASIMGQFDH PNVIHLEGVV TKSTPVMIIT EFMENGSLDS FLRQNDGQFT VIQLVGMLRG 720
IAAGMKYLAD MNYVHRDLAA RNILVNSNLV CKVSDFGLSR FLEDDTSDPT YTSALGGKIP 780
IRWTAPEAIQ YRKFTSASDV WSYGIVMWEV MSYGERPYWD MTNQDVINAI EQDYRLPPPM 840
DCPSALHQLM LDCWQKDRNH RPKFGQIVNT LDKMIRNPNS LKAMAPLSSG INLPLLDRTI 900
PDYTSFNTVD EWLEAIKMGQ YKESFANAGF TSFDVVSQMM MEDILRVGVT LAGHQKKILN 960
SIQVMRAQMN QIQSVEV 977

Abbreviation :
CLO : cleft lip only. CPO : cleft palate only. CLP : cleft lip and palate. CL/P : cleft lip with/without cleft palate.
For humans: CL/P, CLO, CPO, and CLP. For mice: CLO, CLP, and CPO.

Protein disorder information

Orthologous information

Relation Gene symbol Entrez ID UniProt ID Cleft type Developmental stage Species Evidence Details
1:1 orthologEPHB2102186352A0A452FQI3Capra hircusPredictionMore>>
1:1 orthologEPHB22048P29323Homo sapiensPredictionMore>>
1:1 orthologEphb213844P54763CPOE12.5, E13.5, E14.5Mus musculusPublicationMore>>
1:1 orthologEPHB2456613K7CN32Pan troglodytesPredictionMore>>
1:1 orthologEPHB2I3L7R2Sus scrofaPredictionMore>>
1:1 orthologEphb2A0A0G2JY48Rattus norvegicusPredictionMore>>
1:1 orthologephb2b554232A2CEJ3Danio rerioPredictionMore>>

Gene ontology

GO ID GO Term
GO:0005887 integral component of plasma membrane
GO:0005524 ATP binding
GO:0005003 ephrin receptor activity

Functional annotations

Keywords

Keyword ID Keyword Term
KW-0067 ATP-binding
KW-0418 Kinase
KW-0472 Membrane
KW-0547 Nucleotide-binding
KW-1267 Proteomics identification
KW-0675 Receptor
KW-1185 Reference proteome
KW-0677 Repeat
KW-0808 Transferase
KW-0812 Transmembrane
KW-1133 Transmembrane helix
KW-0829 Tyrosine-protein kinase

Interpro

InterPro ID InterPro Term
IPR027936 Eph_TM
IPR034238 EphB2_rcpt_lig-bd
IPR001090 Ephrin_rcpt_lig-bd_dom
IPR003961 FN3_dom
IPR036116 FN3_sf
IPR008979 Galactose-bd-like_sf
IPR009030 Growth_fac_rcpt_cys_sf
IPR013783 Ig-like_fold
IPR011009 Kinase-like_dom_sf
IPR000719 Prot_kinase_dom
IPR017441 Protein_kinase_ATP_BS
IPR001660 SAM
IPR013761 SAM/pointed_sf
IPR001245 Ser-Thr/Tyr_kinase_cat_dom
IPR011641 Tyr-kin_ephrin_A/B_rcpt-like
IPR008266 Tyr_kinase_AS
IPR020635 Tyr_kinase_cat_dom
IPR016257 Tyr_kinase_ephrin_rcpt
IPR001426 Tyr_kinase_rcpt_V_CS

PROSITE

PROSITE ID PROSITE Term
PS51550 EPH_LBD
PS50853 FN3
PS00107 PROTEIN_KINASE_ATP
PS50011 PROTEIN_KINASE_DOM
PS00109 PROTEIN_KINASE_TYR
PS00790 RECEPTOR_TYR_KIN_V_1
PS00791 RECEPTOR_TYR_KIN_V_2
PS50105 SAM_DOMAIN

Pfam

Pfam ID Pfam Term
PF14575 EphA2_TM
PF01404 Ephrin_lbd
PF07699 Ephrin_rec_like
PF00041 fn3
PF07714 Pkinase_Tyr
PF00536 SAM_1