| Tag | Content |
|---|---|
| Uniprot ID | A0A0G2K2C0 |
| Entrez ID | |
| Genbank protein ID | |
| Genbank nucleotide ID | |
| Ensembl protein ID | ENSRNOP00000072181 |
| Ensembl nucleotide ID | ENSRNOG00000057031 |
| Gene name | SIX homeobox 3 |
| Gene symbol | Six3 |
| Organism | Rattus norvegicus |
| NCBI taxa ID | 10116 |
| Cleft type | |
| Developmental stage | |
| Data sources | Homology search |
| Reference | |
| Functional description | |
| Sequence | MVFGXPLDLY SSHFLLLPSP ILTTAPYFWR VAAGSGAGGG GGAGGGGGGG GGNRAGGGGA 60 GGAGGGGGGG GGGSRAPPEE LSMFQLPTLN FSPEQVASVC ETLEETGDIE RLGRFLWSLP 120 VAPGACEAIN KHESILRARA VVAFHTGNFR DLYHILENHK FTKESHGKLQ AMWLEAHYQE 180 AEKLRGRPLG PVDKYRVRKK FPLPRTIWDG EQKTHCFKER TRSLLREWYL QDPYPNPSKK 240 RELAQATGLT PTQVGNWFKN RRQRDRAAAA KNRLQHQAIG PSGMRSLAEP GCPTHGSAES 300 PSTAASPTTS VSSLTERADT GTSILSVTSS DSECDV 336 |
Abbreviation :
CLO : cleft lip only. CPO : cleft palate only.
CLP : cleft lip and palate. CL/P : cleft lip with/without cleft palate.
For humans: CL/P, CLO, CPO, and CLP. For mice: CLO, CLP, and CPO.
| Relation | Gene symbol | Entrez ID | UniProt ID | Cleft type | Developmental stage | Species | Evidence | Details |
|---|---|---|---|---|---|---|---|---|
| 1:1 ortholog | SIX3 | 616756 | E1BMT1 | Bos taurus | Prediction | More>> | ||
| 1:1 ortholog | SIX3 | 102179678 | A0A452E3R7 | Capra hircus | Prediction | More>> | ||
| 1:1 ortholog | SIX3 | 6496 | O95343 | Homo sapiens | Prediction | More>> | ||
| 1:1 ortholog | Six3 | 20473 | Q62233 | CPO | Mus musculus | Publication | More>> | |
| 1:1 ortholog | SIX3 | 470367 | H2QHU7 | Pan troglodytes | Prediction | More>> | ||
| 1:1 ortholog | Six3 | A0A0G2K2C0 | Rattus norvegicus | Prediction | More>> | |||
| 1:1 ortholog | six3a | Q6PCA5 | Danio rerio | Prediction | More>> |
| GO ID | GO Term |
|---|---|
| GO:0005634 | nucleus |
| GO:0005667 | transcription factor complex |
| GO:0003677 | DNA binding |
| GO:0001228 | DNA-binding transcription activator activity, RNA polymerase II-specific |
| GO:0003700 | DNA-binding transcription factor activity |
| GO:0000981 | DNA-binding transcription factor activity, RNA polymerase II-specific |
| GO:0042826 | histone deacetylase binding |
| GO:0000978 | RNA polymerase II cis-regulatory region sequence-specific DNA binding |
| GO:0043565 | sequence-specific DNA binding |
| GO:0005102 | signaling receptor binding |
| GO:0003713 | transcription coactivator activity |
| GO:0001222 | transcription corepressor binding |
| GO:0000976 | transcription regulatory region sequence-specific DNA binding |
| GO:0048856 | anatomical structure development |
| GO:1902742 | apoptotic process involved in development |
| GO:0007420 | brain development |
| GO:0043010 | camera-type eye development |
| GO:0021846 | cell proliferation in forebrain |
| GO:0048512 | circadian behavior |
| GO:0021536 | diencephalon development |
| GO:0002070 | epithelial cell maturation |
| GO:0001654 | eye development |
| GO:0021797 | forebrain anterior/posterior pattern specification |
| GO:0021798 | forebrain dorsal/ventral pattern formation |
| GO:0002088 | lens development in camera-type eye |
| GO:1990086 | lens fiber cell apoptotic process |
| GO:0070306 | lens fiber cell differentiation |
| GO:0060235 | lens induction in camera-type eye |
| GO:0045665 | negative regulation of neuron differentiation |
| GO:0045892 | negative regulation of transcription, DNA-templated |
| GO:0030178 | negative regulation of Wnt signaling pathway |
| GO:0014016 | neuroblast differentiation |
| GO:0097402 | neuroblast migration |
| GO:0003404 | optic vesicle morphogenesis |
| GO:0021983 | pituitary gland development |
| GO:0045944 | positive regulation of transcription by RNA polymerase II |
| GO:0006606 | protein import into nucleus |
| GO:0009946 | proximal/distal axis specification |
| GO:1901987 | regulation of cell cycle phase transition |
| GO:0042127 | regulation of cell population proliferation |
| GO:2000177 | regulation of neural precursor cell proliferation |
| GO:0061074 | regulation of neural retina development |
| GO:1902692 | regulation of neuroblast proliferation |
| GO:0021537 | telencephalon development |
| GO:0021978 | telencephalon regionalization |
| PROSITE ID | PROSITE Term |
|---|---|
| PS50071 | HOMEOBOX_2 |