| Tag | Content |
|---|---|
| Uniprot ID | E1BMT1 |
| Entrez ID | 616756 |
| Genbank protein ID | |
| Genbank nucleotide ID | NM_001193124.1 |
| Ensembl protein ID | ENSBTAP00000038493 |
| Ensembl nucleotide ID | ENSBTAG00000027017 |
| Gene name | SIX homeobox 3 |
| Gene symbol | SIX3 |
| Organism | Bos taurus |
| NCBI taxa ID | 9913 |
| Cleft type | |
| Developmental stage | |
| Data sources | Homology search |
| Reference | |
| Functional description | |
| Sequence | MVFRSPLDLY SSHFLLPNFA DSHHRSLLLA SSGGGNGSGG GGGGSGGNGV GGGGAGGAGG 60 GGGGGSRAPP EELSMFQLPT LNFSPEQVAS VCETLEETGD IERLGRFLWS LPVAPGACEA 120 INKHESILRA RAVVAFHTGN FRDLYHILEN HKFTKESHGK LQAMWLEAHY QEAEKLRGRP 180 LGPVDKYRVR KKFPLPRTIW DGEQKTHCFK ERTRSLLREW YLQDPYPNPS KKRELAQATG 240 LTPTQVGNWF KNRRQRDRAA AAKNRLQHQA IGPSGMRSLA EPGCPTHGSA ESPSTAASPT 300 TSVSSLTERA DTGTSILSVT SSDSECDV 328 |
Abbreviation :
CLO : cleft lip only. CPO : cleft palate only.
CLP : cleft lip and palate. CL/P : cleft lip with/without cleft palate.
For humans: CL/P, CLO, CPO, and CLP. For mice: CLO, CLP, and CPO.
| Relation | Gene symbol | Entrez ID | UniProt ID | Cleft type | Developmental stage | Species | Evidence | Details |
|---|---|---|---|---|---|---|---|---|
| 1:1 ortholog | SIX3 | 616756 | E1BMT1 | Bos taurus | Prediction | More>> | ||
| 1:1 ortholog | SIX3 | 102179678 | A0A452E3R7 | Capra hircus | Prediction | More>> | ||
| 1:1 ortholog | SIX3 | 6496 | O95343 | Homo sapiens | Prediction | More>> | ||
| 1:1 ortholog | Six3 | 20473 | Q62233 | CPO | Mus musculus | Publication | More>> | |
| 1:1 ortholog | SIX3 | 470367 | H2QHU7 | Pan troglodytes | Prediction | More>> | ||
| 1:1 ortholog | Six3 | A0A0G2K2C0 | Rattus norvegicus | Prediction | More>> | |||
| 1:1 ortholog | six3a | Q6PCA5 | Danio rerio | Prediction | More>> |
| GO ID | GO Term |
|---|---|
| GO:0005634 | nucleus |
| GO:0005667 | transcription factor complex |
| GO:0001228 | DNA-binding transcription activator activity, RNA polymerase II-specific |
| GO:0000981 | DNA-binding transcription factor activity, RNA polymerase II-specific |
| GO:0042826 | histone deacetylase binding |
| GO:0000978 | RNA polymerase II cis-regulatory region sequence-specific DNA binding |
| GO:0003713 | transcription coactivator activity |
| GO:0001222 | transcription corepressor binding |
| GO:0000976 | transcription regulatory region sequence-specific DNA binding |
| GO:0048856 | anatomical structure development |
| GO:1902742 | apoptotic process involved in development |
| GO:0007420 | brain development |
| GO:0021846 | cell proliferation in forebrain |
| GO:0048512 | circadian behavior |
| GO:0002070 | epithelial cell maturation |
| GO:0001654 | eye development |
| GO:0021797 | forebrain anterior/posterior pattern specification |
| GO:0021798 | forebrain dorsal/ventral pattern formation |
| GO:1990086 | lens fiber cell apoptotic process |
| GO:0070306 | lens fiber cell differentiation |
| GO:0060235 | lens induction in camera-type eye |
| GO:0045665 | negative regulation of neuron differentiation |
| GO:0045892 | negative regulation of transcription, DNA-templated |
| GO:0030178 | negative regulation of Wnt signaling pathway |
| GO:0014016 | neuroblast differentiation |
| GO:0097402 | neuroblast migration |
| GO:0003404 | optic vesicle morphogenesis |
| GO:0021983 | pituitary gland development |
| GO:0006606 | protein import into nucleus |
| GO:0009946 | proximal/distal axis specification |
| GO:1901987 | regulation of cell cycle phase transition |
| GO:0061074 | regulation of neural retina development |
| GO:1902692 | regulation of neuroblast proliferation |
| GO:0021978 | telencephalon regionalization |
| PROSITE ID | PROSITE Term |
|---|---|
| PS50071 | HOMEOBOX_2 |