Gene: SIX3

Basic information

Tag Content
Uniprot ID H2QHU7; A0A2J8LL71;
Entrez ID 470367
Genbank protein ID
Genbank nucleotide ID XM_016948454.1
Ensembl protein ID ENSPTRP00000020406
Ensembl nucleotide ID ENSPTRG00000011887
Gene name SIX homeobox 3
Gene symbol SIX3
Organism Pan troglodytes
NCBI taxa ID 9598
Cleft type
Developmental stage
Data sources Homology search
Reference
Functional description
Sequence
MVFRSPLDLY SSHFLLPNFA DSHHRSILLA SSGGGNGAGG GGDAGGGSGG GNGAGGGGAG 60
GAGGGGGGSR APPEELSMFQ LPTLNFSPEQ VASVCETLEE TGDIERLGRF LWSLPVAPGA 120
CEAINKHESI LRARAVVAFH TGNFRDLYHI LENHKFTKES HGKLQAMWLE AHYQEAEKLR 180
GRPLGPVDKY RVRKKFPLPR TIWDGEQKTH CFKERTRSLL REWYLQDPYP NPSKKRELAQ 240
ATGLTPTQVG NWFKNRRQRD RAAAAKNRLQ HQAIGPSGMR SLAEPGCPTH GSAESPSTAA 300
SPTTSVSSLT ERADTGTSIL SVTSSDSECD V 331

Abbreviation :
CLO : cleft lip only. CPO : cleft palate only. CLP : cleft lip and palate. CL/P : cleft lip with/without cleft palate.
For humans: CL/P, CLO, CPO, and CLP. For mice: CLO, CLP, and CPO.

Protein disorder information

Orthologous information

Relation Gene symbol Entrez ID UniProt ID Cleft type Developmental stage Species Evidence Details
1:1 orthologSIX3616756E1BMT1Bos taurusPredictionMore>>
1:1 orthologSIX3102179678A0A452E3R7Capra hircusPredictionMore>>
1:1 orthologSIX36496O95343Homo sapiensPredictionMore>>
1:1 orthologSix320473Q62233CPOMus musculusPublicationMore>>
1:1 orthologSIX3470367H2QHU7Pan troglodytesPredictionMore>>
1:1 orthologSix3A0A0G2K2C0Rattus norvegicusPredictionMore>>
1:1 orthologsix3aQ6PCA5Danio rerioPredictionMore>>

Gene ontology

GO ID GO Term
GO:0005634 nucleus
GO:0005667 transcription factor complex
GO:0001228 DNA-binding transcription activator activity, RNA polymerase II-specific
GO:0000981 DNA-binding transcription factor activity, RNA polymerase II-specific
GO:0042826 histone deacetylase binding
GO:0000978 RNA polymerase II cis-regulatory region sequence-specific DNA binding
GO:0003713 transcription coactivator activity
GO:0001222 transcription corepressor binding
GO:0000976 transcription regulatory region sequence-specific DNA binding
GO:0048856 anatomical structure development
GO:1902742 apoptotic process involved in development
GO:0007420 brain development
GO:0021846 cell proliferation in forebrain
GO:0048512 circadian behavior
GO:0002070 epithelial cell maturation
GO:0001654 eye development
GO:0021797 forebrain anterior/posterior pattern specification
GO:0021798 forebrain dorsal/ventral pattern formation
GO:1990086 lens fiber cell apoptotic process
GO:0070306 lens fiber cell differentiation
GO:0060235 lens induction in camera-type eye
GO:0045665 negative regulation of neuron differentiation
GO:0045892 negative regulation of transcription, DNA-templated
GO:0030178 negative regulation of Wnt signaling pathway
GO:0014016 neuroblast differentiation
GO:0097402 neuroblast migration
GO:0003404 optic vesicle morphogenesis
GO:0021983 pituitary gland development
GO:0006606 protein import into nucleus
GO:0009946 proximal/distal axis specification
GO:1901987 regulation of cell cycle phase transition
GO:0061074 regulation of neural retina development
GO:1902692 regulation of neuroblast proliferation
GO:0021978 telencephalon regionalization

Functional annotations

Keywords

Keyword ID Keyword Term
KW-0238 DNA-binding
KW-0371 Homeobox
KW-0539 Nucleus
KW-1185 Reference proteome

Interpro

InterPro ID InterPro Term
IPR009057 Homeobox-like_sf
IPR001356 Homeobox_dom
IPR031701 SIX1_SD
IPR032949 SIX3

PROSITE

PROSITE ID PROSITE Term
PS50071 HOMEOBOX_2

Pfam

Pfam ID Pfam Term
PF00046 Homeodomain
PF16878 SIX1_SD