| Tag | Content |
|---|---|
| Uniprot ID | A0A452E3R7 |
| Entrez ID | 102179678 |
| Genbank protein ID | |
| Genbank nucleotide ID | XM_018054761.1 |
| Ensembl protein ID | ENSCHIP00000006633 |
| Ensembl nucleotide ID | ENSCHIG00000010414 |
| Gene name | Homeobox domain-containing protein |
| Gene symbol | SIX3 |
| Organism | Capra hircus |
| NCBI taxa ID | 9925 |
| Cleft type | |
| Developmental stage | |
| Data sources | Homology search |
| Reference | |
| Functional description | |
| Sequence | MVFRSPLDLY SSHFLLPNFA DSHHRSLLLA SSGGGNGSGG GGGGGNGVGG GGAGGAGGGG 60 GGSRAPPEEL SMFQLPTLNF SPEQVASVCE TLEETGDIER LGRFLWSLPV APGACEAINK 120 HESILRARAV VAFHTGNFRD LYHILENHKF TKESHGKLQA MWLEAHYQEA EKLRGRPLGP 180 VDKYRVRKKF PLPRTIWDGE QKTHCFKERT RSLLREWYLQ DPYPNPSKKR ELAQATGLTP 240 TQVGNWFKNR RQRDRAAAAK NRLQHQAIGP SGMRSLAEPG CPTHGSAESP STAASPTTSV 300 SSLTERADTG TSILSVTSSD SECDV 325 |
Abbreviation :
CLO : cleft lip only. CPO : cleft palate only.
CLP : cleft lip and palate. CL/P : cleft lip with/without cleft palate.
For humans: CL/P, CLO, CPO, and CLP. For mice: CLO, CLP, and CPO.
| Relation | Gene symbol | Entrez ID | UniProt ID | Cleft type | Developmental stage | Species | Evidence | Details |
|---|---|---|---|---|---|---|---|---|
| 1:1 ortholog | SIX3 | 616756 | E1BMT1 | Bos taurus | Prediction | More>> | ||
| 1:1 ortholog | SIX3 | 102179678 | A0A452E3R7 | Capra hircus | Prediction | More>> | ||
| 1:1 ortholog | SIX3 | 6496 | O95343 | Homo sapiens | Prediction | More>> | ||
| 1:1 ortholog | Six3 | 20473 | Q62233 | CPO | Mus musculus | Publication | More>> | |
| 1:1 ortholog | SIX3 | 470367 | H2QHU7 | Pan troglodytes | Prediction | More>> | ||
| 1:1 ortholog | Six3 | A0A0G2K2C0 | Rattus norvegicus | Prediction | More>> | |||
| 1:1 ortholog | six3a | Q6PCA5 | Danio rerio | Prediction | More>> |
| GO ID | GO Term |
|---|---|
| GO:0005634 | nucleus |
| GO:0001228 | DNA-binding transcription activator activity, RNA polymerase II-specific |
| GO:0042826 | histone deacetylase binding |
| GO:0000978 | RNA polymerase II cis-regulatory region sequence-specific DNA binding |
| GO:0003713 | transcription coactivator activity |
| GO:0001222 | transcription corepressor binding |
| GO:1902742 | apoptotic process involved in development |
| GO:0021846 | cell proliferation in forebrain |
| GO:0048512 | circadian behavior |
| GO:0002070 | epithelial cell maturation |
| GO:0021797 | forebrain anterior/posterior pattern specification |
| GO:0021798 | forebrain dorsal/ventral pattern formation |
| GO:1990086 | lens fiber cell apoptotic process |
| GO:0070306 | lens fiber cell differentiation |
| GO:0060235 | lens induction in camera-type eye |
| GO:0045665 | negative regulation of neuron differentiation |
| GO:0045892 | negative regulation of transcription, DNA-templated |
| GO:0030178 | negative regulation of Wnt signaling pathway |
| GO:0014016 | neuroblast differentiation |
| GO:0097402 | neuroblast migration |
| GO:0003404 | optic vesicle morphogenesis |
| GO:0021983 | pituitary gland development |
| GO:0006606 | protein import into nucleus |
| GO:0009946 | proximal/distal axis specification |
| GO:1901987 | regulation of cell cycle phase transition |
| GO:0061074 | regulation of neural retina development |
| GO:1902692 | regulation of neuroblast proliferation |
| GO:0021978 | telencephalon regionalization |
| PROSITE ID | PROSITE Term |
|---|---|
| PS50071 | HOMEOBOX_2 |