| Tag | Content |
|---|---|
| Uniprot ID | Q6PCA5 |
| Entrez ID | |
| Genbank protein ID | AAH59414.1 |
| Genbank nucleotide ID | |
| Ensembl protein ID | ENSDARP00000075254; ENSDARP00000146668; |
| Ensembl nucleotide ID | ENSDARG00000114971; ENSDARG00000058008; |
| Gene name | SIX homeobox 3a |
| Gene symbol | six3a |
| Organism | Danio rerio |
| NCBI taxa ID | 7955 |
| Cleft type | |
| Developmental stage | |
| Data sources | Homology search |
| Reference | |
| Functional description | |
| Sequence | MVFRSPLELY PSHFFLPNFA DRPLLLASSA PSTRSPEDLS MFQLPTLNFS PEQVASVCET 60 LEETGDIERL GRFLWSLPVA PGACEAINKH ESILRARAVV AFHTGNFRDL YHILENHKFT 120 KDSHGKLQAM WLEAHYQEAE KLRGRPLGPV DKYRVRKKFP LPRTIWDGEQ KTHCFKERTR 180 SLLREWYLQD PYPNPSKKRE LAQATGLTPT QVGNWFKNRR QRDRAAAAKN RLQHQAIGQN 240 GMRSLSESGC TPRSSAESPS TAASPTTSVS SMTERVDTGT SILSVTSSDS ECDV 294 |
Abbreviation :
CLO : cleft lip only. CPO : cleft palate only.
CLP : cleft lip and palate. CL/P : cleft lip with/without cleft palate.
For humans: CL/P, CLO, CPO, and CLP. For mice: CLO, CLP, and CPO.
| Relation | Gene symbol | Entrez ID | UniProt ID | Cleft type | Developmental stage | Species | Evidence | Details |
|---|---|---|---|---|---|---|---|---|
| 1:1 ortholog | SIX3 | 616756 | E1BMT1 | Bos taurus | Prediction | More>> | ||
| 1:1 ortholog | SIX3 | 102179678 | A0A452E3R7 | Capra hircus | Prediction | More>> | ||
| 1:1 ortholog | SIX3 | 6496 | O95343 | Homo sapiens | Prediction | More>> | ||
| 1:1 ortholog | Six3 | 20473 | Q62233 | CPO | Mus musculus | Publication | More>> | |
| 1:1 ortholog | SIX3 | 470367 | H2QHU7 | Pan troglodytes | Prediction | More>> | ||
| 1:1 ortholog | Six3 | A0A0G2K2C0 | Rattus norvegicus | Prediction | More>> | |||
| 1:1 ortholog | six3a | Q6PCA5 | Danio rerio | Prediction | More>> |
| GO ID | GO Term |
|---|---|
| GO:0005634 | nucleus |
| GO:0005667 | transcription regulator complex |
| GO:0000981 | DNA-binding transcription factor activity, RNA polymerase II-specific |
| GO:0000978 | RNA polymerase II cis-regulatory region sequence-specific DNA binding |
| GO:0007420 | brain development |
| GO:0001654 | eye development |
| GO:0021554 | optic nerve development |
| GO:0021631 | optic nerve morphogenesis |
| GO:0006357 | regulation of transcription by RNA polymerase II |
| PROSITE ID | PROSITE Term |
|---|---|
| PS50071 | HOMEOBOX_2 |