| Tag | Content |
|---|---|
| Uniprot ID | A0A0R4IFV9 |
| Entrez ID | |
| Genbank protein ID | |
| Genbank nucleotide ID | |
| Ensembl protein ID | ENSDARP00000132819 |
| Ensembl nucleotide ID | ENSDARG00000013847 |
| Gene name | Receptor protein-tyrosine kinase |
| Gene symbol | egfra |
| Organism | Danio rerio |
| NCBI taxa ID | 7955 |
| Cleft type | |
| Developmental stage | |
| Data sources | Homology search |
| Reference | |
| Functional description | |
| Sequence | MAGPTEIGLF FTLLLSGSFC ATPEKKVCQG ANNKLTLLGT VEDHYQVLLR MYRNCTVVLE 60 NLEITHITEK YDLSFLKSIQ EVGGYVLIAV NTVSKIPLEN LRIIRGHSLY EDKFALAVLV 120 NYNNSIEQGV KELPLTSLTE ILKGGVRFNM NNHLCNVGTI EWADILNMKS LPTIVSHNIS 180 YGKNCGKCDP SCFNGSCWGT GPDKCQRMTK VICAEQCSGR CKGPRPIDCC NEHCAAGCTG 240 PRPTDCLACK DFQDEGTCKD ACPRLMLYDP NTHQLAPNPY GKYSFGATCI KTCPHNYVVT 300 DHGACVRTCS PGTYEVDEGG VRKCKRCEGL CPKVCNGLGM GPLANVLSIN ATNIDSFENC 360 TKISGNVAIL STTFRGDPHT NTSGLDPAKL SVLSTVKEIT GYLMIQLWPE SMQSLSAFEN 420 LEVIRGRTKT QGTYSFAVTK TAITHLGMRS LREISDGDVS IVKNKNLCYS SPEHWKRLFK 480 SKQQSVKMIE NMDAATCANQ NSTCNEMCTA DGCWGPGPTM CFGCEHYSRG KHCVASCNLL 540 NGEPREYEVN KTCMECDPEC LLMNETQTCN GPGPDKCTVC ANYKDGPHCV HRCPQGVPGE 600 KDTLIWKYAD VTHVCQPCHE NCTQGCTGPD LKDCKDFKSS GLPMIAAGVV GGLLAFVILA 660 LGVAVLLRRR HIRRKRTLRR LLQERELVEP LTPSGEAPNQ ALLRILKETE FKKIKVLGSG 720 AFGTVHKGLW VPEGENVKIP VAIKVLREAT SPKANKEIMD EAYVMASVEH PHVCRLLGIC 780 LTSTVQLITQ LMPYGCLLDY VRENKDRIGS QHLLNWCVQI AKGMNYLEER HLVHRDLAAR 840 NVLVKTPQHV KITDFGLAKL LNADEKEYHA DGGKVPIKWM ALESIQHRTY THQSDVWSYG 900 VTVWELMTFG TKPYDGIPAS EIAGVLEKGE RLPQPPICTI DVYMIMVKCW MIDAESRPRF 960 RELIAEFTKM ARDPSRYLVI QGDDRMHLPS PSDSKFYRSL MSGELDEAVD ADEYLVPNHS 1020 FFSSPSTSRT QLLHSVSLNS SFGNCNSRNG NGYPVRENSM VLRYIPDPTE RFQEGDFQPA 1080 PGYNEYMNQN ESSMINPVYQ QPHGPPRTLL HSSPALDETE EEYLNCFKSP APASVVEYLN 1140 TSHTQLLSTK PFFSMDNPDY QQDFCPLELK THTNGHLPAA QNQEYMGLEV H 1191 |
Abbreviation :
CLO : cleft lip only. CPO : cleft palate only.
CLP : cleft lip and palate. CL/P : cleft lip with/without cleft palate.
For humans: CL/P, CLO, CPO, and CLP. For mice: CLO, CLP, and CPO.
| Relation | Gene symbol | Entrez ID | UniProt ID | Cleft type | Developmental stage | Species | Evidence | Details |
|---|---|---|---|---|---|---|---|---|
| 1:1 ortholog | EGFR | 1956 | P00533 | Homo sapiens | Prediction | More>> | ||
| 1:1 ortholog | Egfr | 13649 | Q01279 | CPO | E14.5 | Mus musculus | Publication | More>> |
| 1:1 ortholog | EGFR | H2QUL1 | Pan troglodytes | Prediction | More>> | |||
| 1:1 ortholog | EGFR | A0A5G2QBP1 | Sus scrofa | Prediction | More>> | |||
| 1:1 ortholog | Egfr | G3V6K6 | Rattus norvegicus | Prediction | More>> | |||
| 1:1 ortholog | egfra | A0A0R4IFV9 | Danio rerio | Prediction | More>> |
| GO ID | GO Term |
|---|---|
| GO:0009925 | basal plasma membrane |
| GO:0005887 | integral component of plasma membrane |
| GO:0043235 | receptor complex |
| GO:0005524 | ATP binding |
| GO:0048408 | epidermal growth factor binding |
| GO:0005006 | epidermal growth factor-activated receptor activity |
| GO:0004714 | transmembrane receptor protein tyrosine kinase activity |
| GO:0072554 | blood vessel lumenization |
| GO:0030154 | cell differentiation |
| GO:0007275 | multicellular organism development |
| GO:0043066 | negative regulation of apoptotic process |
| GO:0008284 | positive regulation of cell population proliferation |
| GO:0050679 | positive regulation of epithelial cell proliferation |
| GO:0033674 | positive regulation of kinase activity |
| GO:0007169 | transmembrane receptor protein tyrosine kinase signaling pathway |
| InterPro ID | InterPro Term |
|---|---|
| IPR006211 | Furin-like_Cys-rich_dom |
| IPR006212 | Furin_repeat |
| IPR032778 | GF_recep_IV |
| IPR009030 | Growth_fac_rcpt_cys_sf |
| IPR011009 | Kinase-like_dom_sf |
| IPR000719 | Prot_kinase_dom |
| IPR017441 | Protein_kinase_ATP_BS |
| IPR000494 | Rcpt_L-dom |
| IPR036941 | Rcpt_L-dom_sf |
| IPR001245 | Ser-Thr/Tyr_kinase_cat_dom |
| IPR008266 | Tyr_kinase_AS |
| IPR020635 | Tyr_kinase_cat_dom |
| IPR016245 | Tyr_kinase_EGF/ERB/XmrK_rcpt |