| Tag | Content |
|---|---|
| Uniprot ID | G3V6K6 |
| Entrez ID | |
| Genbank protein ID | EDL97896.1 |
| Genbank nucleotide ID | |
| Ensembl protein ID | ENSRNOP00000006087 |
| Ensembl nucleotide ID | ENSRNOG00000004332 |
| Gene name | Receptor protein-tyrosine kinase |
| Gene symbol | Egfr |
| Organism | Rattus norvegicus |
| NCBI taxa ID | 10116 |
| Cleft type | |
| Developmental stage | |
| Data sources | Homology search |
| Reference | |
| Functional description | |
| Sequence | MRPSGTARTK LLLLLAALCA AGGALEEKKV CQGTSNRLTQ LGTFEDHFLS LQRMFNNCEV 60 VLGNLEITYV QRNYDLSFLK TIQEVAGYVL IALNTVERIP LENLQIIRGN ALYENTYALA 120 VLSNYGTNKT GLRELPMRNL QEILIGAVRF SNNPILCNME TIQWRDIVQD VFLSNMSMDV 180 QRHLTGCPKC DPSCPNGSCW GRGEENCQKL TKIICAQQCS RRCRGRSPSD CCHNQCAAGC 240 TGPRESDCLV CHRFRDEATC KDTCPPLMLY NPTTYQMDVN PEGKYSFGAT CVKKCPRNYV 300 VTDHGSCVRA CGPDYYEVEE DGVSKCKKCD GPCRKVCNGI GIGEFKDTLS INATNIKHFK 360 YCTAISGDLH ILPVAFKGDS FTRTPPLDPR ELEILKTVKE ITGFLLIQAW PENWTDLHAF 420 ENLEIIRGRT KQHGQFSLAV VGLNITSLGL RSLKEISDGD VIISGNRNLC YANTINWKKL 480 FGTPNQKTKI MNNRAEKDCK ATNHVCNPLC SSEGCWGPEP TDCVSCQNVS RGRECVDKCN 540 ILEGEPREFV ENSECIQCHP ECLPQTMNIT CTGRGPDNCI KCAHYVDGPH CVKTCPSGIM 600 GENNTLVWKF ADANNVCHLC HANCTYGCAG PGLKGCQQPE GPKIPSIATG IVGGLLFIVV 660 VALGIGLFMR RRHIVRKRTL RRLLQERELV EPLTPSGEAP NQAHLRILKE TEFKKIKVLG 720 SGAFGTVYKG LWIPEGEKVK IPVAIKELRE ATSPKANKEI LDEAYVMASV DNPHVCRLLG 780 ICLTSTVQLI TQLMPYGCLL DYVREHKDNI GSQYLLNWCV QIAKGMNYLE DRRLVHRDLA 840 ARNVLVKTPQ HVKITDFGLA KLLGAEEKEY HAEGGKVPIK WMALESILHR IYTHQSDVWS 900 YGVTVWELMT FGSKPYDGIP ASEISSILEK GERLPQPPIC TIDVYMIMVK CWMIDADSRP 960 KFRELILEFS KMARDPQRYL VIQGDERMHL PSPTDSNFYR ALMEEEDMED VVDADEYLIP 1020 QQGFFNSPST SRTPLLSSLS ANSNSSAVAC INRNGSCRVK EDAFLQRYSS DPTSVLTEDN 1080 IDDTFLPVPE YINQSVPKRP AGSVQNPVYH NQPLHPAPGR DLHYQNPHSN AVSNPEYLNT 1140 AQPTCLSSGF DSSALWIQKG SHQMSLDNPD YQQDFFPKEA KPNGIFKGPT AENAEYLRVA 1200 PPSSEFIGA 1209 |
Abbreviation :
CLO : cleft lip only. CPO : cleft palate only.
CLP : cleft lip and palate. CL/P : cleft lip with/without cleft palate.
For humans: CL/P, CLO, CPO, and CLP. For mice: CLO, CLP, and CPO.
| Relation | Gene symbol | Entrez ID | UniProt ID | Cleft type | Developmental stage | Species | Evidence | Details |
|---|---|---|---|---|---|---|---|---|
| 1:1 ortholog | EGFR | 1956 | P00533 | Homo sapiens | Prediction | More>> | ||
| 1:1 ortholog | Egfr | 13649 | Q01279 | CPO | E14.5 | Mus musculus | Publication | More>> |
| 1:1 ortholog | EGFR | H2QUL1 | Pan troglodytes | Prediction | More>> | |||
| 1:1 ortholog | EGFR | A0A5G2QBP1 | Sus scrofa | Prediction | More>> | |||
| 1:1 ortholog | Egfr | G3V6K6 | Rattus norvegicus | Prediction | More>> | |||
| 1:1 ortholog | egfra | A0A0R4IFV9 | Danio rerio | Prediction | More>> |
| GO ID | GO Term |
|---|---|
| GO:0016324 | apical plasma membrane |
| GO:0009925 | basal plasma membrane |
| GO:0016323 | basolateral plasma membrane |
| GO:0009986 | cell surface |
| GO:0005737 | cytoplasm |
| GO:0031901 | early endosome membrane |
| GO:0030139 | endocytic vesicle |
| GO:0005768 | endosome |
| GO:0010008 | endosome membrane |
| GO:0005887 | integral component of plasma membrane |
| GO:0016020 | membrane |
| GO:0045121 | membrane raft |
| GO:0097489 | multivesicular body, internal vesicle lumen |
| GO:0005634 | nucleus |
| GO:0048471 | perinuclear region of cytoplasm |
| GO:0005886 | plasma membrane |
| GO:0032991 | protein-containing complex |
| GO:0043235 | receptor complex |
| GO:0045202 | synapse |
| GO:0051015 | actin filament binding |
| GO:0005524 | ATP binding |
| GO:0005516 | calmodulin binding |
| GO:0003682 | chromatin binding |
| GO:0019899 | enzyme binding |
| GO:0048408 | epidermal growth factor binding |
| GO:0005006 | epidermal growth factor-activated receptor activity |
| GO:0042802 | identical protein binding |
| GO:0005178 | integrin binding |
| GO:0016301 | kinase activity |
| GO:0030235 | nitric-oxide synthase regulator activity |
| GO:0019901 | protein kinase binding |
| GO:0019903 | protein phosphatase binding |
| GO:0004713 | protein tyrosine kinase activity |
| GO:0044877 | protein-containing complex binding |
| GO:0005102 | signaling receptor binding |
| GO:0004714 | transmembrane receptor protein tyrosine kinase activity |
| GO:0004888 | transmembrane signaling receptor activity |
| GO:0031625 | ubiquitin protein ligase binding |
| GO:0000186 | activation of MAPKK activity |
| GO:0048143 | astrocyte activation |
| GO:0030154 | cell differentiation |
| GO:0000902 | cell morphogenesis |
| GO:0008283 | cell population proliferation |
| GO:0007166 | cell surface receptor signaling pathway |
| GO:0098609 | cell-cell adhesion |
| GO:0071230 | cellular response to amino acid stimulus |
| GO:0071276 | cellular response to cadmium ion |
| GO:0071549 | cellular response to dexamethasone stimulus |
| GO:0035690 | cellular response to drug |
| GO:0071364 | cellular response to epidermal growth factor stimulus |
| GO:0071392 | cellular response to estradiol stimulus |
| GO:0071363 | cellular response to growth factor stimulus |
| GO:0071260 | cellular response to mechanical stimulus |
| GO:0034614 | cellular response to reactive oxygen species |
| GO:0021795 | cerebral cortex cell migration |
| GO:0007623 | circadian rhythm |
| GO:0048546 | digestive tract morphogenesis |
| GO:0016101 | diterpenoid metabolic process |
| GO:0001892 | embryonic placenta development |
| GO:0007173 | epidermal growth factor receptor signaling pathway |
| GO:0008544 | epidermis development |
| GO:0061029 | eyelid development in camera-type eye |
| GO:0001942 | hair follicle development |
| GO:0042743 | hydrogen peroxide metabolic process |
| GO:0035556 | intracellular signal transduction |
| GO:0007611 | learning or memory |
| GO:0001889 | liver development |
| GO:0097421 | liver regeneration |
| GO:0030324 | lung development |
| GO:0010960 | magnesium ion homeostasis |
| GO:0007494 | midgut development |
| GO:0060571 | morphogenesis of an epithelial fold |
| GO:0007275 | multicellular organism development |
| GO:0043066 | negative regulation of apoptotic process |
| GO:1905208 | negative regulation of cardiocyte differentiation |
| GO:0045930 | negative regulation of mitotic cell cycle |
| GO:0042177 | negative regulation of protein catabolic process |
| GO:0048812 | neuron projection morphogenesis |
| GO:0042698 | ovulation cycle |
| GO:0038083 | peptidyl-tyrosine autophosphorylation |
| GO:0018108 | peptidyl-tyrosine phosphorylation |
| GO:0097755 | positive regulation of blood vessel diameter |
| GO:0045780 | positive regulation of bone resorption |
| GO:0090263 | positive regulation of canonical Wnt signaling pathway |
| GO:0030307 | positive regulation of cell growth |
| GO:0030335 | positive regulation of cell migration |
| GO:0008284 | positive regulation of cell population proliferation |
| GO:0045737 | positive regulation of cyclin-dependent protein serine/threonine kinase activity |
| GO:0045739 | positive regulation of DNA repair |
| GO:0045740 | positive regulation of DNA replication |
| GO:0050679 | positive regulation of epithelial cell proliferation |
| GO:0070374 | positive regulation of ERK1 and ERK2 cascade |
| GO:0048146 | positive regulation of fibroblast proliferation |
| GO:1900087 | positive regulation of G1/S transition of mitotic cell cycle |
| GO:0050729 | positive regulation of inflammatory response |
| GO:0033674 | positive regulation of kinase activity |
| GO:0043406 | positive regulation of MAP kinase activity |
| GO:1901224 | positive regulation of NIK/NF-kappaB signaling |
| GO:0010750 | positive regulation of nitric oxide mediated signal transduction |
| GO:0033138 | positive regulation of peptidyl-serine phosphorylation |
| GO:0042327 | positive regulation of phosphorylation |
| GO:1903800 | positive regulation of production of miRNAs involved in gene silencing by miRNA |
| GO:1902722 | positive regulation of prolactin secretion |
| GO:0051897 | positive regulation of protein kinase B signaling |
| GO:1900020 | positive regulation of protein kinase C activity |
| GO:1903078 | positive regulation of protein localization to plasma membrane |
| GO:0001934 | positive regulation of protein phosphorylation |
| GO:0048661 | positive regulation of smooth muscle cell proliferation |
| GO:0032930 | positive regulation of superoxide anion generation |
| GO:0051968 | positive regulation of synaptic transmission, glutamatergic |
| GO:0045944 | positive regulation of transcription by RNA polymerase II |
| GO:0045893 | positive regulation of transcription, DNA-templated |
| GO:0045907 | positive regulation of vasoconstriction |
| GO:0046777 | protein autophosphorylation |
| GO:0006898 | receptor-mediated endocytosis |
| GO:0042127 | regulation of cell population proliferation |
| GO:0070372 | regulation of ERK1 and ERK2 cascade |
| GO:0046328 | regulation of JNK cascade |
| GO:0050999 | regulation of nitric-oxide synthase activity |
| GO:0050730 | regulation of peptidyl-tyrosine phosphorylation |
| GO:0014066 | regulation of phosphatidylinositol 3-kinase signaling |
| GO:0051592 | response to calcium ion |
| GO:0033590 | response to cobalamin |
| GO:0032355 | response to estradiol |
| GO:0033594 | response to hydroxyisoflavone |
| GO:0033993 | response to lipid |
| GO:0014070 | response to organic cyclic compound |
| GO:0006970 | response to osmotic stress |
| GO:0006979 | response to oxidative stress |
| GO:0070141 | response to UV-A |
| GO:0007435 | salivary gland morphogenesis |
| GO:0007165 | signal transduction |
| GO:0043586 | tongue development |
| GO:0006412 | translation |
| GO:0007169 | transmembrane receptor protein tyrosine kinase signaling pathway |
| GO:0042060 | wound healing |
| InterPro ID | InterPro Term |
|---|---|
| IPR006211 | Furin-like_Cys-rich_dom |
| IPR006212 | Furin_repeat |
| IPR032778 | GF_recep_IV |
| IPR009030 | Growth_fac_rcpt_cys_sf |
| IPR011009 | Kinase-like_dom_sf |
| IPR000719 | Prot_kinase_dom |
| IPR017441 | Protein_kinase_ATP_BS |
| IPR000494 | Rcpt_L-dom |
| IPR036941 | Rcpt_L-dom_sf |
| IPR001245 | Ser-Thr/Tyr_kinase_cat_dom |
| IPR008266 | Tyr_kinase_AS |
| IPR020635 | Tyr_kinase_cat_dom |
| IPR016245 | Tyr_kinase_EGF/ERB/XmrK_rcpt |