| Tag | Content |
|---|---|
| Uniprot ID | A0A5G2QBP1 |
| Entrez ID | |
| Genbank protein ID | |
| Genbank nucleotide ID | |
| Ensembl protein ID | ENSSSCP00000061918 |
| Ensembl nucleotide ID | ENSSSCG00000022126 |
| Gene name | Receptor protein-tyrosine kinase |
| Gene symbol | EGFR |
| Organism | Sus scrofa |
| NCBI taxa ID | 9823 |
| Cleft type | |
| Developmental stage | |
| Data sources | Homology search |
| Reference | |
| Functional description | |
| Sequence | MLRAPLVPMH SLNKHFPKAR ICARVCQGTS NKLTQLGTFE DHFLSLQRMF NNCEVVLGNL 60 EITYMQNSYN LSFLKTIQEV AGYVLIALNT VEKIPLENLQ IIRGNVLYEN THALAVLSNY 120 GANKTGLREL PMRNLQEILQ GAVRFSNNPA LCHAESIQWR DIVNSDFLSN MSMDFQSQLG 180 SCPKCDPGCL NGSCWGAGKE NCQKLTKVIC AQQCSGRCRG RSPSDCCHNQ CAAGCTGPRE 240 SDCLVCRRFR DEATCKDTCP PLMLYNPTTY QMDVNPLGKY SFGATCVKKC PRNYVVTDHG 300 SCVRACSSDS YEVEEDGVRK CKKCDGPCGK VCNGIGIGEF KDTLSINATN IKHFRNCTSI 360 SGDLHILPVA FRGDSFTRTP PLDPKELDIL KTVKEITGFL LIQAWPENRT GLHAFENLEI 420 IRGRTKQHGQ FSLAVVGLDI ASLGLRSLKE ISDGDVIVSG NRNLCYANTI SWKKLFGTAS 480 QKTKIINNRS EKECKAMGHI CNPLCSSEGC WGPEPRDCMS CRNFSRGKEC VEKCNVLEGE 540 PREFVENAEC VQCHPECLPQ AKNVTCMGRG PDSCVRCAHY IDGPHCVKTC PAGIAGENST 600 LIWKFADANH VCHLCHPNCT YGCVGPGLEG CAVDRPKIPS IATGIVGGLL LAVVLALGVG 660 LFLRRRHIVR KRTLRRLLQE RELVEPLTPS GEAPNQALLR ILKETEFKKV KVLGSGAFGT 720 VYKGLWIPEG EKVKIPVAIK ELREATSPKA NKEILDEAYV MASVDNPHVC RLLGICLTST 780 VQLITQLMPF GCLLDYVREH KDNIGSQHLL NWCVQIAKGM NYLEDRRLVH RDLAARNVLV 840 KTPQHVKITD FGLAKLLGAE EKEYHAEGGK VPIKWLALES ILHRVYTHQS DVWSYGVTVW 900 ELMTFGSKPY DGIPASEIST VLEKGERLPQ PPICTIDVYM IMVKCWMIDA DSRPKFRELI 960 IEFSKMARDP QRYLVIQGDE RMHLPSPTDS NFYRALMDEE DMEDVVDADE YLVPQQGFFH 1020 SPATSRTPLL SSLSATSSTP AVACVDRNGQ SYPLKEDSFL QRYSSDPTGA LTEDSLDDTF 1080 LPAPEYVNQS VPKRPAGSVQ NPVYHNQPLS AAPGRDPHYQ NSHSNAVGNP EYLNTPRPAC 1140 INGGLDGPAF WAQTGSHQIN LDNPDYQQAF FPKEAKSNGI CKGPAAENAE YLRAAPASSD 1200 LTGA 1204 |
Abbreviation :
CLO : cleft lip only. CPO : cleft palate only.
CLP : cleft lip and palate. CL/P : cleft lip with/without cleft palate.
For humans: CL/P, CLO, CPO, and CLP. For mice: CLO, CLP, and CPO.
| Relation | Gene symbol | Entrez ID | UniProt ID | Cleft type | Developmental stage | Species | Evidence | Details |
|---|---|---|---|---|---|---|---|---|
| 1:1 ortholog | EGFR | 1956 | P00533 | Homo sapiens | Prediction | More>> | ||
| 1:1 ortholog | Egfr | 13649 | Q01279 | CPO | E14.5 | Mus musculus | Publication | More>> |
| 1:1 ortholog | EGFR | H2QUL1 | Pan troglodytes | Prediction | More>> | |||
| 1:1 ortholog | EGFR | A0A5G2QBP1 | Sus scrofa | Prediction | More>> | |||
| 1:1 ortholog | Egfr | G3V6K6 | Rattus norvegicus | Prediction | More>> | |||
| 1:1 ortholog | egfra | A0A0R4IFV9 | Danio rerio | Prediction | More>> |
| GO ID | GO Term |
|---|---|
| GO:0016021 | integral component of membrane |
| GO:0005524 | ATP binding |
| GO:0004714 | transmembrane receptor protein tyrosine kinase activity |
| GO:0007169 | transmembrane receptor protein tyrosine kinase signaling pathway |
| InterPro ID | InterPro Term |
|---|---|
| IPR006211 | Furin-like_Cys-rich_dom |
| IPR006212 | Furin_repeat |
| IPR032778 | GF_recep_IV |
| IPR009030 | Growth_fac_rcpt_cys_sf |
| IPR011009 | Kinase-like_dom_sf |
| IPR000719 | Prot_kinase_dom |
| IPR017441 | Protein_kinase_ATP_BS |
| IPR000494 | Rcpt_L-dom |
| IPR036941 | Rcpt_L-dom_sf |
| IPR001245 | Ser-Thr/Tyr_kinase_cat_dom |
| IPR008266 | Tyr_kinase_AS |
| IPR020635 | Tyr_kinase_cat_dom |
| IPR016245 | Tyr_kinase_EGF/ERB/XmrK_rcpt |