| Tag | Content |
|---|---|
| Uniprot ID | H2QUL1 |
| Entrez ID | |
| Genbank protein ID | |
| Genbank nucleotide ID | |
| Ensembl protein ID | ENSPTRP00000032807 |
| Ensembl nucleotide ID | ENSPTRG00000019196 |
| Gene name | Receptor protein-tyrosine kinase |
| Gene symbol | EGFR |
| Organism | Pan troglodytes |
| NCBI taxa ID | 9598 |
| Cleft type | |
| Developmental stage | |
| Data sources | Homology search |
| Reference | |
| Functional description | |
| Sequence | KSIEESASVL ILAMVCALPP VCQGTSNKLT QLGTFEDHFL SLQRMFNNCE VVLGNLEITY 60 VQRNYDLSFL KTIQEVAGYV LIALNTVERI PLENLQIIRG NMYYENSYAL AVLSNYDANK 120 TGLKELPMRN LQEILHGAVR FSNNPALCNV ESIQWRDIVS SDFLSNMSMD FQNHLGSCQK 180 CDPSCPNGSC WGAGEENCQK LTKIICAQQC SGRCRGKSPS DCCHNQCAAG CTGPRESDCL 240 VCRKFRDEAT CKDTCPPLML YNPTTYQMDV NPEGKYSFGA TCVKKCPRNY VVTDHGSCVR 300 ACGADSYEME EDGVRKCKKC EGPCRKVCNG IGIGEFKDTL SINATNIKHF KNCTSISGDL 360 HILPVAFRGD SFTHTPPLDP QELDILKTVK EITGFLLIQA WPENRTDLHA FENLEIIRGR 420 TKQHGQFSLA VVSLNITSLG LRSLKEISDG DVIISGNKNL CYANTINWKK LFGTSGQKTK 480 IISNRGENSC KATGQVCHAL CSPEGCWGPE PRDCVSCRNV SRGRECVDKC NILEGEPREF 540 VENSECIQCH PECLPQAMNI TCTGRGPDNC IQCAHYIDGP HCVKTCPAGV MGENNTLVWK 600 YADAGHVCHL CHPNCTYGPK IPSIATGMVG ALLLLLVVAL GIGLFMRRRH IVRKRTLRRL 660 LQERELVEPL TPSGEAPNQA LLRILKETEF KKIKVLGSGA FGTVYKGLWI PEGEKVKIPV 720 AIKELREATS PKANKEILDE AYVMASVDNP HVCRLLGICL TSTVQLITQL MPFGCLLDYV 780 REHKDNIGSQ YLLNWCVQIA KGMNYLEDRR LVHRDLAARN VLVKTPQHVK ITDFGLAKLL 840 GAEEKEYHAE GGKVPIKWMA LESILHRIYT HQSDVWSYGV TVWELMTFGS KPYDGIPASE 900 ISSILEKGER LPQPPICTID VYMIMVKCWM IDADSRPKFR ELIIEFSKMA RDPQRYLVIQ 960 GDERMHLPSP TDSNFYRALM DEEDMDDVVD ADEYLIPQQG FFSSPSTSRT PLLSSLSATS 1020 NNSTMACIDR NGLQSCPIKE DSFLQRYSSD PTGALTEDSI DDTFLPVPGE WLVWKQSCSS 1080 ASSTHSAACP SQVLPPASPE GETVADLQKQ |
Abbreviation :
CLO : cleft lip only. CPO : cleft palate only.
CLP : cleft lip and palate. CL/P : cleft lip with/without cleft palate.
For humans: CL/P, CLO, CPO, and CLP. For mice: CLO, CLP, and CPO.
| Relation | Gene symbol | Entrez ID | UniProt ID | Cleft type | Developmental stage | Species | Evidence | Details |
|---|---|---|---|---|---|---|---|---|
| 1:1 ortholog | EGFR | 1956 | P00533 | Homo sapiens | Prediction | More>> | ||
| 1:1 ortholog | Egfr | 13649 | Q01279 | CPO | E14.5 | Mus musculus | Publication | More>> |
| 1:1 ortholog | EGFR | H2QUL1 | Pan troglodytes | Prediction | More>> | |||
| 1:1 ortholog | EGFR | A0A5G2QBP1 | Sus scrofa | Prediction | More>> | |||
| 1:1 ortholog | Egfr | G3V6K6 | Rattus norvegicus | Prediction | More>> | |||
| 1:1 ortholog | egfra | A0A0R4IFV9 | Danio rerio | Prediction | More>> |
| GO ID | GO Term |
|---|---|
| GO:0016021 | integral component of membrane |
| GO:0005524 | ATP binding |
| GO:0004714 | transmembrane receptor protein tyrosine kinase activity |
| GO:0007169 | transmembrane receptor protein tyrosine kinase signaling pathway |
| InterPro ID | InterPro Term |
|---|---|
| IPR006211 | Furin-like_Cys-rich_dom |
| IPR006212 | Furin_repeat |
| IPR032778 | GF_recep_IV |
| IPR009030 | Growth_fac_rcpt_cys_sf |
| IPR011009 | Kinase-like_dom_sf |
| IPR000719 | Prot_kinase_dom |
| IPR017441 | Protein_kinase_ATP_BS |
| IPR000494 | Rcpt_L-dom |
| IPR036941 | Rcpt_L-dom_sf |
| IPR001245 | Ser-Thr/Tyr_kinase_cat_dom |
| IPR008266 | Tyr_kinase_AS |
| IPR020635 | Tyr_kinase_cat_dom |
| IPR016245 | Tyr_kinase_EGF/ERB/XmrK_rcpt |