| Tag | Content |
|---|---|
| Uniprot ID | Q01279 |
| Entrez ID | 13649 |
| Genbank protein ID | CAA78249.1; AAA17899.1; CAA42219.1; CAA55587.1; AAA53029.1; |
| Genbank nucleotide ID | NM_207655.2 |
| Ensembl protein ID | ENSMUSP00000020329 |
| Ensembl nucleotide ID | ENSMUSG00000020122 |
| Gene name | Epidermal growth factor receptor |
| Gene symbol | Egfr |
| Organism | Mus musculus |
| NCBI taxa ID | 10090 |
| Cleft type | CPO |
| Developmental stage | E14.5 |
| Data sources | Manually collected |
| Reference | 10319864; 7630400; |
| Functional description | Receptor tyrosine kinase binding ligands of the EGF family and activating several signaling cascades to convert extracellular cues into appropriate cellular responses (PubMed:8404850). Known ligands include EGF, TGFA/TGF-alpha, AREG, epigen/EPGN, BTC/betacellulin, epiregulin/EREG and HBEGF/heparin-binding EGF. Ligand binding triggers receptor homo- and/or heterodimerization and autophosphorylation on key cytoplasmic residues. The phosphorylated receptor recruits adapter proteins like GRB2 which in turn activates complex downstream signaling cascades. Activates at least 4 major downstream signaling cascades including the RAS-RAF-MEK-ERK, PI3 kinase-AKT, PLCgamma-PKC and STATs modules. May also activate the NF-kappa-B signaling cascade. Also directly phosphorylates other proteins like RGS16, activating its GTPase activity and probably coupling the EGF receptor signaling to the G protein-coupled receptor signaling. Also phosphorylates MUC1 and increases its interaction with SRC and CTNNB1/beta-catenin (By similarity). Positively regulates cell migration via interaction with CCDC88A/GIV which retains EGFR at the cell membrane following ligand stimulation, promoting EGFR signaling which triggers cell migration (By similarity). Plays a role in enhancing learning and memory performance (PubMed:20639532). |
| Sequence | MRPSGTARTT LLVLLTALCA AGGALEEKKV CQGTSNRLTQ LGTFEDHFLS LQRMYNNCEV 60 VLGNLEITYV QRNYDLSFLK TIQEVAGYVL IALNTVERIP LENLQIIRGN ALYENTYALA 120 ILSNYGTNRT GLRELPMRNL QEILIGAVRF SNNPILCNMD TIQWRDIVQN VFMSNMSMDL 180 QSHPSSCPKC DPSCPNGSCW GGGEENCQKL TKIICAQQCS HRCRGRSPSD CCHNQCAAGC 240 TGPRESDCLV CQKFQDEATC KDTCPPLMLY NPTTYQMDVN PEGKYSFGAT CVKKCPRNYV 300 VTDHGSCVRA CGPDYYEVEE DGIRKCKKCD GPCRKVCNGI GIGEFKDTLS INATNIKHFK 360 YCTAISGDLH ILPVAFKGDS FTRTPPLDPR ELEILKTVKE ITGFLLIQAW PDNWTDLHAF 420 ENLEIIRGRT KQHGQFSLAV VGLNITSLGL RSLKEISDGD VIISGNRNLC YANTINWKKL 480 FGTPNQKTKI MNNRAEKDCK AVNHVCNPLC SSEGCWGPEP RDCVSCQNVS RGRECVEKCN 540 ILEGEPREFV ENSECIQCHP ECLPQAMNIT CTGRGPDNCI QCAHYIDGPH CVKTCPAGIM 600 GENNTLVWKY ADANNVCHLC HANCTYGCAG PGLQGCEVWP SGPKIPSIAT GIVGGLLFIV 660 VVALGIGLFM RRRHIVRKRT LRRLLQEREL VEPLTPSGEA PNQAHLRILK ETEFKKIKVL 720 GSGAFGTVYK GLWIPEGEKV KIPVAIKELR EATSPKANKE ILDEAYVMAS VDNPHVCRLL 780 GICLTSTVQL ITQLMPYGCL LDYVREHKDN IGSQYLLNWC VQIAKGMNYL EDRRLVHRDL 840 AARNVLVKTP QHVKITDFGL AKLLGAEEKE YHAEGGKVPI KWMALESILH RIYTHQSDVW 900 SYGVTVWELM TFGSKPYDGI PASDISSILE KGERLPQPPI CTIDVYMIMV KCWMIDADSR 960 PKFRELILEF SKMARDPQRY LVIQGDERMH LPSPTDSNFY RALMDEEDME DVVDADEYLI 1020 PQQGFFNSPS TSRTPLLSSL SATSNNSTVA CINRNGSCRV KEDAFLQRYS SDPTGAVTED 1080 NIDDAFLPVP EYVNQSVPKR PAGSVQNPVY HNQPLHPAPG RDLHYQNPHS NAVGNPEYLN 1140 TAQPTCLSSG FNSPALWIQK GSHQMSLDNP DYQQDFFPKE TKPNGIFKGP TAENAEYLRV 1200 APPSSEFIGA |
Abbreviation :
CLO : cleft lip only. CPO : cleft palate only.
CLP : cleft lip and palate. CL/P : cleft lip with/without cleft palate.
For humans: CL/P, CLO, CPO, and CLP. For mice: CLO, CLP, and CPO.
| Relation | Gene symbol | Entrez ID | UniProt ID | Cleft type | Developmental stage | Species | Evidence | Details |
|---|---|---|---|---|---|---|---|---|
| 1:1 ortholog | EGFR | 1956 | P00533 | Homo sapiens | Prediction | More>> | ||
| 1:1 ortholog | Egfr | 13649 | Q01279 | CPO | E14.5 | Mus musculus | Publication | More>> |
| 1:1 ortholog | EGFR | H2QUL1 | Pan troglodytes | Prediction | More>> | |||
| 1:1 ortholog | EGFR | A0A5G2QBP1 | Sus scrofa | Prediction | More>> | |||
| 1:1 ortholog | Egfr | G3V6K6 | Rattus norvegicus | Prediction | More>> | |||
| 1:1 ortholog | egfra | A0A0R4IFV9 | Danio rerio | Prediction | More>> |
| GO ID | GO Term | Evidence |
|---|---|---|
| GO:0003682 | chromatin binding | ISS |
| GO:0003682 | chromatin binding | ISO |
| GO:0004713 | protein tyrosine kinase activity | ISS |
| GO:0004713 | protein tyrosine kinase activity | ISO |
| GO:0004714 | transmembrane receptor protein tyrosine kinase activity | IBA |
| GO:0004888 | transmembrane signaling receptor activity | ISO |
| GO:0005006 | epidermal growth factor-activated receptor activity | ISO |
| GO:0005006 | epidermal growth factor-activated receptor activity | IDA |
| GO:0005006 | epidermal growth factor-activated receptor activity | IBA |
| GO:0005102 | signaling receptor binding | ISO |
| GO:0005178 | integrin binding | ISO |
| GO:0005515 | protein binding | IPI |
| GO:0005516 | calmodulin binding | ISO |
| GO:0005524 | ATP binding | IEA |
| GO:0016301 | kinase activity | IDA |
| GO:0019899 | enzyme binding | ISO |
| GO:0019901 | protein kinase binding | ISO |
| GO:0019903 | protein phosphatase binding | ISO |
| GO:0031625 | ubiquitin protein ligase binding | ISO |
| GO:0042802 | identical protein binding | ISO |
| GO:0044877 | protein-containing complex binding | ISO |
| GO:0048408 | epidermal growth factor binding | ISO |
| GO:0048408 | epidermal growth factor binding | IBA |
| GO:0048408 | epidermal growth factor binding | IDA |
| GO:0051015 | actin filament binding | ISO |
| GO:0030235 | nitric-oxide synthase regulator activity | ISO |
| GO ID | GO Term | Evidence |
|---|---|---|
| GO:0000186 | activation of MAPKK activity | ISO |
| GO:0000902 | cell morphogenesis | IGI |
| GO:0001892 | embryonic placenta development | IMP |
| GO:0001934 | positive regulation of protein phosphorylation | ISS |
| GO:0001934 | positive regulation of protein phosphorylation | ISO |
| GO:0001942 | hair follicle development | IMP |
| GO:0001942 | hair follicle development | IGI |
| GO:0006412 | translation | ISO |
| GO:0006970 | response to osmotic stress | IEA |
| GO:0007165 | signal transduction | ISO |
| GO:0007165 | signal transduction | IDA |
| GO:0007166 | cell surface receptor signaling pathway | ISO |
| GO:0007169 | transmembrane receptor protein tyrosine kinase signaling pathway | IBA |
| GO:0007173 | epidermal growth factor receptor signaling pathway | ISO |
| GO:0007173 | epidermal growth factor receptor signaling pathway | IDA |
| GO:0007173 | epidermal growth factor receptor signaling pathway | IMP |
| GO:0007173 | epidermal growth factor receptor signaling pathway | IGI |
| GO:0007275 | multicellular organism development | IBA |
| GO:0007435 | salivary gland morphogenesis | IMP |
| GO:0007494 | midgut development | IEA |
| GO:0007611 | learning or memory | ISO |
| GO:0007623 | circadian rhythm | IEA |
| GO:0008283 | cell population proliferation | ISO |
| GO:0008284 | positive regulation of cell population proliferation | ISO |
| GO:0008284 | positive regulation of cell population proliferation | IDA |
| GO:0008284 | positive regulation of cell population proliferation | IGI |
| GO:0008284 | positive regulation of cell population proliferation | IBA |
| GO:0008544 | epidermis development | IMP |
| GO:0010750 | positive regulation of nitric oxide mediated signal transduction | ISO |
| GO:0010960 | magnesium ion homeostasis | ISO |
| GO:0014066 | regulation of phosphatidylinositol 3-kinase signaling | ISO |
| GO:0016101 | diterpenoid metabolic process | IEA |
| GO:0018108 | peptidyl-tyrosine phosphorylation | ISO |
| GO:0021795 | cerebral cortex cell migration | IMP |
| GO:0030154 | cell differentiation | IBA |
| GO:0030307 | positive regulation of cell growth | ISS |
| GO:0030307 | positive regulation of cell growth | ISO |
| GO:0030324 | lung development | IEA |
| GO:0030335 | positive regulation of cell migration | ISO |
| GO:0032930 | positive regulation of superoxide anion generation | ISO |
| GO:0033138 | positive regulation of peptidyl-serine phosphorylation | ISO |
| GO:0033590 | response to cobalamin | IEA |
| GO:0033594 | response to hydroxyisoflavone | IEA |
| GO:0033674 | positive regulation of kinase activity | IBA |
| GO:0034614 | cellular response to reactive oxygen species | ISO |
| GO:0035556 | intracellular signal transduction | ISO |
| GO:0038083 | peptidyl-tyrosine autophosphorylation | ISO |
| GO:0042060 | wound healing | ISO |
| GO:0042127 | regulation of cell population proliferation | IGI |
| GO:0042177 | negative regulation of protein catabolic process | ISO |
| GO:0042327 | positive regulation of phosphorylation | ISO |
| GO:0042698 | ovulation cycle | ISO |
| GO:0042743 | hydrogen peroxide metabolic process | IEA |
| GO:0043066 | negative regulation of apoptotic process | ISO |
| GO:0043066 | negative regulation of apoptotic process | IBA |
| GO:0043406 | positive regulation of MAP kinase activity | ISO |
| GO:0043586 | tongue development | IEA |
| GO:0045737 | positive regulation of cyclin-dependent protein serine/threonine kinase activity | ISO |
| GO:0045739 | positive regulation of DNA repair | ISO |
| GO:0045740 | positive regulation of DNA replication | ISO |
| GO:0045780 | positive regulation of bone resorption | ISO |
| GO:0045893 | positive regulation of transcription, DNA-templated | ISO |
| GO:0045907 | positive regulation of vasoconstriction | ISO |
| GO:0045930 | negative regulation of mitotic cell cycle | ISO |
| GO:0045944 | positive regulation of transcription by RNA polymerase II | ISS |
| GO:0045944 | positive regulation of transcription by RNA polymerase II | ISO |
| GO:0046328 | regulation of JNK cascade | ISO |
| GO:0046777 | protein autophosphorylation | ISO |
| GO:0046777 | protein autophosphorylation | IDA |
| GO:0048143 | astrocyte activation | ISO |
| GO:0048146 | positive regulation of fibroblast proliferation | IMP |
| GO:0048546 | digestive tract morphogenesis | IMP |
| GO:0048661 | positive regulation of smooth muscle cell proliferation | ISO |
| GO:0048812 | neuron projection morphogenesis | ISO |
| GO:0050679 | positive regulation of epithelial cell proliferation | ISO |
| GO:0050679 | positive regulation of epithelial cell proliferation | IBA |
| GO:0050679 | positive regulation of epithelial cell proliferation | IMP |
| GO:0050729 | positive regulation of inflammatory response | ISO |
| GO:0050730 | regulation of peptidyl-tyrosine phosphorylation | ISO |
| GO:0050730 | regulation of peptidyl-tyrosine phosphorylation | IMP |
| GO:0050999 | regulation of nitric-oxide synthase activity | ISO |
| GO:0051592 | response to calcium ion | ISO |
| GO:0051897 | positive regulation of protein kinase B signaling | ISO |
| GO:0051968 | positive regulation of synaptic transmission, glutamatergic | ISO |
| GO:0060571 | morphogenesis of an epithelial fold | IMP |
| GO:0061029 | eyelid development in camera-type eye | IGI |
| GO:0070141 | response to UV-A | ISO |
| GO:0070372 | regulation of ERK1 and ERK2 cascade | ISO |
| GO:0070374 | positive regulation of ERK1 and ERK2 cascade | ISS |
| GO:0070374 | positive regulation of ERK1 and ERK2 cascade | ISO |
| GO:0071230 | cellular response to amino acid stimulus | IDA |
| GO:0071260 | cellular response to mechanical stimulus | IEA |
| GO:0071276 | cellular response to cadmium ion | ISO |
| GO:0071363 | cellular response to growth factor stimulus | IDA |
| GO:0071364 | cellular response to epidermal growth factor stimulus | ISO |
| GO:0071392 | cellular response to estradiol stimulus | ISS |
| GO:0071392 | cellular response to estradiol stimulus | ISO |
| GO:0071549 | cellular response to dexamethasone stimulus | IEA |
| GO:0090263 | positive regulation of canonical Wnt signaling pathway | ISO |
| GO:0097421 | liver regeneration | IEA |
| GO:0097755 | positive regulation of blood vessel diameter | ISO |
| GO:0098609 | cell-cell adhesion | ISO |
| GO:1900020 | positive regulation of protein kinase C activity | ISO |
| GO:1900087 | positive regulation of G1/S transition of mitotic cell cycle | ISO |
| GO:1901224 | positive regulation of NIK/NF-kappaB signaling | ISO |
| GO:1902722 | positive regulation of prolactin secretion | ISO |
| GO:1902966 | positive regulation of protein localization to early endosome | ISS |
| GO:1903078 | positive regulation of protein localization to plasma membrane | ISO |
| GO:1903800 | positive regulation of production of miRNAs involved in gene silencing by miRNA | ISO |
| GO:1905208 | negative regulation of cardiocyte differentiation | ISO |
| GO ID | GO Term | Evidence |
|---|---|---|
| GO:0000139 | Golgi membrane | IEA |
| GO:0005634 | nucleus | ISO |
| GO:0005634 | nucleus | IDA |
| GO:0005737 | cytoplasm | ISO |
| GO:0005768 | endosome | ISS |
| GO:0005768 | endosome | ISO |
| GO:0005789 | endoplasmic reticulum membrane | IEA |
| GO:0005886 | plasma membrane | ISO |
| GO:0005886 | plasma membrane | IDA |
| GO:0005887 | integral component of plasma membrane | IBA |
| GO:0009925 | basal plasma membrane | IBA |
| GO:0009986 | cell surface | ISO |
| GO:0009986 | cell surface | IDA |
| GO:0010008 | endosome membrane | ISO |
| GO:0016020 | membrane | ISO |
| GO:0016323 | basolateral plasma membrane | ISO |
| GO:0016323 | basolateral plasma membrane | IDA |
| GO:0016324 | apical plasma membrane | ISO |
| GO:0030054 | cell junction | ISO |
| GO:0030139 | endocytic vesicle | ISO |
| GO:0030139 | endocytic vesicle | IDA |
| GO:0031901 | early endosome membrane | ISO |
| GO:0031965 | nuclear membrane | IEA |
| GO:0032991 | protein-containing complex | ISO |
| GO:0043235 | receptor complex | IBA |
| GO:0043235 | receptor complex | ISO |
| GO:0045121 | membrane raft | ISO |
| GO:0045202 | synapse | ISO |
| GO:0048471 | perinuclear region of cytoplasm | ISO |
| GO:0048471 | perinuclear region of cytoplasm | IDA |
| GO:0097489 | multivesicular body, internal vesicle lumen | ISO |
| Reactome ID | Reactome Term | Evidence |
|---|---|---|
| R-MMU-1227986 | Signaling by ERBB2 | IEA |
| R-MMU-1236394 | Signaling by ERBB4 | IEA |
| R-MMU-1250196 | SHC1 events in ERBB2 signaling | IEA |
| R-MMU-1257604 | PIP3 activates AKT signaling | IEA |
| R-MMU-1266738 | Developmental Biology | IEA |
| R-MMU-1280215 | Cytokine Signaling in Immune system | IEA |
| R-MMU-157118 | Signaling by NOTCH | IEA |
| R-MMU-162582 | Signal Transduction | IEA |
| R-MMU-168256 | Immune System | IEA |
| R-MMU-177929 | Signaling by EGFR | IEA |
| R-MMU-179812 | GRB2 events in EGFR signaling | IEA |
| R-MMU-180292 | GAB1 signalosome | IEA |
| R-MMU-180336 | SHC1 events in EGFR signaling | IEA |
| R-MMU-182971 | EGFR downregulation | IEA |
| R-MMU-1963642 | PI3K events in ERBB2 signaling | IEA |
| R-MMU-199418 | Negative regulation of the PI3K/AKT network | IEA |
| R-MMU-199991 | Membrane Trafficking | IEA |
| R-MMU-212718 | EGFR interacts with phospholipase C-gamma | IEA |
| R-MMU-2179392 | EGFR Transactivation by Gastrin | IEA |
| R-MMU-372790 | Signaling by GPCR | IEA |
| R-MMU-373760 | L1CAM interactions | IEA |
| R-MMU-388396 | GPCR downstream signalling | IEA |
| R-MMU-416476 | G alpha (q) signalling events | IEA |
| R-MMU-422475 | Axon guidance | IEA |
| R-MMU-445144 | Signal transduction by L1 | IEA |
| R-MMU-5653656 | Vesicle-mediated transport | IEA |
| R-MMU-5673001 | RAF/MAP kinase cascade | IEA |
| R-MMU-5683057 | MAPK family signaling cascades | IEA |
| R-MMU-5684996 | MAPK1/MAPK3 signaling | IEA |
| R-MMU-6785631 | ERBB2 Regulates Cell Motility | IEA |
| R-MMU-6811558 | PI5P, PP2A and IER3 Regulate PI3K/AKT Signaling | IEA |
| R-MMU-881907 | Gastrin-CREB signalling pathway via PKC and MAPK | IEA |
| R-MMU-8847993 | ERBB2 Activates PTK6 Signaling | IEA |
| R-MMU-8848021 | Signaling by PTK6 | IEA |
| R-MMU-8856825 | Cargo recognition for clathrin-mediated endocytosis | IEA |
| R-MMU-8856828 | Clathrin-mediated endocytosis | IEA |
| R-MMU-8857538 | PTK6 promotes HIF1A stabilization | IEA |
| R-MMU-8863795 | Downregulation of ERBB2 signaling | IEA |
| R-MMU-8939211 | ESR-mediated signaling | IEA |
| R-MMU-9006925 | Intracellular signaling by second messengers | IEA |
| R-MMU-9006927 | Signaling by Non-Receptor Tyrosine Kinases | IEA |
| R-MMU-9006931 | Signaling by Nuclear Receptors | IEA |
| R-MMU-9006934 | Signaling by Receptor Tyrosine Kinases | IEA |
| R-MMU-9009391 | Extra-nuclear estrogen signaling | IEA |
| R-MMU-9012852 | Signaling by NOTCH3 | IEA |
| R-MMU-9013507 | NOTCH3 Activation and Transmission of Signal to the Nucleus | IEA |
| R-MMU-9607240 | FLT3 Signaling | IEA |
| Keyword ID | Keyword Term |
|---|---|
| KW-0067 | ATP-binding |
| KW-1003 | Cell membrane |
| KW-0217 | Developmental protein |
| KW-1015 | Disulfide bond |
| KW-0256 | Endoplasmic reticulum |
| KW-0967 | Endosome |
| KW-0325 | Glycoprotein |
| KW-0333 | Golgi apparatus |
| KW-1017 | Isopeptide bond |
| KW-0418 | Kinase |
| KW-0449 | Lipoprotein |
| KW-0472 | Membrane |
| KW-0488 | Methylation |
| KW-0547 | Nucleotide-binding |
| KW-0539 | Nucleus |
| KW-0564 | Palmitate |
| KW-0597 | Phosphoprotein |
| KW-0675 | Receptor |
| KW-1185 | Reference proteome |
| KW-0677 | Repeat |
| KW-0732 | Signal |
| KW-0808 | Transferase |
| KW-0812 | Transmembrane |
| KW-1133 | Transmembrane helix |
| KW-0829 | Tyrosine-protein kinase |
| KW-0832 | Ubl conjugation |
| InterPro ID | InterPro Term |
|---|---|
| IPR006211 | Furin-like_Cys-rich_dom |
| IPR006212 | Furin_repeat |
| IPR032778 | GF_recep_IV |
| IPR009030 | Growth_fac_rcpt_cys_sf |
| IPR011009 | Kinase-like_dom_sf |
| IPR000719 | Prot_kinase_dom |
| IPR017441 | Protein_kinase_ATP_BS |
| IPR000494 | Rcpt_L-dom |
| IPR036941 | Rcpt_L-dom_sf |
| IPR001245 | Ser-Thr/Tyr_kinase_cat_dom |
| IPR008266 | Tyr_kinase_AS |
| IPR020635 | Tyr_kinase_cat_dom |
| IPR016245 | Tyr_kinase_EGF/ERB/XmrK_rcpt |