| Tag | Content |
|---|---|
| Uniprot ID | A0A140TA94 |
| Entrez ID | 117275 |
| Genbank protein ID | EDL78029.1 |
| Genbank nucleotide ID | NM_057134.1 |
| Ensembl protein ID | ENSRNOP00000002394 |
| Ensembl nucleotide ID | ENSRNOG00000001750 |
| Gene name | Chordin |
| Gene symbol | Chrd |
| Organism | Rattus norvegicus |
| NCBI taxa ID | 10116 |
| Cleft type | |
| Developmental stage | |
| Data sources | Homology search |
| Reference | |
| Functional description | Dorsalizing factor. Key developmental protein that dorsalizes early vertebrate embryonic tissues by binding to ventralizing TGF-beta family bone morphogenetic proteins (BMPs) and sequestering them in latent complexes. |
| Sequence | MPSLPAPPAP RLLLGLLLLG SRPAGGTGPE APALPIRSEK EPLPVRGAAG CSFGGKVYAL 60 DETWHPDLGE PFGVMRCVLC ACEAPQWARR GRGPGRVSCK NIKPQCPTLA CRQPRQLPGH 120 CCQTCPQERS NLDPQPAGLV FEYPRDPEHR SYSDRGEPGT GERTRGDGHT DFVALLTGPR 180 TQAVARARVS LLRSSLRFSI SYQRLDRPSR VRFTDPTGNI LFEHPAAPTQ DGLVCGVWRA 240 VPRLSVRLLR AEQLRVALVT PTHPSEEVWG PLIWQGALTA ETFSAILTLE DPLQRGVGGI 300 ALLTLSDTED ALHFLLLFRG LLGGLAHVPL KLQILHQGQL LRELQANASA QEPGFAEVLP 360 SLTDQEMDWL VLGELQMVLE KMGGPELRIS GYITTRQSCD VLQSVLCGAD ALIPVQTGAA 420 GSASFILLGN GSLIYQVQVI GTGSEVVAMT LETKPQRKNQ RTVLCHMAGL QLGGHMAVGV 480 CSGLGARGAH MLLQNELFLN IGTKDFPDGE LRGHVTALCY SGHSAHYDRL PVPLAGALVL 540 PPVRSQAAGH AWLSLDTHCH LHYEVLLAGL GGSEQGTVTA HLLGPPGMPG PQRLLKGFYG 600 SEAQGVVKDL EPVLLRHLTQ GTASLLITTK SNPRGELRGQ VHIASQCEVG GLRLASEGVR 660 MSLAPNGEAA TSPMLPAGPG PEAPVPAKHG SSGRPRDPNT CFFEGQQRPH GARWAPNYDP 720 LCSLCTCQRR TVICDPVVCP PPSCPHPVQA LDQCCPVCPE KQRSRDLPSL PNLEPGEGCY 780 FDGDRSWRAA GTRWHPVVPP FGLIKCAVCT CKGATGEVHC EKVQCPRLAC AQPVRANPTD 840 CCKQCPVGSG THAKLGDPMQ ADGPRGCRFA GQWFPENQSW HPSVPPFGEM SCITCRCGAG 900 VPHCERDDCS PPLSCGSGKE SRCCSHCTAQ RSSETRTLPE LEKEAQRS 948 |
Abbreviation :
CLO : cleft lip only. CPO : cleft palate only.
CLP : cleft lip and palate. CL/P : cleft lip with/without cleft palate.
For humans: CL/P, CLO, CPO, and CLP. For mice: CLO, CLP, and CPO.
| Relation | Gene symbol | Entrez ID | UniProt ID | Cleft type | Developmental stage | Species | Evidence | Details |
|---|---|---|---|---|---|---|---|---|
| 1:1 ortholog | CHRD | 102181631 | A0A452E873 | Capra hircus | Prediction | More>> | ||
| 1:1 ortholog | CHRD | 8646 | Q9H2X0 | Homo sapiens | Prediction | More>> | ||
| 1:1 ortholog | Chrd | 12667 | Q9Z0E2 | CPO | Mus musculus | Publication | More>> | |
| 1:1 ortholog | CHRD | 460892 | A0A2I3TA26 | Pan troglodytes | Prediction | More>> | ||
| 1:1 ortholog | Chrd | 117275 | A0A140TA94 | Rattus norvegicus | Prediction | More>> |
| GO ID | GO Term |
|---|---|
| GO:0005615 | extracellular space |
| GO:0008201 | heparin binding |
| GO:0045545 | syndecan binding |
| GO:0021919 | BMP signaling pathway involved in spinal cord dorsal/ventral patterning |
| GO:0030900 | forebrain development |
| GO:0001702 | gastrulation with mouth forming second |
| GO:0001707 | mesoderm formation |
| GO:0030514 | negative regulation of BMP signaling pathway |
| GO:0030336 | negative regulation of cell migration |
| GO:0045668 | negative regulation of osteoblast differentiation |
| GO:0001649 | osteoblast differentiation |
| GO:0045785 | positive regulation of cell adhesion |
| GO:0002053 | positive regulation of mesenchymal cell proliferation |
| GO:0001501 | skeletal system development |