| Tag | Content |
|---|---|
| Uniprot ID | A0A452E873 |
| Entrez ID | 102181631 |
| Genbank protein ID | |
| Genbank nucleotide ID | XM_018047097.1 |
| Ensembl protein ID | ENSCHIP00000008141 |
| Ensembl nucleotide ID | ENSCHIG00000011375 |
| Gene name | Chordin |
| Gene symbol | CHRD |
| Organism | Capra hircus |
| NCBI taxa ID | 9925 |
| Cleft type | |
| Developmental stage | |
| Data sources | Homology search |
| Reference | |
| Functional description | Dorsalizing factor. Key developmental protein that dorsalizes early vertebrate embryonic tissues by binding to ventralizing TGF-beta family bone morphogenetic proteins (BMPs) and sequestering them in latent complexes. |
| Sequence | MPSLPAPPAP LLLLGLLLLG SRPARGAGPE HPALPIRPEK EPLPIRGAAG CSFGGKVYAL 60 DETWHPDLGE PFGVMRCVLC ACEAPQWGRR ARGAGRVSCK NIKPECPTLA CGQPRQLPGH 120 CCQTCPQEHS SSEKQPTGLA FEYPRDPEHR SYSDRGEPGA EDRGRGDGHT DFVALLTGPR 180 SQAVARARVS LQRSSLRFSI SYRRLDRPTR IRFSDSTGSI LFEHPAAPTQ DGLVCGVWRA 240 VPRLSLRLLR AEQLYVALVT PTHPSGEVWG PLIRHRALAA ETFSAILTLE GPPQPGIGGI 300 ALLTLSDTED SLHFLLLFRG LLESRSGGPA QVPLWLRILH QGKLLRELQA NASAQEPGFA 360 EVLPNLTAQE MDWLVLGELQ MALERASGPG LRISGHIAAR QSCDVLQSVL CGADALIPVQ 420 TGAAGSASLT LLGNGSLIYQ VQVVGTGSEV VAMTLETKPQ RRNQHTVLCH MVGLQPGGHR 480 AVGICPGLGA RGAHMLLQNE LFLNVGTKDF PDGELRGHVA ALPYSGHSAR HDTLPVPLAG 540 ALVLPPVQSQ AAGHAWLSLD THCHLHYEVL LAGLGGSEQG TITAHLLGPP GMPGPRRLLK 600 GFYGPEAQGV VKDLEPELLR HLAQGSASLL ITTKGSPQGE LRGQVHIANQ CEVGGLRLAA 660 AGDKEVQVPG ALEAVAAMVA PLPAVPGPDT PAPARPGGPG RLRDPNTCFF EGQQRPHGAR 720 WAPNYDPLCS LCTCQRRTVI CDPVVCPPPS CPSPVQAPGQ CCPVCPEKQD VKDLPGLPRN 780 RDPGEGCYFD GDRSWRAAGT RWHPVVPPFG LIKCAVCTCK GGTGEVHCEK VQCPRLACAQ 840 PVRANPTDCC KQCPVGSGAH PQLGDPMQAD GPRGCRFAGQ WFPESQSWHP SVPPFGEMSC 900 ITCRCGAGVP HCERDDCSPP LSCGPGKESR CCSHCTPRRR PPETRTVPEL GKEDEGS 957 |
Abbreviation :
CLO : cleft lip only. CPO : cleft palate only.
CLP : cleft lip and palate. CL/P : cleft lip with/without cleft palate.
For humans: CL/P, CLO, CPO, and CLP. For mice: CLO, CLP, and CPO.
| Relation | Gene symbol | Entrez ID | UniProt ID | Cleft type | Developmental stage | Species | Evidence | Details |
|---|---|---|---|---|---|---|---|---|
| 1:1 ortholog | CHRD | 102181631 | A0A452E873 | Capra hircus | Prediction | More>> | ||
| 1:1 ortholog | CHRD | 8646 | Q9H2X0 | Homo sapiens | Prediction | More>> | ||
| 1:1 ortholog | Chrd | 12667 | Q9Z0E2 | CPO | Mus musculus | Publication | More>> | |
| 1:1 ortholog | CHRD | 460892 | A0A2I3TA26 | Pan troglodytes | Prediction | More>> | ||
| 1:1 ortholog | Chrd | 117275 | A0A140TA94 | Rattus norvegicus | Prediction | More>> |
| GO ID | GO Term |
|---|---|
| GO:0005615 | extracellular space |
| GO:0008201 | heparin binding |
| GO:0045545 | syndecan binding |
| GO:0021919 | BMP signaling pathway involved in spinal cord dorsal/ventral patterning |
| GO:0030900 | forebrain development |
| GO:0001702 | gastrulation with mouth forming second |
| GO:0001707 | mesoderm formation |
| GO:0030514 | negative regulation of BMP signaling pathway |
| GO:0030336 | negative regulation of cell migration |
| GO:0045668 | negative regulation of osteoblast differentiation |
| GO:0001649 | osteoblast differentiation |
| GO:0045785 | positive regulation of cell adhesion |
| GO:0002053 | positive regulation of mesenchymal cell proliferation |
| GO:0001501 | skeletal system development |