| Tag | Content |
|---|---|
| Uniprot ID | A0A2I3TA26; A0A2J8M5N3; |
| Entrez ID | 460892 |
| Genbank protein ID | |
| Genbank nucleotide ID | XM_016942434.1 |
| Ensembl protein ID | ENSPTRP00000086110 |
| Ensembl nucleotide ID | ENSPTRG00000015695 |
| Gene name | Chordin |
| Gene symbol | CHRD |
| Organism | Pan troglodytes |
| NCBI taxa ID | 9598 |
| Cleft type | |
| Developmental stage | |
| Data sources | Homology search |
| Reference | |
| Functional description | Dorsalizing factor. Key developmental protein that dorsalizes early vertebrate embryonic tissues by binding to ventralizing TGF-beta family bone morphogenetic proteins (BMPs) and sequestering them in latent complexes. |
| Sequence | MPSLPAPPAP LLLLGLLLLG SRPARGAGPE PPVLPIRSEK EPLPVRGAAG CSFGGKVYAL 60 DETWHPDLGE PFGVMRCVLC ACEAPQWGRR TRGPGRVSCK NIKPECPTPA CGQPRQLPGH 120 CCQTCPQERS SSERQPSGLS FEYPRDPEHR SYSDRGEPGA EERARGDGHT DFVALLTGPR 180 SQAVARARVS LLRSSLRFSI SYRRLDRPTR VRFSDSNGSV LFEHPAAPTQ DGLVCGVWRA 240 VPRLSLRLLR AEQLHVALVT LTHPSGEVWG PLIRHRALAA ETFSAILTLE GPPQQGVGGI 300 TLLTLSDTED SLHFLLLFRG LLEPRSGGLT QVPLRLQILH QGQLLRELQA NVSAQEPGFA 360 EVLPNLTVQE MDWLVLGELQ MALELAGRPG LRISGHIAAR KSCDVLQSVL CGADALIPVQ 420 TGAAGSASLT LLGNGSLIYQ VQVVGTSSEV VAMTLETKPQ RRDQRTVLCH MAGLQPGGHT 480 AVGICPGLGA RGAHMLLQNE LFLNVGTKDF PDGELRGHVA ALPYCGHSAR HDTLPVPLAG 540 ALVLPPVKSQ AAGHAWLSLD THCHLHYEVL LAGLGGSEQG TVTAHLLGPP GTPGPRRLLK 600 GFYGSEAQGV VKDLEPELLR HLAKGMASLL ITTKGSPRGE LRGQVHIANQ CEVGGLRLEA 660 AGAEGVRALG APDTAAAAPP VVRGLPALAP AKPGGPGRPR DPNTCFFEGQ QRPHGARWAP 720 NYDPLCSLCT CQRRTVICDP VVCPPPSCPH PVQAPDQCCP VCPEKQDVRD LPGLPRSRDP 780 GEGCYFDGDR SWRAAGTRWH PVVPPFGLIK CAVCTCKGGT GEVHCEKVQC PRLACAQPVR 840 VNPTDCCKQC PVGSGAHPQL GDPMQADGPR GCRFAGQWFP ESQSWHPSVP PFGEMSCITC 900 RCGAGVPHCE RDDCSLPLSC GSGKESRCCS RCTAHRRPAP ETRTDPELEK EAEGS 955 |
Abbreviation :
CLO : cleft lip only. CPO : cleft palate only.
CLP : cleft lip and palate. CL/P : cleft lip with/without cleft palate.
For humans: CL/P, CLO, CPO, and CLP. For mice: CLO, CLP, and CPO.
| Relation | Gene symbol | Entrez ID | UniProt ID | Cleft type | Developmental stage | Species | Evidence | Details |
|---|---|---|---|---|---|---|---|---|
| 1:1 ortholog | CHRD | 102181631 | A0A452E873 | Capra hircus | Prediction | More>> | ||
| 1:1 ortholog | CHRD | 8646 | Q9H2X0 | Homo sapiens | Prediction | More>> | ||
| 1:1 ortholog | Chrd | 12667 | Q9Z0E2 | CPO | Mus musculus | Publication | More>> | |
| 1:1 ortholog | CHRD | 460892 | A0A2I3TA26 | Pan troglodytes | Prediction | More>> | ||
| 1:1 ortholog | Chrd | 117275 | A0A140TA94 | Rattus norvegicus | Prediction | More>> |
| GO ID | GO Term |
|---|---|
| GO:0005615 | extracellular space |
| GO:0008201 | heparin binding |
| GO:0045545 | syndecan binding |
| GO:0021919 | BMP signaling pathway involved in spinal cord dorsal/ventral patterning |
| GO:0030900 | forebrain development |
| GO:0001702 | gastrulation with mouth forming second |
| GO:0001707 | mesoderm formation |
| GO:0030514 | negative regulation of BMP signaling pathway |
| GO:0030336 | negative regulation of cell migration |
| GO:0045668 | negative regulation of osteoblast differentiation |
| GO:0001649 | osteoblast differentiation |
| GO:0045785 | positive regulation of cell adhesion |
| GO:0002053 | positive regulation of mesenchymal cell proliferation |
| GO:0001501 | skeletal system development |