| Tag | Content |
|---|---|
| Uniprot ID | Q9Z0E2 |
| Entrez ID | 12667 |
| Genbank protein ID | AAD19895.1; AAC68867.1; |
| Genbank nucleotide ID | NM_001278041.1; NM_009893.2; |
| Ensembl protein ID | ENSMUSP00000007171 |
| Ensembl nucleotide ID | ENSMUSG00000006958 |
| Gene name | Chordin |
| Gene symbol | Chrd |
| Organism | Mus musculus |
| NCBI taxa ID | 10090 |
| Cleft type | CPO |
| Developmental stage | |
| Data sources | Manually collected |
| Reference | 24949938; 19247433; |
| Functional description | Dorsalizing factor. Key developmental protein that dorsalizes early vertebrate embryonic tissues by binding to ventralizing TGF-beta family bone morphogenetic proteins (BMPs) and sequestering them in latent complexes. |
| Sequence | MPSLPAPPAP RLLLGLLLLG SRPASGTGPE PPALPIRSEK EPLPVRGAAG CSFGGKVYAL 60 DETWHPDLGE PFGVMRCVLC ACEAPQWARR GRGPGRVSCK NIKPQCPTLA CRQPRQLPGH 120 CCQTCPQERS NLDPQPAGLV FEYPRDPEHR SYSDRGEPGV GERTRADGHT DFVALLTGPR 180 SQAVARARVS LLRSSLRFSV SYQRLDRPSR VRFTDPTGNI LFEHPATPTQ DGLVCGVWRA 240 VPRLSVRLLR AEQLRVALVT STHPSGEVWG PLIWQGALAA ETFSAILTLE DPLQRGVGGI 300 ALLTLSDTED SLHFLLLFRG LLGGLAQAPL KLQILHQGQL LRELQANTSA QEPGFAEVLP 360 SLTDQEMDWL ELGELQMVLE KAGGPELRIS GYITTRQSCD VLQSVLCGAD ALIPVQTGAA 420 GSASFILLGN GSLIYQVQVV GTGSEVVAMT LETKPQRKNQ RTVLCHMAGL QPGGHMAVGM 480 CSGLGARGAH MLLQNELFLN VGTKDFPDGE LRGHVTALCY SGHSARYDRL PVPLAGALVL 540 PPVRSQAAGH AWLSLDTHCH LHYEVLLAGL GGSEQGTVTA HLLGPPGMPG PQRLLKGFYG 600 SEAQGVVKDL EPVLLRHLAQ GTASLLITTK SSPRGELRGQ VHIASQCEAG GLRLASEGVQ 660 MPLAPNGEAA TSPMLPAGPG PEAPVPAKHG SPGRPRDPNT CFFEGQQRPH GARWAPNYDP 720 LCSLCICQRR TVICDPVVCP PPSCPHPVQA LDQCCPVCPE KQRSRDLPSL PNLEPGEGCY 780 FDGDRSWRAA GTRWHPVVPP FGLIKCAVCT CKGATGEVHC EKVQCPRLAC AQPVRANPTD 840 CCKQCPVGSG TNAKLGDPMQ ADGPRGCRFA GQWFPENQSW HPSVPPFGEM SCITCRCGAG 900 VPHCERDDCS PPLSCGSGKE SRCCSHCTAQ RSSETRTLPE LEKEAEHS 948 |
Abbreviation :
CLO : cleft lip only. CPO : cleft palate only.
CLP : cleft lip and palate. CL/P : cleft lip with/without cleft palate.
For humans: CL/P, CLO, CPO, and CLP. For mice: CLO, CLP, and CPO.
| Relation | Gene symbol | Entrez ID | UniProt ID | Cleft type | Developmental stage | Species | Evidence | Details |
|---|---|---|---|---|---|---|---|---|
| 1:1 ortholog | CHRD | 102181631 | A0A452E873 | Capra hircus | Prediction | More>> | ||
| 1:1 ortholog | CHRD | 8646 | Q9H2X0 | Homo sapiens | Prediction | More>> | ||
| 1:1 ortholog | Chrd | 12667 | Q9Z0E2 | CPO | Mus musculus | Publication | More>> | |
| 1:1 ortholog | CHRD | 460892 | A0A2I3TA26 | Pan troglodytes | Prediction | More>> | ||
| 1:1 ortholog | Chrd | 117275 | A0A140TA94 | Rattus norvegicus | Prediction | More>> |
| GO ID | GO Term | Evidence |
|---|---|---|
| GO:0008201 | heparin binding | IDA |
| GO:0045545 | syndecan binding | IDA |
| GO ID | GO Term | Evidence |
|---|---|---|
| GO:0001501 | skeletal system development | IMP |
| GO:0001649 | osteoblast differentiation | IDA |
| GO:0001702 | gastrulation with mouth forming second | IMP |
| GO:0001707 | mesoderm formation | IMP |
| GO:0002053 | positive regulation of mesenchymal cell proliferation | ISO |
| GO:0007389 | pattern specification process | IMP |
| GO:0007417 | central nervous system development | IMP |
| GO:0009953 | dorsal/ventral pattern formation | IMP |
| GO:0021919 | BMP signaling pathway involved in spinal cord dorsal/ventral patterning | ISO |
| GO:0030336 | negative regulation of cell migration | ISO |
| GO:0030514 | negative regulation of BMP signaling pathway | ISO |
| GO:0030514 | negative regulation of BMP signaling pathway | IDA |
| GO:0030900 | forebrain development | IMP |
| GO:0045668 | negative regulation of osteoblast differentiation | ISO |
| GO:0045668 | negative regulation of osteoblast differentiation | IDA |
| GO:0045785 | positive regulation of cell adhesion | ISO |
| GO ID | GO Term | Evidence |
|---|---|---|
| GO:0005615 | extracellular space | IDA |
| Reactome ID | Reactome Term | Evidence |
|---|