| Tag | Content |
|---|---|
| Uniprot ID | A0A142I1Y1 |
| Entrez ID | 102188850 |
| Genbank protein ID | AMR36588.1 |
| Genbank nucleotide ID | XM_005683084.3; XM_018050209.1; XM_005683082.3; |
| Ensembl protein ID | ENSCHIP00000033180 |
| Ensembl nucleotide ID | ENSCHIG00000026836 |
| Gene name | Multifunctional fusion protein |
| Gene symbol | FGF1 |
| Organism | Capra hircus |
| NCBI taxa ID | 9925 |
| Cleft type | |
| Developmental stage | |
| Data sources | Homology search |
| Reference | |
| Functional description | Plays an important role in the regulation of cell survival, cell division, angiogenesis, cell differentiation and cell migration. Functions as potent mitogen in vitro. Acts as a ligand for FGFR1 and integrins. Binds to FGFR1 in the presence of heparin leading to FGFR1 dimerization and activation via sequential autophosphorylation on tyrosine residues which act as docking sites for interacting proteins, leading to the activation of several signaling cascades. Binds to integrins. Its binding to integrins and subsequent ternary complex formation with integrins and FGFR1 are essential for FGF1 signaling. |
| Sequence | MAEGETTTFR ALTEKFNLPL GNYKKPKLLY CSNGGYFLRI LPDGKVDGTK DRSDQHIQLQ 60 LYAESIGEVY IKSTETGQFL AMDTNGLLYG SQTPSEECLF LERLEENHYN TYISKKHAEK 120 NWFIGLKKNG SSKLGPRTHF GQKAILFLPL PVSSD 155 |
Abbreviation :
CLO : cleft lip only. CPO : cleft palate only.
CLP : cleft lip and palate. CL/P : cleft lip with/without cleft palate.
For humans: CL/P, CLO, CPO, and CLP. For mice: CLO, CLP, and CPO.
| Relation | Gene symbol | Entrez ID | UniProt ID | Cleft type | Developmental stage | Species | Evidence | Details |
|---|---|---|---|---|---|---|---|---|
| 1:1 ortholog | FGF1 | 281160 | P03968 | Bos taurus | Prediction | More>> | ||
| 1:1 ortholog | FGF1 | 607724 | J9NTP4 | Canis lupus familiaris | Prediction | More>> | ||
| 1:1 ortholog | FGF1 | 102188850 | A0A142I1Y1 | Capra hircus | Prediction | More>> | ||
| 1:1 ortholog | FGF1 | 100033960 | F6WDN0 | Equus caballus | Prediction | More>> | ||
| 1:1 ortholog | FGF1 | 2246 | P05230 | CPO,CL/P | Homo sapiens | Publication | More>> | |
| 1:1 ortholog | Fgf1 | 14164 | P61148 | E14.5 | Mus musculus | Prediction | More>> | |
| 1:1 ortholog | FGF1 | 462158 | A0A2J8NIY5 | Pan troglodytes | Prediction | More>> | ||
| 1:1 ortholog | FGF1 | 397497 | F1RM38 | Sus scrofa | Prediction | More>> | ||
| 1:1 ortholog | FGF1 | 100328898 | B7NZB1 | Oryctolagus cuniculus | Prediction | More>> | ||
| 1:1 ortholog | Fgf1 | 25317 | P61149 | Rattus norvegicus | Prediction | More>> |
| GO ID | GO Term |
|---|---|
| GO:0005938 | cell cortex |
| GO:0005829 | cytosol |
| GO:0031012 | extracellular matrix |
| GO:0005615 | extracellular space |
| GO:0005654 | nucleoplasm |
| GO:0005104 | fibroblast growth factor receptor binding |
| GO:0008083 | growth factor activity |
| GO:0008201 | heparin binding |
| GO:0005178 | integrin binding |
| GO:0044548 | S100 protein binding |
| GO:0000187 | activation of MAPK activity |
| GO:0032148 | activation of protein kinase B activity |
| GO:0001525 | angiogenesis |
| GO:0060681 | branch elongation involved in ureteric bud branching |
| GO:0030154 | cell differentiation |
| GO:0034605 | cellular response to heat |
| GO:0008543 | fibroblast growth factor receptor signaling pathway |
| GO:0030324 | lung development |
| GO:0001759 | organ induction |
| GO:0051781 | positive regulation of cell division |
| GO:0045542 | positive regulation of cholesterol biosynthetic process |
| GO:0010595 | positive regulation of endothelial cell migration |
| GO:0050679 | positive regulation of epithelial cell proliferation |
| GO:1903672 | positive regulation of sprouting angiogenesis |
| GO:0045944 | positive regulation of transcription by RNA polymerase II |
| GO:2000544 | regulation of endothelial cell chemotaxis to fibroblast growth factor |
| GO:1901509 | regulation of endothelial tube morphogenesis |
| GO:0042060 | wound healing |
| PROSITE ID | PROSITE Term |
|---|---|
| PS00247 | HBGF_FGF |
| Pfam ID | Pfam Term |
|---|---|
| PF00167 | FGF |