Gene: Fgf1

Basic information

Tag Content
Uniprot ID P61148; P10935;
Entrez ID 14164
Genbank protein ID AAA37618.1; AAC52969.1; AAH37601.1; AAC52907.1;
Genbank nucleotide ID XM_011246842.2; XM_011246843.2; XM_006525645.3; XM_017317830.1; NM_010197.3; XM_006525644.3; XM_006525648.3; XM_006525649.1; XM_006525647.3;
Ensembl protein ID ENSMUSP00000045710; ENSMUSP00000157968; ENSMUSP00000111245;
Ensembl nucleotide ID ENSMUSG00000036585
Gene name Fibroblast growth factor 1
Gene symbol Fgf1
Organism Mus musculus
NCBI taxa ID 10090
Cleft type
Developmental stage E14.5
Data sources Homology search
Reference
Functional description Plays an important role in the regulation of cell survival, cell division, angiogenesis, cell differentiation and cell migration. Functions as potent mitogen in vitro. Acts as a ligand for FGFR1 and integrins. Binds to FGFR1 in the presence of heparin leading to FGFR1 dimerization and activation via sequential autophosphorylation on tyrosine residues which act as docking sites for interacting proteins, leading to the activation of several signaling cascades. Binds to integrin ITGAV:ITGB3. Its binding to integrin, subsequent ternary complex formation with integrin and FGFR1, and the recruitment of PTPN11 to the complex are essential for FGF1 signaling. Induces the phosphorylation and activation of FGFR1, FRS2, MAPK3/ERK1, MAPK1/ERK2 and AKT1. Can induce angiogenesis.
Sequence
MAEGEITTFA ALTERFNLPL GNYKKPKLLY CSNGGHFLRI LPDGTVDGTR DRSDQHIQLQ 60
LSAESAGEVY IKGTETGQYL AMDTEGLLYG SQTPNEECLF LERLEENHYN TYTSKKHAEK 120
NWFVGLKKNG SCKRGPRTHY GQKAILFLPL PVSSD 155

Abbreviation :
CLO : cleft lip only. CPO : cleft palate only. CLP : cleft lip and palate. CL/P : cleft lip with/without cleft palate.
For humans: CL/P, CLO, CPO, and CLP. For mice: CLO, CLP, and CPO.

Gene expression information

Gene expression during embryonic days (E11.5~E18.5) ~ adult days (Ps) in the lip and palate tissues. (X-axis: days, Y-axis: tissues)

loading...

Protein structural annotations

3D structure in PDB database

There is no related protein structure for this gene.

Protein disorder information

Orthologous information

Relation Gene symbol Entrez ID UniProt ID Cleft type Developmental stage Species Evidence Details
1:1 orthologFGF1281160P03968Bos taurusPredictionMore>>
1:1 orthologFGF1607724J9NTP4Canis lupus familiarisPredictionMore>>
1:1 orthologFGF1102188850A0A142I1Y1Capra hircusPredictionMore>>
1:1 orthologFGF1100033960F6WDN0Equus caballusPredictionMore>>
1:1 orthologFGF12246P05230CPO,CL/PHomo sapiensPublicationMore>>
1:1 orthologFgf114164P61148E14.5Mus musculusPredictionMore>>
1:1 orthologFGF1462158A0A2J8NIY5Pan troglodytesPredictionMore>>
1:1 orthologFGF1397497F1RM38Sus scrofaPredictionMore>>
1:1 orthologFGF1100328898B7NZB1Oryctolagus cuniculusPredictionMore>>
1:1 orthologFgf125317P61149Rattus norvegicusPredictionMore>>

Identified variants/mutations related to cleft phenotype

Gene symbol Significant Variants/SNPS Methods PubMed ID
FGF1rs34010C>AT-ARMS-PCR24613087
FGF1rs34010G>T (decrease risk)Genotyping21462296

Gene Ontology (GO)/biological pathways

GO:Molecular Function

GO ID GO Term Evidence
GO:0005104 fibroblast growth factor receptor bindingISO
GO:0005104 fibroblast growth factor receptor bindingISS
GO:0005178 integrin bindingISS
GO:0005178 integrin bindingISO
GO:0005515 protein bindingIPI
GO:0008083 growth factor activityISS
GO:0008083 growth factor activityISO
GO:0008201 heparin bindingISS
GO:0008201 heparin bindingISO
GO:0030544 Hsp70 protein bindingISO
GO:0044548 S100 protein bindingISS
GO:0044548 S100 protein bindingISO

GO:Biological Process

GO ID GO Term Evidence
GO:0000187 activation of MAPK activityISS
GO:0000187 activation of MAPK activityISO
GO:0001525 angiogenesisIEA
GO:0001759 organ inductionIDA
GO:0001934 positive regulation of protein phosphorylationIDA
GO:0008283 cell population proliferationISO
GO:0008284 positive regulation of cell population proliferationISO
GO:0008284 positive regulation of cell population proliferationISS
GO:0008543 fibroblast growth factor receptor signaling pathwayISO
GO:0008543 fibroblast growth factor receptor signaling pathwayISS
GO:0010595 positive regulation of endothelial cell migrationISS
GO:0010595 positive regulation of endothelial cell migrationISO
GO:0030324 lung developmentIDA
GO:0030335 positive regulation of cell migrationISS
GO:0030335 positive regulation of cell migrationISO
GO:0032148 activation of protein kinase B activityISS
GO:0032148 activation of protein kinase B activityISO
GO:0034605 cellular response to heatISS
GO:0034605 cellular response to heatISO
GO:0042060 wound healingISO
GO:0043406 positive regulation of MAP kinase activityISO
GO:0045542 positive regulation of cholesterol biosynthetic processISS
GO:0045542 positive regulation of cholesterol biosynthetic processISO
GO:0045766 positive regulation of angiogenesisISS
GO:0045766 positive regulation of angiogenesisISO
GO:0045893 positive regulation of transcription, DNA-templatedTAS
GO:0045944 positive regulation of transcription by RNA polymerase IIISO
GO:0045944 positive regulation of transcription by RNA polymerase IIIGI
GO:0050679 positive regulation of epithelial cell proliferationIDA
GO:0051781 positive regulation of cell divisionISS
GO:0051781 positive regulation of cell divisionISO
GO:0060038 cardiac muscle cell proliferationTAS
GO:0060681 branch elongation involved in ureteric bud branchingISS
GO:0060681 branch elongation involved in ureteric bud branchingISO
GO:0060979 vasculogenesis involved in coronary vascular morphogenesisTAS
GO:0072163 mesonephric epithelium developmentISS
GO:0072163 mesonephric epithelium developmentISO
GO:1901509 regulation of endothelial tube morphogenesisISS
GO:1901509 regulation of endothelial tube morphogenesisISO
GO:1902533 positive regulation of intracellular signal transductionISS
GO:1902533 positive regulation of intracellular signal transductionISO
GO:1903672 positive regulation of sprouting angiogenesisISS
GO:1903672 positive regulation of sprouting angiogenesisISO
GO:2000347 positive regulation of hepatocyte proliferationIEA
GO:2000544 regulation of endothelial cell chemotaxis to fibroblast growth factorISO

GO:Cellular Component

GO ID GO Term Evidence
GO:0005576 extracellular regionISS
GO:0005576 extracellular regionISO
GO:0005576 extracellular regionIDA
GO:0005615 extracellular spaceISO
GO:0005615 extracellular spaceIDA
GO:0005634 nucleusISO
GO:0005654 nucleoplasmISO
GO:0005730 nucleolusISO
GO:0005737 cytoplasmISO
GO:0005829 cytosolISS
GO:0005829 cytosolISO
GO:0005938 cell cortexIEA
GO:0031012 extracellular matrixIDA

Reactome Pathway

Reactome ID Reactome Term Evidence
R-MMU-109704 PI3K CascadeIEA
R-MMU-112399 IRS-mediated signallingIEA
R-MMU-1257604 PIP3 activates AKT signalingIEA
R-MMU-1280215 Cytokine Signaling in Immune systemIEA
R-MMU-162582 Signal TransductionIEA
R-MMU-168256 Immune SystemIEA
R-MMU-190236 Signaling by FGFRIEA
R-MMU-190239 FGFR3 ligand binding and activationIEA
R-MMU-190241 FGFR2 ligand binding and activationIEA
R-MMU-190242 FGFR1 ligand binding and activationIEA
R-MMU-190322 FGFR4 ligand binding and activationIEA
R-MMU-190370 FGFR1b ligand binding and activationIEA
R-MMU-190371 FGFR3b ligand binding and activationIEA
R-MMU-190372 FGFR3c ligand binding and activationIEA
R-MMU-190373 FGFR1c ligand binding and activationIEA
R-MMU-190375 FGFR2c ligand binding and activationIEA
R-MMU-190377 FGFR2b ligand binding and activationIEA
R-MMU-199418 Negative regulation of the PI3K/AKT networkIEA
R-MMU-2404192 Signaling by Type 1 Insulin-like Growth Factor 1 Receptor (IGF1R)IEA
R-MMU-2428924 IGF1R signaling cascadeIEA
R-MMU-2428928 IRS-related events triggered by IGF1RIEA
R-MMU-5654219 Phospholipase C-mediated cascade: FGFR1IEA
R-MMU-5654221 Phospholipase C-mediated cascade; FGFR2IEA
R-MMU-5654227 Phospholipase C-mediated cascade; FGFR3IEA
R-MMU-5654228 Phospholipase C-mediated cascade; FGFR4IEA
R-MMU-5654687 Downstream signaling of activated FGFR1IEA
R-MMU-5654688 SHC-mediated cascade:FGFR1IEA
R-MMU-5654689 PI-3K cascade:FGFR1IEA
R-MMU-5654693 FRS-mediated FGFR1 signalingIEA
R-MMU-5654695 PI-3K cascade:FGFR2IEA
R-MMU-5654696 Downstream signaling of activated FGFR2IEA
R-MMU-5654699 SHC-mediated cascade:FGFR2IEA
R-MMU-5654700 FRS-mediated FGFR2 signalingIEA
R-MMU-5654704 SHC-mediated cascade:FGFR3IEA
R-MMU-5654706 FRS-mediated FGFR3 signalingIEA
R-MMU-5654708 Downstream signaling of activated FGFR3IEA
R-MMU-5654710 PI-3K cascade:FGFR3IEA
R-MMU-5654712 FRS-mediated FGFR4 signalingIEA
R-MMU-5654716 Downstream signaling of activated FGFR4IEA
R-MMU-5654719 SHC-mediated cascade:FGFR4IEA
R-MMU-5654720 PI-3K cascade:FGFR4IEA
R-MMU-5654726 Negative regulation of FGFR1 signalingIEA
R-MMU-5654727 Negative regulation of FGFR2 signalingIEA
R-MMU-5654732 Negative regulation of FGFR3 signalingIEA
R-MMU-5654733 Negative regulation of FGFR4 signalingIEA
R-MMU-5654736 Signaling by FGFR1IEA
R-MMU-5654738 Signaling by FGFR2IEA
R-MMU-5654741 Signaling by FGFR3IEA
R-MMU-5654743 Signaling by FGFR4IEA
R-MMU-5673001 RAF/MAP kinase cascadeIEA
R-MMU-5683057 MAPK family signaling cascadesIEA
R-MMU-5684996 MAPK1/MAPK3 signalingIEA
R-MMU-6811558 PI5P, PP2A and IER3 Regulate PI3K/AKT SignalingIEA
R-MMU-74751 Insulin receptor signalling cascadeIEA
R-MMU-74752 Signaling by Insulin receptorIEA
R-MMU-9006925 Intracellular signaling by second messengersIEA
R-MMU-9006934 Signaling by Receptor Tyrosine KinasesIEA
R-MMU-9607240 FLT3 SignalingIEA

Functional annotations

Keywords

Keyword ID Keyword Term
KW-0007 Acetylation
KW-0037 Angiogenesis
KW-0963 Cytoplasm
KW-0217 Developmental protein
KW-0221 Differentiation
KW-0339 Growth factor
KW-0358 Heparin-binding
KW-0497 Mitogen
KW-0539 Nucleus
KW-0597 Phosphoprotein
KW-1185 Reference proteome
KW-0964 Secreted

Interpro

InterPro ID InterPro Term
IPR028210 FGF1
IPR002209 Fibroblast_GF_fam
IPR008996 IL1/FGF

PROSITE

PROSITE ID PROSITE Term
PS00247 HBGF_FGF

Pfam

Pfam ID Pfam Term
PF00167 FGF

Protein-protein interaction

Protein-miRNA interaction