Gene: FGF1

Basic information

Tag Content
Uniprot ID A0A2J8NIY5; H2QRP4;
Entrez ID 462158
Genbank protein ID
Genbank nucleotide ID XM_016953980.1; XM_016953979.1; XM_009449854.2; XM_001153487.4; XM_001153676.4; XM_001153608.4;
Ensembl protein ID ENSPTRP00000029676
Ensembl nucleotide ID ENSPTRG00000017361
Gene name Multifunctional fusion protein
Gene symbol FGF1
Organism Pan troglodytes
NCBI taxa ID 9598
Cleft type
Developmental stage
Data sources Homology search
Reference
Functional description Plays an important role in the regulation of cell survival, cell division, angiogenesis, cell differentiation and cell migration. Functions as potent mitogen in vitro. Acts as a ligand for FGFR1 and integrins. Binds to FGFR1 in the presence of heparin leading to FGFR1 dimerization and activation via sequential autophosphorylation on tyrosine residues which act as docking sites for interacting proteins, leading to the activation of several signaling cascades. Binds to integrins. Its binding to integrins and subsequent ternary complex formation with integrins and FGFR1 are essential for FGF1 signaling.
Sequence
MAEGEITTFT ALTEKFNLPP GNYKKPKLLY CSNGGHFLRI LPDGTVDGTR DRSDQHIQLQ 60
LSAESVGEVY IKSTETGQYL AMDTDGLLYG SQTPNEECLF LERLEENHYN TYISKKHAEK 120
NWFVGLKKNG SCKRGPRTHY GQKAILFLPL PVSSD 155

Abbreviation :
CLO : cleft lip only. CPO : cleft palate only. CLP : cleft lip and palate. CL/P : cleft lip with/without cleft palate.
For humans: CL/P, CLO, CPO, and CLP. For mice: CLO, CLP, and CPO.

Protein disorder information

Orthologous information

Relation Gene symbol Entrez ID UniProt ID Cleft type Developmental stage Species Evidence Details
1:1 orthologFGF1281160P03968Bos taurusPredictionMore>>
1:1 orthologFGF1607724J9NTP4Canis lupus familiarisPredictionMore>>
1:1 orthologFGF1102188850A0A142I1Y1Capra hircusPredictionMore>>
1:1 orthologFGF1100033960F6WDN0Equus caballusPredictionMore>>
1:1 orthologFGF12246P05230CPO,CL/PHomo sapiensPublicationMore>>
1:1 orthologFgf114164P61148E14.5Mus musculusPredictionMore>>
1:1 orthologFGF1462158A0A2J8NIY5Pan troglodytesPredictionMore>>
1:1 orthologFGF1397497F1RM38Sus scrofaPredictionMore>>
1:1 orthologFGF1100328898B7NZB1Oryctolagus cuniculusPredictionMore>>
1:1 orthologFgf125317P61149Rattus norvegicusPredictionMore>>

Gene ontology

GO ID GO Term
GO:0005938 cell cortex
GO:0005829 cytosol
GO:0031012 extracellular matrix
GO:0005615 extracellular space
GO:0005654 nucleoplasm
GO:0005104 fibroblast growth factor receptor binding
GO:0008083 growth factor activity
GO:0008201 heparin binding
GO:0005178 integrin binding
GO:0044548 S100 protein binding
GO:0000187 activation of MAPK activity
GO:0032148 activation of protein kinase B activity
GO:0001525 angiogenesis
GO:0060681 branch elongation involved in ureteric bud branching
GO:0030154 cell differentiation
GO:0034605 cellular response to heat
GO:0008543 fibroblast growth factor receptor signaling pathway
GO:0030324 lung development
GO:0001759 organ induction
GO:0051781 positive regulation of cell division
GO:0045542 positive regulation of cholesterol biosynthetic process
GO:0010595 positive regulation of endothelial cell migration
GO:0050679 positive regulation of epithelial cell proliferation
GO:1903672 positive regulation of sprouting angiogenesis
GO:0045944 positive regulation of transcription by RNA polymerase II
GO:2000544 regulation of endothelial cell chemotaxis to fibroblast growth factor
GO:1901509 regulation of endothelial tube morphogenesis
GO:0042060 wound healing

Functional annotations

Keywords

Keyword ID Keyword Term
KW-0037 Angiogenesis
KW-0963 Cytoplasm
KW-0217 Developmental protein
KW-0221 Differentiation
KW-0339 Growth factor
KW-0358 Heparin-binding
KW-0497 Mitogen
KW-0539 Nucleus
KW-1185 Reference proteome
KW-0964 Secreted

Interpro

InterPro ID InterPro Term
IPR028210 FGF1
IPR002209 Fibroblast_GF_fam
IPR008996 IL1/FGF

PROSITE

PROSITE ID PROSITE Term
PS00247 HBGF_FGF

Pfam

Pfam ID Pfam Term
PF00167 FGF