| Tag | Content |
|---|---|
| Uniprot ID | P61149; P10935; |
| Entrez ID | 25317 |
| Genbank protein ID | CAA32448.1 |
| Genbank nucleotide ID | XM_006254651.3; NM_012846.1; XM_006254652.3; XM_006254650.3; |
| Ensembl protein ID | ENSRNOP00000018577; ENSRNOP00000070685; |
| Ensembl nucleotide ID | ENSRNOG00000013867 |
| Gene name | Fibroblast growth factor 1 |
| Gene symbol | Fgf1 |
| Organism | Rattus norvegicus |
| NCBI taxa ID | 10116 |
| Cleft type | |
| Developmental stage | |
| Data sources | Homology search |
| Reference | |
| Functional description | Plays an important role in the regulation of cell survival, cell division, angiogenesis, cell differentiation and cell migration. Functions as potent mitogen in vitro. Acts as a ligand for FGFR1 and integrins. Binds to FGFR1 in the presence of heparin leading to FGFR1 dimerization and activation via sequential autophosphorylation on tyrosine residues which act as docking sites for interacting proteins, leading to the activation of several signaling cascades. Binds to integrin ITGAV:ITGB3. Its binding to integrin, subsequent ternary complex formation with integrin and FGFR1, and the recruitment of PTPN11 to the complex are essential for FGF1 signaling. Induces the phosphorylation and activation of FGFR1, FRS2, MAPK3/ERK1, MAPK1/ERK2 and AKT1. Can induce angiogenesis. |
| Sequence | MAEGEITTFA ALTERFNLPL GNYKKPKLLY CSNGGHFLRI LPDGTVDGTR DRSDQHIQLQ 60 LSAESAGEVY IKGTETGQYL AMDTEGLLYG SQTPNEECLF LERLEENHYN TYTSKKHAEK 120 NWFVGLKKNG SCKRGPRTHY GQKAILFLPL PVSSD 155 |
Abbreviation :
CLO : cleft lip only. CPO : cleft palate only.
CLP : cleft lip and palate. CL/P : cleft lip with/without cleft palate.
For humans: CL/P, CLO, CPO, and CLP. For mice: CLO, CLP, and CPO.
| Relation | Gene symbol | Entrez ID | UniProt ID | Cleft type | Developmental stage | Species | Evidence | Details |
|---|---|---|---|---|---|---|---|---|
| 1:1 ortholog | FGF1 | 281160 | P03968 | Bos taurus | Prediction | More>> | ||
| 1:1 ortholog | FGF1 | 607724 | J9NTP4 | Canis lupus familiaris | Prediction | More>> | ||
| 1:1 ortholog | FGF1 | 102188850 | A0A142I1Y1 | Capra hircus | Prediction | More>> | ||
| 1:1 ortholog | FGF1 | 100033960 | F6WDN0 | Equus caballus | Prediction | More>> | ||
| 1:1 ortholog | FGF1 | 2246 | P05230 | CPO,CL/P | Homo sapiens | Publication | More>> | |
| 1:1 ortholog | Fgf1 | 14164 | P61148 | E14.5 | Mus musculus | Prediction | More>> | |
| 1:1 ortholog | FGF1 | 462158 | A0A2J8NIY5 | Pan troglodytes | Prediction | More>> | ||
| 1:1 ortholog | FGF1 | 397497 | F1RM38 | Sus scrofa | Prediction | More>> | ||
| 1:1 ortholog | FGF1 | 100328898 | B7NZB1 | Oryctolagus cuniculus | Prediction | More>> | ||
| 1:1 ortholog | Fgf1 | 25317 | P61149 | Rattus norvegicus | Prediction | More>> |
| GO ID | GO Term |
|---|---|
| GO:0005938 | cell cortex |
| GO:0005737 | cytoplasm |
| GO:0005829 | cytosol |
| GO:0031012 | extracellular matrix |
| GO:0005576 | extracellular region |
| GO:0005615 | extracellular space |
| GO:0005730 | nucleolus |
| GO:0005654 | nucleoplasm |
| GO:0005634 | nucleus |
| GO:0005104 | fibroblast growth factor receptor binding |
| GO:0008083 | growth factor activity |
| GO:0008201 | heparin binding |
| GO:0030544 | Hsp70 protein binding |
| GO:0005178 | integrin binding |
| GO:0044548 | S100 protein binding |
| GO:0000187 | activation of MAPK activity |
| GO:0032148 | activation of protein kinase B activity |
| GO:0001525 | angiogenesis |
| GO:0060681 | branch elongation involved in ureteric bud branching |
| GO:0030154 | cell differentiation |
| GO:0034605 | cellular response to heat |
| GO:0008543 | fibroblast growth factor receptor signaling pathway |
| GO:0030324 | lung development |
| GO:0072163 | mesonephric epithelium development |
| GO:0001759 | organ induction |
| GO:0045766 | positive regulation of angiogenesis |
| GO:0051781 | positive regulation of cell division |
| GO:0030335 | positive regulation of cell migration |
| GO:0008284 | positive regulation of cell population proliferation |
| GO:0045542 | positive regulation of cholesterol biosynthetic process |
| GO:0010595 | positive regulation of endothelial cell migration |
| GO:0050679 | positive regulation of epithelial cell proliferation |
| GO:2000347 | positive regulation of hepatocyte proliferation |
| GO:1902533 | positive regulation of intracellular signal transduction |
| GO:0043406 | positive regulation of MAP kinase activity |
| GO:0001934 | positive regulation of protein phosphorylation |
| GO:1903672 | positive regulation of sprouting angiogenesis |
| GO:0045944 | positive regulation of transcription by RNA polymerase II |
| GO:2000544 | regulation of endothelial cell chemotaxis to fibroblast growth factor |
| GO:1901509 | regulation of endothelial tube morphogenesis |
| GO:0042060 | wound healing |
| PROSITE ID | PROSITE Term |
|---|---|
| PS00247 | HBGF_FGF |
| Pfam ID | Pfam Term |
|---|---|
| PF00167 | FGF |