| Tag | Content |
|---|---|
| Uniprot ID | P05230; B2R5T0; D3DQF2; P07502; Q16588; |
| Entrez ID | 2246 |
| Genbank protein ID | AAA51673.1; BAG35227.1; AAH32697.1; AAB29057.2; AAS99352.1; AAA52638.1; EAW61881.1; EAW61885.1; CAA36206.1; AAB29058.1; AAA52446.1; EAW61882.1; AAA79245.1; CAA46661.1; AAA51672.1; |
| Genbank nucleotide ID | NM_001257209.1; NM_001257205.1; NM_001144935.1; NM_001257208.1; NM_001144934.1; NM_001144892.2; NM_033136.3; NM_000800.4; NM_001257210.1; NM_001257207.1; |
| Ensembl protein ID | ENSP00000479024; ENSP00000354231; ENSP00000338548; ENSP00000367285; ENSP00000480791; ENSP00000352329; ENSP00000396195; ENSP00000481868; ENSP00000404742; ENSP00000480980; |
| Ensembl nucleotide ID | ENSG00000113578 |
| Gene name | Fibroblast growth factor 1 |
| Gene symbol | FGF1 |
| Organism | Homo sapiens |
| NCBI taxa ID | 9606 |
| Cleft type | CPO,CL/P |
| Developmental stage | |
| Data sources | Manually collected |
| Reference | 21462296; 24613087; |
| Functional description | Plays an important role in the regulation of cell survival, cell division, angiogenesis, cell differentiation and cell migration. Functions as potent mitogen in vitro. Acts as a ligand for FGFR1 and integrins. Binds to FGFR1 in the presence of heparin leading to FGFR1 dimerization and activation via sequential autophosphorylation on tyrosine residues which act as docking sites for interacting proteins, leading to the activation of several signaling cascades. Binds to integrin ITGAV:ITGB3. Its binding to integrin, subsequent ternary complex formation with integrin and FGFR1, and the recruitment of PTPN11 to the complex are essential for FGF1 signaling. Induces the phosphorylation and activation of FGFR1, FRS2, MAPK3/ERK1, MAPK1/ERK2 and AKT1 (PubMed:18441324, PubMed:20422052). Can induce angiogenesis (PubMed:23469107). |
| Sequence | MAEGEITTFT ALTEKFNLPP GNYKKPKLLY CSNGGHFLRI LPDGTVDGTR DRSDQHIQLQ 60 LSAESVGEVY IKSTETGQYL AMDTDGLLYG SQTPNEECLF LERLEENHYN TYISKKHAEK 120 NWFVGLKKNG SCKRGPRTHY GQKAILFLPL PVSSD 155 |
Abbreviation :
CLO : cleft lip only. CPO : cleft palate only.
CLP : cleft lip and palate. CL/P : cleft lip with/without cleft palate.
For humans: CL/P, CLO, CPO, and CLP. For mice: CLO, CLP, and CPO.