CleftGeneDB-Search

Gene: FGF1

Basic information

Tag	Content
Uniprot ID	P05230; B2R5T0; D3DQF2; P07502; Q16588;
Entrez ID	2246
Genbank protein ID	AAA51673.1; BAG35227.1; AAH32697.1; AAB29057.2; AAS99352.1; AAA52638.1; EAW61881.1; EAW61885.1; CAA36206.1; AAB29058.1; AAA52446.1; EAW61882.1; AAA79245.1; CAA46661.1; AAA51672.1;
Genbank nucleotide ID	NM_001257209.1; NM_001257205.1; NM_001144935.1; NM_001257208.1; NM_001144934.1; NM_001144892.2; NM_033136.3; NM_000800.4; NM_001257210.1; NM_001257207.1;
Ensembl protein ID	ENSP00000479024; ENSP00000354231; ENSP00000338548; ENSP00000367285; ENSP00000480791; ENSP00000352329; ENSP00000396195; ENSP00000481868; ENSP00000404742; ENSP00000480980;
Ensembl nucleotide ID	ENSG00000113578
Gene name	Fibroblast growth factor 1
Gene symbol	FGF1
Organism	Homo sapiens
NCBI taxa ID	9606
Cleft type	CPO,CL/P
Developmental stage
Data sources	Manually collected
Reference	21462296; 24613087;
Functional description	Plays an important role in the regulation of cell survival, cell division, angiogenesis, cell differentiation and cell migration. Functions as potent mitogen in vitro. Acts as a ligand for FGFR1 and integrins. Binds to FGFR1 in the presence of heparin leading to FGFR1 dimerization and activation via sequential autophosphorylation on tyrosine residues which act as docking sites for interacting proteins, leading to the activation of several signaling cascades. Binds to integrin ITGAV:ITGB3. Its binding to integrin, subsequent ternary complex formation with integrin and FGFR1, and the recruitment of PTPN11 to the complex are essential for FGF1 signaling. Induces the phosphorylation and activation of FGFR1, FRS2, MAPK3/ERK1, MAPK1/ERK2 and AKT1 (PubMed:18441324, PubMed:20422052). Can induce angiogenesis (PubMed:23469107).
Sequence	MAEGEITTFT ALTEKFNLPP GNYKKPKLLY CSNGGHFLRI LPDGTVDGTR DRSDQHIQLQ 60 LSAESVGEVY IKSTETGQYL AMDTDGLLYG SQTPNEECLF LERLEENHYN TYISKKHAEK 120 NWFVGLKKNG SCKRGPRTHY GQKAILFLPL PVSSD 155

Abbreviation :
CLO : cleft lip only. CPO : cleft palate only. CLP : cleft lip and palate. CL/P : cleft lip with/without cleft palate.
For humans: CL/P, CLO, CPO, and CLP. For mice: CLO, CLP, and CPO.

Gene expression information

Gene expression in different tissues (GTEx V7)

Gene expression in different tissues (ENCODE)

Protein structural annotations

3D structure in PDB database

PDB ID
1AXM
1DJS
1DZC
1DZD
1E0O
1EVT
1HKN
1JQZ
1JT3
1JT4
1JT5
1JT7
1JTC
1JY0
1K5U
1K5V
1M16
1NZK
1P63
1PZZ
1Q03
1Q04
1QCT
1RG8
1RML
1RY7
1YTO
1Z2V
1Z4S
2AFG
2AQZ
2AXM
2ERM
2HW9
2HWA
2HWM
2HZ9
2K43
2K4A
2K8R
2KI4
2KI6
2NTD
2Q9X
2RQ9
3B9U
3BA4
3BA5
3BA7
3BAD
3BAG
3BAH
3BAO
3BAQ
3BAU
3BAV
3BB2
3CQA
3CRG
3CRH
3CRI
3CU1
3FGM
3FJ8
3FJ9
3FJA
3FJB
3FJC
3FJD
3FJE
3FJF
3FJH
3FJI
3FJJ
3FJK
3HOM
3JUT
3K1X
3O3Q
3OJ2
3OJM
3OJV
3UD7
3UD8
3UD9
3UDA
4J23
4Q91
4Q9G
4Q9P
4QAL
4QBC
4QBV
4QC4
4QO3
4XKI
4YOL
1DZC
1RG8
2K43
3B9U
3O3Q
3OJ2
3OJM

Protein disorder information

Orthologous information

Relation	Gene symbol	Entrez ID	UniProt ID	Cleft type	Developmental stage	Species	Evidence	Details
1:1 ortholog	FGF1	281160	P03968			Bos taurus	Prediction	More>>
1:1 ortholog	FGF1	607724	J9NTP4			Canis lupus familiaris	Prediction	More>>
1:1 ortholog	FGF1	102188850	A0A142I1Y1			Capra hircus	Prediction	More>>
1:1 ortholog	FGF1	100033960	F6WDN0			Equus caballus	Prediction	More>>
1:1 ortholog	FGF1	2246	P05230	CPO,CL/P		Homo sapiens	Publication	More>>
1:1 ortholog	Fgf1	14164	P61148		E14.5	Mus musculus	Prediction	More>>
1:1 ortholog	FGF1	462158	A0A2J8NIY5			Pan troglodytes	Prediction	More>>
1:1 ortholog	FGF1	397497	F1RM38			Sus scrofa	Prediction	More>>
1:1 ortholog	FGF1	100328898	B7NZB1			Oryctolagus cuniculus	Prediction	More>>
1:1 ortholog	Fgf1	25317	P61149			Rattus norvegicus	Prediction	More>>

Identified variants/mutations related to cleft phenotype

Gene symbol	Significant Variants/SNPS	Methods	PubMed ID
FGF1	rs34010C>A	T-ARMS-PCR	24613087
FGF1	rs34010G>T (decrease risk)	Genotyping	21462296

Other genetic variants/mutations

ID	Variant	Type	Disease	Chromosome\Coordinate	Evidence
rs552755699	p.Ala2Gly	missense variant	-	NC_000005.10:g.142614123G>C	1000Genomes,ExAC,gnomAD
rs758882195	p.Ala2Thr	missense variant	-	NC_000005.10:g.142614124C>T	ExAC,gnomAD
NCI-TCGA novel	p.Glu3Lys	missense variant	-	NC_000005.10:g.142614121C>T	NCI-TCGA
rs138110926	p.Thr7Ile	missense variant	-	NC_000005.10:g.142614108G>A	ESP,ExAC,TOPMed,gnomAD
NCI-TCGA novel	p.Thr8Ile	missense variant	-	NC_000005.10:g.142614105G>A	NCI-TCGA
rs1302333841	p.Ala11Val	missense variant	-	NC_000005.10:g.142614096G>A	gnomAD
rs1302333841	p.Ala11Asp	missense variant	-	NC_000005.10:g.142614096G>T	gnomAD
rs1403446036	p.Leu12Pro	missense variant	-	NC_000005.10:g.142614093A>G	gnomAD
rs375379946	p.Thr13Ile	missense variant	-	NC_000005.10:g.142614090G>A	ESP,ExAC,TOPMed,gnomAD
rs375379946	p.Thr13Asn	missense variant	-	NC_000005.10:g.142614090G>T	ESP,ExAC,TOPMed,gnomAD
rs529994538	p.Glu14Gln	missense variant	-	NC_000005.10:g.142614088C>G	ExAC,TOPMed,gnomAD
rs529994538	p.Glu14Lys	missense variant	-	NC_000005.10:g.142614088C>T	ExAC,TOPMed,gnomAD
rs997547008	p.Lys15Thr	missense variant	-	NC_000005.10:g.142614084T>G	TOPMed,gnomAD
rs1425477789	p.Lys15Glu	missense variant	-	NC_000005.10:g.142614085T>C	TOPMed
rs1174067481	p.Pro19Leu	missense variant	-	NC_000005.10:g.142614072G>A	TOPMed
NCI-TCGA novel	p.Pro19Ser	missense variant	-	NC_000005.10:g.142614073G>A	NCI-TCGA
rs745732625	p.Gly21Arg	missense variant	-	NC_000005.10:g.142614067C>T	ExAC,TOPMed,gnomAD
rs17223632	p.Gly21Glu	missense variant	-	NC_000005.10:g.142614066C>T	UniProt,dbSNP
VAR_021357	p.Gly21Glu	missense variant	-	NC_000005.10:g.142614066C>T	UniProt
rs17223632	p.Gly21Glu	missense variant	-	NC_000005.10:g.142614066C>T	1000Genomes,ESP,ExAC,TOPMed,gnomAD
rs745732625	p.Gly21Arg	missense variant	-	NC_000005.10:g.142614067C>G	ExAC,TOPMed,gnomAD
NCI-TCGA novel	p.Gly21Trp	missense variant	-	NC_000005.10:g.142614067C>A	NCI-TCGA
rs770703997	p.Lys25Asn	missense variant	-	NC_000005.10:g.142614053C>A	ExAC,TOPMed,gnomAD
rs1368636111	p.Leu28His	missense variant	-	NC_000005.10:g.142614045A>T	TOPMed
rs1004435823	p.Leu29Ile	missense variant	-	NC_000005.10:g.142614043G>T	TOPMed
rs781436637	p.Cys31Trp	missense variant	-	NC_000005.10:g.142614035A>C	ExAC,gnomAD
rs748324402	p.Cys31Arg	missense variant	-	NC_000005.10:g.142614037A>G	ExAC,gnomAD
rs1281851920	p.Cys31Tyr	missense variant	-	NC_000005.10:g.142614036C>T	TOPMed
rs1323281277	p.Ser32Ile	missense variant	-	NC_000005.10:g.142614033C>A	TOPMed
rs557322408	p.Ser32Gly	missense variant	-	NC_000005.10:g.142614034T>C	1000Genomes,ExAC,gnomAD
rs780745181	p.Gly34Arg	missense variant	-	NC_000005.10:g.142614028C>T	ExAC,TOPMed,gnomAD
rs1434024570	p.Gly35Val	missense variant	-	NC_000005.10:g.142614024C>A	gnomAD
COSM281150	p.Gly35Asp	missense variant	Variant assessed as Somatic; MODERATE impact.	NC_000005.10:g.142614024C>T	NCI-TCGA Cosmic
NCI-TCGA novel	p.Gly35AlaPheSerTerUnk	frameshift	-	NC_000005.10:g.142614024C>-	NCI-TCGA
rs758967005	p.His36Tyr	missense variant	-	NC_000005.10:g.142614022G>A	ExAC,gnomAD
rs1323743663	p.Phe37Leu	missense variant	-	NC_000005.10:g.142614019A>G	gnomAD
rs779156328	p.Leu41Arg	missense variant	-	NC_000005.10:g.142614006A>C	ExAC,gnomAD
rs770103681	p.Pro42Leu	missense variant	-	NC_000005.10:g.142614003G>A	ExAC,TOPMed,gnomAD
rs763784465	p.Asp43Gly	missense variant	-	NC_000005.10:g.142614000T>C	ExAC,gnomAD
rs760222333	p.Gly44Asp	missense variant	-	NC_000005.10:g.142613997C>T	ExAC,gnomAD
NCI-TCGA novel	p.Gly44Cys	missense variant	-	NC_000005.10:g.142613998C>A	NCI-TCGA
rs1490756504	p.Asp47Gly	missense variant	-	NC_000005.10:g.142613988T>C	TOPMed
rs752202262	p.Asp47His	missense variant	-	NC_000005.10:g.142613989C>G	ExAC,TOPMed,gnomAD
rs767502862	p.Gly48Ala	missense variant	-	NC_000005.10:g.142613985C>G	ExAC,TOPMed,gnomAD
rs1222529936	p.Arg52Lys	missense variant	-	NC_000005.10:g.142613973C>T	gnomAD
rs770662903	p.Asp54Glu	missense variant	-	NC_000005.10:g.142613966G>T	ExAC,gnomAD
rs200931712	p.Asp54Asn	missense variant	-	NC_000005.10:g.142613968C>T	1000Genomes,ExAC,TOPMed,gnomAD
rs1397972024	p.Leu59Pro	missense variant	-	NC_000005.10:g.142600799A>G	gnomAD
rs968262011	p.Gln60Ter	stop gained	-	NC_000005.10:g.142600797G>A	TOPMed
rs1218989496	p.Leu61Phe	missense variant	-	NC_000005.10:g.142600794G>A	TOPMed
rs775873647	p.Ala63Val	missense variant	-	NC_000005.10:g.142600787G>A	ExAC,TOPMed,gnomAD
rs774480739	p.Val66Met	missense variant	-	NC_000005.10:g.142600779C>T	ExAC,TOPMed,gnomAD
rs773671222	p.Glu68Asp	missense variant	-	NC_000005.10:g.142600771C>G	ExAC,gnomAD
rs749809722	p.Glu68Lys	missense variant	-	NC_000005.10:g.142600773C>T	ExAC,gnomAD
rs773671222	p.Glu68Asp	missense variant	-	NC_000005.10:g.142600771C>A	ExAC,gnomAD
rs1415742259	p.Val69Leu	missense variant	-	NC_000005.10:g.142600770C>A	TOPMed
rs1318889609	p.Ile71Arg	missense variant	-	NC_000005.10:g.142600763A>C	TOPMed,gnomAD
NCI-TCGA novel	p.Lys72Glu	missense variant	-	NC_000005.10:g.142600761T>C	NCI-TCGA
rs141211666	p.Ser73Asn	missense variant	-	NC_000005.10:g.142600757C>T	ESP,ExAC,TOPMed,gnomAD
rs768468212	p.Thr74Ile	missense variant	-	NC_000005.10:g.142600754G>A	ExAC,gnomAD
rs148224095	p.Glu75Gln	missense variant	-	NC_000005.10:g.142600752C>G	ESP,ExAC,TOPMed,gnomAD
rs148224095	p.Glu75Lys	missense variant	-	NC_000005.10:g.142600752C>T	ESP,ExAC,TOPMed,gnomAD
rs565742349	p.Thr76Pro	missense variant	-	NC_000005.10:g.142600749T>G	1000Genomes,ExAC
rs375407078	p.Gly77Ser	missense variant	-	NC_000005.10:g.142600746C>T	ESP,TOPMed,gnomAD
rs886552961	p.Gln78His	missense variant	-	NC_000005.10:g.142600741C>A	TOPMed
rs200708364	p.Gln78Arg	missense variant	-	NC_000005.10:g.142600742T>C	ESP,ExAC,TOPMed,gnomAD
rs200708364	p.Gln78Leu	missense variant	-	NC_000005.10:g.142600742T>A	ESP,ExAC,TOPMed,gnomAD
rs757163595	p.Leu80Ser	missense variant	-	NC_000005.10:g.142600736A>G	ExAC,gnomAD
rs1192531296	p.Thr84Ser	missense variant	-	NC_000005.10:g.142600724G>C	gnomAD
rs1488617074	p.Asp85Asn	missense variant	-	NC_000005.10:g.142600722C>T	TOPMed,gnomAD
rs767694313	p.Gly86Arg	missense variant	-	NC_000005.10:g.142600719C>T	ExAC,TOPMed,gnomAD
NCI-TCGA novel	p.Leu88Ser	missense variant	-	NC_000005.10:g.142600712A>G	NCI-TCGA
rs774373472	p.Tyr89Phe	missense variant	-	NC_000005.10:g.142600709T>A	ExAC,gnomAD
rs774373472	p.Tyr89Cys	missense variant	-	NC_000005.10:g.142600709T>C	ExAC,gnomAD
rs762894941	p.Gly90Ser	missense variant	-	NC_000005.10:g.142600707C>T	ExAC,TOPMed,gnomAD
rs773757340	p.Gly90Asp	missense variant	-	NC_000005.10:g.142600706C>T	ExAC,gnomAD
rs1174301824	p.Gln92Arg	missense variant	-	NC_000005.10:g.142595483T>C	gnomAD
NCI-TCGA novel	p.Glu96Asp	missense variant	-	NC_000005.10:g.142595470C>A	NCI-TCGA
COSM275164	p.Phe100Leu	missense variant	Variant assessed as Somatic; MODERATE impact.	NC_000005.10:g.142595460A>G	NCI-TCGA Cosmic
rs778584449	p.Arg103Ser	missense variant	-	NC_000005.10:g.142595449C>G	ExAC,gnomAD
rs1254681607	p.Glu105Lys	missense variant	-	NC_000005.10:g.142595445C>T	gnomAD
rs1202711739	p.Glu106Lys	missense variant	-	NC_000005.10:g.142595442C>T	TOPMed,gnomAD
NCI-TCGA novel	p.Glu106Asp	missense variant	-	NC_000005.10:g.142595440C>A	NCI-TCGA
rs770501980	p.His108Asp	missense variant	-	NC_000005.10:g.142595436G>C	ExAC,gnomAD
NCI-TCGA novel	p.Tyr109Asp	missense variant	-	NC_000005.10:g.142595433A>C	NCI-TCGA
COSM1434817	p.Asn110Thr	missense variant	Variant assessed as Somatic; MODERATE impact.	NC_000005.10:g.142595429T>G	NCI-TCGA Cosmic
COSM3852317	p.Thr111Pro	missense variant	Variant assessed as Somatic; MODERATE impact.	NC_000005.10:g.142595427T>G	NCI-TCGA Cosmic
NCI-TCGA novel	p.Thr111Ile	missense variant	-	NC_000005.10:g.142595426G>A	NCI-TCGA
NCI-TCGA novel	p.Tyr112His	missense variant	-	NC_000005.10:g.142595424A>G	NCI-TCGA
rs561960626	p.Ile113Val	missense variant	-	NC_000005.10:g.142595421T>C	1000Genomes,ExAC,gnomAD
rs1271039014	p.Ile113Thr	missense variant	-	NC_000005.10:g.142595420A>G	gnomAD
rs1244139413	p.Lys115Thr	missense variant	-	NC_000005.10:g.142595414T>G	TOPMed,gnomAD
NCI-TCGA novel	p.Lys115Asn	missense variant	-	NC_000005.10:g.142595413C>A	NCI-TCGA
rs1338842264	p.Lys116Asn	missense variant	-	NC_000005.10:g.142595410C>G	gnomAD
rs1357397469	p.His117Gln	missense variant	-	NC_000005.10:g.142595407A>T	gnomAD
rs369740938	p.Ala118Pro	missense variant	-	NC_000005.10:g.142595406C>G	ESP,ExAC,TOPMed,gnomAD
rs1415333814	p.Ala118Val	missense variant	-	NC_000005.10:g.142595405G>A	gnomAD
rs1305923663	p.Glu119Lys	missense variant	-	NC_000005.10:g.142595403C>T	gnomAD
NCI-TCGA novel	p.Lys120Asn	missense variant	-	NC_000005.10:g.142595398C>A	NCI-TCGA
rs780390744	p.Trp122Cys	missense variant	-	NC_000005.10:g.142595392C>A	ExAC,gnomAD
rs902995255	p.Gly125Asp	missense variant	-	NC_000005.10:g.142595384C>T	TOPMed
rs1190163641	p.Lys127Arg	missense variant	-	NC_000005.10:g.142595378T>C	gnomAD
rs765303323	p.Ser131Asn	missense variant	-	NC_000005.10:g.142595366C>T	ExAC,gnomAD
rs761839384	p.Cys132Gly	missense variant	-	NC_000005.10:g.142595364A>C	ExAC,TOPMed,gnomAD
rs1222942974	p.Cys132Phe	missense variant	-	NC_000005.10:g.142595363C>A	TOPMed
rs754388820	p.Lys133Glu	missense variant	-	NC_000005.10:g.142595361T>C	ExAC,gnomAD
rs764484123	p.Arg134Cys	missense variant	-	NC_000005.10:g.142595358G>A	ExAC,gnomAD
rs145843967	p.Arg134His	missense variant	-	NC_000005.10:g.142595357C>T	ESP,ExAC,TOPMed,gnomAD
rs145843967	p.Arg134Pro	missense variant	-	NC_000005.10:g.142595357C>G	ESP,ExAC,TOPMed,gnomAD
rs759270544	p.Gly135Ser	missense variant	-	NC_000005.10:g.142595355C>T	ExAC,TOPMed,gnomAD
rs774109079	p.Pro136Ser	missense variant	-	NC_000005.10:g.142595352G>A	ExAC,TOPMed,gnomAD
rs770590235	p.Arg137Trp	missense variant	-	NC_000005.10:g.142595349G>A	ExAC,TOPMed,gnomAD
rs146745580	p.Arg137Gln	missense variant	-	NC_000005.10:g.142595348C>T	1000Genomes,ESP,ExAC,TOPMed,gnomAD
NCI-TCGA novel	p.Gln142Ter	stop gained	-	NC_000005.10:g.142595334G>A	NCI-TCGA
rs769616526	p.Ile145Val	missense variant	-	NC_000005.10:g.142595325T>C	ExAC,gnomAD
rs748034939	p.Ile145Thr	missense variant	-	NC_000005.10:g.142595324A>G	ExAC,TOPMed,gnomAD
rs748034939	p.Ile145Asn	missense variant	-	NC_000005.10:g.142595324A>T	ExAC,TOPMed,gnomAD
rs780860378	p.Leu146Phe	missense variant	-	NC_000005.10:g.142595320C>A	ExAC
rs754699487	p.Phe147Leu	missense variant	-	NC_000005.10:g.142595319A>G	ExAC,gnomAD
COSM3776388	p.Leu148Phe	missense variant	Variant assessed as Somatic; MODERATE impact.	NC_000005.10:g.142595316G>A	NCI-TCGA Cosmic
rs201277854	p.Leu148Pro	missense variant	-	NC_000005.10:g.142595315A>G	ExAC,gnomAD
rs757372975	p.Pro149Leu	missense variant	-	NC_000005.10:g.142595312G>A	ExAC,gnomAD
rs764725960	p.Leu150Met	missense variant	-	NC_000005.10:g.142595310G>T	ExAC,gnomAD
NCI-TCGA novel	p.Leu150HisPheSerTerUnk	frameshift	-	NC_000005.10:g.142595309_142595310insT	NCI-TCGA
rs1198361298	p.Val152Ile	missense variant	-	NC_000005.10:g.142595304C>T	TOPMed,gnomAD
rs1198361298	p.Val152Leu	missense variant	-	NC_000005.10:g.142595304C>G	TOPMed,gnomAD
COSM3994079	p.Val152Phe	missense variant	Variant assessed as Somatic; MODERATE impact.	NC_000005.10:g.142595304C>A	NCI-TCGA Cosmic
rs1450056118	p.Asp155Glu	missense variant	-	NC_000005.10:g.142595293A>T	gnomAD

Disease or phenotype associated information

Disease ID	Disease Name	Disease Type	Source
C0001080	Achondroplasia	disease	BEFREE
C0001175	Acquired Immunodeficiency Syndrome	group	BEFREE
C0001418	Adenocarcinoma	group	BEFREE
C0002395	Alzheimer's Disease	disease	BEFREE;LHGDN
C0002793	Anaplasia	disease	BEFREE
C0003850	Arteriosclerosis	disease	BEFREE
C0003873	Rheumatoid Arthritis	disease	BEFREE
C0004153	Atherosclerosis	disease	BEFREE
C0004763	Barrett Esophagus	disease	BEFREE
C0005684	Malignant neoplasm of urinary bladder	disease	BEFREE
C0005695	Bladder Neoplasm	group	BEFREE
C0006142	Malignant neoplasm of breast	disease	BEFREE
C0006826	Malignant Neoplasms	group	BEFREE
C0007102	Malignant tumor of colon	disease	BEFREE
C0007103	Malignant neoplasm of endometrium	disease	BEFREE
C0007786	Brain Ischemia	disease	RGD
C0008924	Cleft upper lip	disease	LHGDN
C0008925	Cleft Palate	disease	LHGDN
C0014175	Endometriosis	disease	BEFREE;LHGDN
C0017638	Glioma	disease	BEFREE
C0018799	Heart Diseases	group	BEFREE
C0020538	Hypertensive disease	group	BEFREE
C0020649	Hypotension	phenotype	CTD_human
C0021368	Inflammation	phenotype	LHGDN
C0022408	Arthropathy	group	BEFREE
C0022548	Keloid	phenotype	BEFREE
C0023267	Fibroid Tumor	group	LHGDN
C0023418	leukemia	disease	BEFREE;CTD_human
C0023467	Leukemia, Myelocytic, Acute	disease	BEFREE
C0024121	Lung Neoplasms	group	BEFREE
C0024232	Lymphatic Metastasis	disease	BEFREE
C0025202	melanoma	disease	BEFREE
C0025500	Mesothelioma	disease	BEFREE;CTD_human
C0026764	Multiple Myeloma	disease	BEFREE
C0027627	Neoplasm Metastasis	phenotype	BEFREE
C0027859	Acoustic Neuroma	disease	BEFREE
C0028754	Obesity	disease	BEFREE
C0029408	Degenerative polyarthritis	disease	BEFREE
C0029463	Osteosarcoma	disease	BEFREE
C0029925	Ovarian Carcinoma	disease	BEFREE
C0034069	Pulmonary Fibrosis	disease	BEFREE;CTD_human
C0035335	Retinoblastoma	disease	BEFREE
C0038454	Cerebrovascular accident	group	BEFREE
C0043094	Weight Gain	phenotype	CTD_human
C0085786	Hamman-Rich syndrome	disease	CTD_human
C0149521	Pancreatitis, Chronic	disease	BEFREE
C0149782	Squamous cell carcinoma of lung	disease	BEFREE
C0149925	Small cell carcinoma of lung	disease	BEFREE
C0151744	Myocardial Ischemia	disease	BEFREE;CTD_human
C0153676	Secondary malignant neoplasm of lung	disease	BEFREE
C0178874	Tumor Progression	phenotype	BEFREE
C0206650	Fibroadenoma	disease	BEFREE
C0238288	Muscular Dystrophy, Facioscapulohumeral	disease	BEFREE
C0279628	Adenocarcinoma Of Esophagus	disease	BEFREE
C0279746	Adenocarcinoma of salivary gland	disease	BEFREE
C0281361	Adenocarcinoma of pancreas	disease	BEFREE
C0341858	Endometriosis of uterus	disease	BEFREE
C0376358	Malignant neoplasm of prostate	disease	BEFREE
C0400966	Non-alcoholic Fatty Liver Disease	disease	BEFREE
C0476089	Endometrial Carcinoma	disease	BEFREE
C0524851	Neurodegenerative Disorders	group	BEFREE
C0585442	Osteosarcoma of bone	disease	BEFREE
C0596263	Carcinogenesis	phenotype	BEFREE
C0600139	Prostate carcinoma	disease	BEFREE
C0678222	Breast Carcinoma	disease	BEFREE
C0699790	Colon Carcinoma	disease	BEFREE
C0699885	Carcinoma of bladder	disease	BEFREE
C0740302	5q-syndrome	disease	BEFREE
C0796154	SIMPSON-GOLABI-BEHMEL SYNDROME, TYPE 1	disease	BEFREE
C0853897	Diabetic Cardiomyopathies	disease	BEFREE
C0919267	ovarian neoplasm	disease	BEFREE;CTD_human;LHGDN
C1140680	Malignant neoplasm of ovary	disease	BEFREE;CTD_human
C1145670	Respiratory Failure	disease	BEFREE
C1257763	Overnutrition	phenotype	BEFREE
C1258666	Myxoid cyst	disease	BEFREE
C1261473	Sarcoma	group	BEFREE
C1292779	Myelodysplastic Syndrome with Isolated del(5q)	disease	BEFREE
C1298180	Single tumor	phenotype	BEFREE
C1306459	Primary malignant neoplasm	group	BEFREE
C1383860	Cardiac Hypertrophy	phenotype	GWASCAT;GWASDB
C1458155	Mammary Neoplasms	group	BEFREE;LHGDN
C1704436	Peripheral Arterial Diseases	group	BEFREE
C1802398	Chromosome 5, trisomy 5q	disease	BEFREE
C1855179	CATARACT, ANTERIOR POLAR	disease	BEFREE
C1883486	Uterine Corpus Cancer	disease	BEFREE
C2239176	Liver carcinoma	disease	BEFREE
C2711227	Steatohepatitis	disease	BEFREE
C2945695	Limb ischemia	disease	BEFREE

Gene Ontology (GO)/biological pathways

GO:Molecular Function

GO ID	GO Term	Evidence
GO:0005104	fibroblast growth factor receptor binding	IPI
GO:0005104	fibroblast growth factor receptor binding	IMP
GO:0005178	integrin binding	IDA
GO:0005515	protein binding	IPI
GO:0008083	growth factor activity	IDA
GO:0008201	heparin binding	IMP
GO:0008201	heparin binding	IDA
GO:0030544	Hsp70 protein binding	IEA
GO:0044548	S100 protein binding	IPI

GO:Biological Process

GO ID	GO Term	Evidence
GO:0000165	MAPK cascade	TAS
GO:0000187	activation of MAPK activity	IMP
GO:0001525	angiogenesis	IEA
GO:0001759	organ induction	IEA
GO:0007165	signal transduction	NAS
GO:0007275	multicellular organism development	TAS
GO:0008284	positive regulation of cell population proliferation	IGI
GO:0008284	positive regulation of cell population proliferation	IMP
GO:0008543	fibroblast growth factor receptor signaling pathway	IPI
GO:0008543	fibroblast growth factor receptor signaling pathway	IGI
GO:0008543	fibroblast growth factor receptor signaling pathway	IMP
GO:0008543	fibroblast growth factor receptor signaling pathway	IDA
GO:0008543	fibroblast growth factor receptor signaling pathway	TAS
GO:0009653	anatomical structure morphogenesis	TAS
GO:0010595	positive regulation of endothelial cell migration	IMP
GO:0030154	cell differentiation	IEA
GO:0030324	lung development	IEA
GO:0030335	positive regulation of cell migration	IMP
GO:0030335	positive regulation of cell migration	IDA
GO:0032148	activation of protein kinase B activity	IMP
GO:0034605	cellular response to heat	IDA
GO:0042060	wound healing	IDA
GO:0043406	positive regulation of MAP kinase activity	IDA
GO:0045542	positive regulation of cholesterol biosynthetic process	IDA
GO:0045766	positive regulation of angiogenesis	IDA
GO:0045944	positive regulation of transcription by RNA polymerase II	IDA
GO:0051781	positive regulation of cell division	IDA
GO:0051897	positive regulation of protein kinase B signaling	TAS
GO:0060681	branch elongation involved in ureteric bud branching	IDA
GO:0072163	mesonephric epithelium development	IDA
GO:1901509	regulation of endothelial tube morphogenesis	IMP
GO:1902533	positive regulation of intracellular signal transduction	IDA
GO:1903672	positive regulation of sprouting angiogenesis	IMP
GO:2000347	positive regulation of hepatocyte proliferation	IEA
GO:2000544	regulation of endothelial cell chemotaxis to fibroblast growth factor	IDA

GO:Cellular Component

GO ID	GO Term	Evidence
GO:0005576	extracellular region	IDA
GO:0005576	extracellular region	TAS
GO:0005615	extracellular space	IDA
GO:0005654	nucleoplasm	IDA
GO:0005730	nucleolus	IEA
GO:0005829	cytosol	IDA
GO:0005938	cell cortex	IEA
GO:0031012	extracellular matrix	IEA

Reactome Pathway

Reactome ID	Reactome Term	Evidence
R-HSA-109704	PI3K Cascade	TAS
R-HSA-112399	IRS-mediated signalling	TAS
R-HSA-1226099	Signaling by FGFR in disease	TAS
R-HSA-1226099	Signaling by FGFR in disease	IEA
R-HSA-1257604	PIP3 activates AKT signaling	TAS
R-HSA-1280215	Cytokine Signaling in Immune system	TAS
R-HSA-162582	Signal Transduction	TAS
R-HSA-1643685	Disease	TAS
R-HSA-1643685	Disease	IEA
R-HSA-168256	Immune System	TAS
R-HSA-1839122	Signaling by activated point mutants of FGFR1	TAS
R-HSA-1839124	FGFR1 mutant receptor activation	TAS
R-HSA-1839126	FGFR2 mutant receptor activation	TAS
R-HSA-1839126	FGFR2 mutant receptor activation	IEA
R-HSA-1839130	Signaling by activated point mutants of FGFR3	TAS
R-HSA-190236	Signaling by FGFR	TAS
R-HSA-190239	FGFR3 ligand binding and activation	TAS
R-HSA-190241	FGFR2 ligand binding and activation	TAS
R-HSA-190242	FGFR1 ligand binding and activation	TAS
R-HSA-190322	FGFR4 ligand binding and activation	TAS
R-HSA-190370	FGFR1b ligand binding and activation	TAS
R-HSA-190371	FGFR3b ligand binding and activation	TAS
R-HSA-190372	FGFR3c ligand binding and activation	TAS
R-HSA-190373	FGFR1c ligand binding and activation	TAS
R-HSA-190375	FGFR2c ligand binding and activation	TAS
R-HSA-190377	FGFR2b ligand binding and activation	TAS
R-HSA-199418	Negative regulation of the PI3K/AKT network	TAS
R-HSA-2033514	FGFR3 mutant receptor activation	TAS
R-HSA-2033519	Activated point mutants of FGFR2	TAS
R-HSA-2219528	PI3K/AKT Signaling in Cancer	TAS
R-HSA-2219530	Constitutive Signaling by Aberrant PI3K in Cancer	TAS
R-HSA-2404192	Signaling by Type 1 Insulin-like Growth Factor 1 Receptor (IGF1R)	TAS
R-HSA-2428924	IGF1R signaling cascade	TAS
R-HSA-2428928	IRS-related events triggered by IGF1R	TAS
R-HSA-5654219	Phospholipase C-mediated cascade: FGFR1	TAS
R-HSA-5654221	Phospholipase C-mediated cascade; FGFR2	TAS
R-HSA-5654227	Phospholipase C-mediated cascade; FGFR3	TAS
R-HSA-5654228	Phospholipase C-mediated cascade; FGFR4	TAS
R-HSA-5654687	Downstream signaling of activated FGFR1	TAS
R-HSA-5654688	SHC-mediated cascade:FGFR1	TAS
R-HSA-5654689	PI-3K cascade:FGFR1	TAS
R-HSA-5654693	FRS-mediated FGFR1 signaling	TAS
R-HSA-5654695	PI-3K cascade:FGFR2	TAS
R-HSA-5654696	Downstream signaling of activated FGFR2	TAS
R-HSA-5654699	SHC-mediated cascade:FGFR2	TAS
R-HSA-5654700	FRS-mediated FGFR2 signaling	TAS
R-HSA-5654704	SHC-mediated cascade:FGFR3	TAS
R-HSA-5654706	FRS-mediated FGFR3 signaling	TAS
R-HSA-5654708	Downstream signaling of activated FGFR3	TAS
R-HSA-5654710	PI-3K cascade:FGFR3	TAS
R-HSA-5654712	FRS-mediated FGFR4 signaling	TAS
R-HSA-5654716	Downstream signaling of activated FGFR4	TAS
R-HSA-5654719	SHC-mediated cascade:FGFR4	TAS
R-HSA-5654720	PI-3K cascade:FGFR4	TAS
R-HSA-5654726	Negative regulation of FGFR1 signaling	TAS
R-HSA-5654727	Negative regulation of FGFR2 signaling	TAS
R-HSA-5654732	Negative regulation of FGFR3 signaling	TAS
R-HSA-5654733	Negative regulation of FGFR4 signaling	TAS
R-HSA-5654736	Signaling by FGFR1	TAS
R-HSA-5654738	Signaling by FGFR2	TAS
R-HSA-5654741	Signaling by FGFR3	TAS
R-HSA-5654743	Signaling by FGFR4	TAS
R-HSA-5655253	Signaling by FGFR2 in disease	TAS
R-HSA-5655253	Signaling by FGFR2 in disease	IEA
R-HSA-5655302	Signaling by FGFR1 in disease	TAS
R-HSA-5655332	Signaling by FGFR3 in disease	TAS
R-HSA-5663202	Diseases of signal transduction	TAS
R-HSA-5663202	Diseases of signal transduction	IEA
R-HSA-5673001	RAF/MAP kinase cascade	TAS
R-HSA-5683057	MAPK family signaling cascades	TAS
R-HSA-5684996	MAPK1/MAPK3 signaling	TAS
R-HSA-6811558	PI5P, PP2A and IER3 Regulate PI3K/AKT Signaling	TAS
R-HSA-74751	Insulin receptor signalling cascade	TAS
R-HSA-74752	Signaling by Insulin receptor	TAS
R-HSA-8851708	Signaling by FGFR2 IIIa TM	IEA
R-HSA-8853338	Signaling by FGFR3 point mutants in cancer	TAS
R-HSA-9006925	Intracellular signaling by second messengers	TAS
R-HSA-9006934	Signaling by Receptor Tyrosine Kinases	TAS
R-HSA-9607240	FLT3 Signaling	TAS

Drugs and compounds information

ID	Drug Name	Action	PubMed
C026486	1,2,5,6-dibenzanthracene	1,2,5,6-dibenzanthracene results in increased expression of FGF1 mRNA	26377693
D015058	1-Naphthylisothiocyanate	1-Naphthylisothiocyanate results in increased expression of FGF1 mRNA	30723492
C029790	2,2',3',4,4',5-hexachlorobiphenyl	[2,4,4'-trichlorobiphenyl co-treated with 2,5,2',5'-tetrachlorobiphenyl co-treated with 2,4,5,2',5'-pentachlorobiphenyl co-treated with 2,2',3',4,4',5-hexachlorobiphenyl co-treated with 2,4,5,2',4',5'-hexachlorobiphenyl co-treated with PCB 180] results in decreased expression of FGF1 mRNA	25510870
C029141	2,2,5,7,8-pentamethyl-1-hydroxychroman	2,2,5,7,8-pentamethyl-1-hydroxychroman results in increased expression of FGF1 mRNA	21920950
C093973	2-(2-amino-3-methoxyphenyl)-4H-1-benzopyran-4-one	FGF1 protein inhibits the reaction [2-(2-amino-3-methoxyphenyl)-4H-1-benzopyran-4-one results in decreased phosphorylation of and results in decreased activity of MAPK1 protein]	15231676
C093973	2-(2-amino-3-methoxyphenyl)-4H-1-benzopyran-4-one	FGF1 protein inhibits the reaction [2-(2-amino-3-methoxyphenyl)-4H-1-benzopyran-4-one results in decreased phosphorylation of and results in decreased activity of MAPK3 protein]	15231676
C093973	2-(2-amino-3-methoxyphenyl)-4H-1-benzopyran-4-one	2-(2-amino-3-methoxyphenyl)-4H-1-benzopyran-4-one results in decreased activity of FGF1 protein	15695173
C093973	2-(2-amino-3-methoxyphenyl)-4H-1-benzopyran-4-one	2-(2-amino-3-methoxyphenyl)-4H-1-benzopyran-4-one inhibits the reaction [FGF1 protein results in increased expression of POSTN mRNA]	15121739
C093973	2-(2-amino-3-methoxyphenyl)-4H-1-benzopyran-4-one	2-(2-amino-3-methoxyphenyl)-4H-1-benzopyran-4-one inhibits the reaction [FGF1 protein results in increased expression of SPP1 mRNA]	15121739
C093973	2-(2-amino-3-methoxyphenyl)-4H-1-benzopyran-4-one	2-(2-amino-3-methoxyphenyl)-4H-1-benzopyran-4-one promotes the reaction [FGF1 protein results in increased expression of UCP1 mRNA]	11742803
C488185	2-(2-chloro-4-iodophenylamino)-N-cyclopropylmethoxy-3,4-difluoro-5-bromobenzamide	FGF1 protein inhibits the reaction [2-(2-chloro-4-iodophenylamino)-N-cyclopropylmethoxy-3,4-difluoro-5-bromobenzamide results in decreased phosphorylation of and results in decreased activity of MAPK1 protein]	15231676
C488185	2-(2-chloro-4-iodophenylamino)-N-cyclopropylmethoxy-3,4-difluoro-5-bromobenzamide	FGF1 protein inhibits the reaction [2-(2-chloro-4-iodophenylamino)-N-cyclopropylmethoxy-3,4-difluoro-5-bromobenzamide results in decreased phosphorylation of and results in decreased activity of MAPK3 protein]	15231676
C081766	2,4,4'-trichlorobiphenyl	[2,4,4'-trichlorobiphenyl co-treated with 2,5,2',5'-tetrachlorobiphenyl co-treated with 2,4,5,2',5'-pentachlorobiphenyl co-treated with 2,2',3',4,4',5-hexachlorobiphenyl co-treated with 2,4,5,2',4',5'-hexachlorobiphenyl co-treated with PCB 180] results in decreased expression of FGF1 mRNA	25510870
C014024	2,4,5,2',4',5'-hexachlorobiphenyl	[2,4,4'-trichlorobiphenyl co-treated with 2,5,2',5'-tetrachlorobiphenyl co-treated with 2,4,5,2',5'-pentachlorobiphenyl co-treated with 2,2',3',4,4',5-hexachlorobiphenyl co-treated with 2,4,5,2',4',5'-hexachlorobiphenyl co-treated with PCB 180] results in decreased expression of FGF1 mRNA	25510870
C009828	2,4,5,2',5'-pentachlorobiphenyl	[2,4,4'-trichlorobiphenyl co-treated with 2,5,2',5'-tetrachlorobiphenyl co-treated with 2,4,5,2',5'-pentachlorobiphenyl co-treated with 2,2',3',4,4',5-hexachlorobiphenyl co-treated with 2,4,5,2',4',5'-hexachlorobiphenyl co-treated with PCB 180] results in decreased expression of FGF1 mRNA	25510870
C085911	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one inhibits the reaction [FGF1 protein results in increased phosphorylation of AKT1 protein]	16272825
C085911	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one results in decreased activity of FGF1 protein	15695173
C085911	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one inhibits the reaction [FGF1 protein results in increased expression of POSTN mRNA]	15121739; 16325820;
C085911	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one promotes the reaction [FGF1 protein results in increased expression of UCP1 mRNA]	11742803
C009407	2,5,2',5'-tetrachlorobiphenyl	[2,4,4'-trichlorobiphenyl co-treated with 2,5,2',5'-tetrachlorobiphenyl co-treated with 2,4,5,2',5'-pentachlorobiphenyl co-treated with 2,2',3',4,4',5-hexachlorobiphenyl co-treated with 2,4,5,2',4',5'-hexachlorobiphenyl co-treated with PCB 180] results in decreased expression of FGF1 mRNA	25510870
C018855	2-tert-butylhydroquinone	2-tert-butylhydroquinone promotes the reaction [FGF1 protein results in increased abundance of and results in increased secretion of Glutathione]	16524372
C018855	2-tert-butylhydroquinone	FGF1 protein promotes the reaction [2-tert-butylhydroquinone results in increased expression of HMOX1 protein]	16524372
C028451	3,4,3',4'-tetrachlorobiphenyl	3,4,3',4'-tetrachlorobiphenyl inhibits the reaction [Dietary Fats results in increased expression of FGF1 mRNA]	19467301
C023035	3,4,5,3',4'-pentachlorobiphenyl	3,4,5,3',4'-pentachlorobiphenyl results in decreased expression of FGF1 mRNA	23196670
C459179	4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide	[NOG protein co-treated with Valproic Acid co-treated with dorsomorphin co-treated with 4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide] results in increased expression of FGF1 mRNA	27188386
C002202	4-oxoretinoic acid	4-oxoretinoic acid results in decreased expression of FGF1 mRNA	15982314
D000082	Acetaminophen	Acetaminophen affects the expression of FGF1 mRNA	17562736
D016604	Aflatoxin B1	Aflatoxin B1 affects the methylation of FGF1 intron	30157460
D016604	Aflatoxin B1	Aflatoxin B1 results in increased methylation of FGF1 gene	27153756
D016604	Aflatoxin B1	Aflatoxin B1 results in decreased expression of FGF1 mRNA	19770486
D016604	Aflatoxin B1	Aflatoxin B1 results in increased expression of FGF1 mRNA	23630614; 25378103;
C029753	aflatoxin B2	aflatoxin B2 results in increased methylation of FGF1 intron	30157460
C000593263	afuresertib	afuresertib results in decreased expression of FGF1 mRNA	28960945
D000077556	Alitretinoin	Alitretinoin results in decreased expression of FGF1 mRNA	15982314
C040534	alpha-hexachlorocyclohexane	alpha-hexachlorocyclohexane results in decreased susceptibility to FGF1 protein	1715812
C045742	amlexanox	amlexanox binds to and results in increased stability of and results in decreased secretion of FGF1 protein	16300395
C045742	amlexanox	[amlexanox binds to FGF1 protein] inhibits the reaction [cupric chloride results in increased oxidation of FGF1 protein]	16300395
C045742	amlexanox	amlexanox inhibits the reaction [FGF1 protein binds to FGF1 protein]	16300395
D000643	Ammonium Chloride	Ammonium Chloride affects the expression of FGF1 mRNA	16483693
D000968	Antimycin A	Antimycin A results in decreased expression of FGF1 mRNA	19304788
D001151	Arsenic	Arsenic affects the methylation of FGF1 gene	25304211
D000077237	Arsenic Trioxide	Arsenic Trioxide results in decreased expression of FGF1 mRNA	21461292
D001280	Atrazine	Atrazine results in increased expression of FGF1 mRNA	25929836
C547126	AZM551248	AZM551248 results in decreased expression of FGF1 mRNA	22323515
D001564	Benzo(a)pyrene	Benzo(a)pyrene affects the methylation of FGF1 intron	30157460
D001564	Benzo(a)pyrene	Benzo(a)pyrene results in decreased expression of FGF1 mRNA	19770486
D001564	Benzo(a)pyrene	Benzo(a)pyrene results in increased expression of FGF1 mRNA	22228805
C006703	benzo(b)fluoranthene	benzo(b)fluoranthene results in decreased expression of FGF1 mRNA	26377693
C026487	benzo(e)pyrene	benzo(e)pyrene results in increased methylation of FGF1 intron	30157460
C543008	bis(4-hydroxyphenyl)sulfone	bis(4-hydroxyphenyl)sulfone results in increased expression of FGF1 mRNA	27685785
C543008	bis(4-hydroxyphenyl)sulfone	bis(4-hydroxyphenyl)sulfone results in increased expression of FGF1 mRNA	30951980
C070515	bisindolylmaleimide I	bisindolylmaleimide I promotes the reaction [FGF1 protein results in increased expression of UCP1 mRNA]	11742803
C006780	bisphenol A	bisphenol A results in decreased expression of FGF1 mRNA	29275510
C006780	bisphenol A	bisphenol A results in decreased expression of FGF1 mRNA	21932408
C006780	bisphenol A	bisphenol A results in increased expression of FGF1 mRNA	27022677; 30951980;
C006780	bisphenol A	[bisphenol A co-treated with Estradiol] results in decreased expression of FGF1 mRNA	26496021
C006780	bisphenol A	bisphenol A results in decreased expression of FGF1 mRNA	25181051
C000611646	bisphenol F	bisphenol F results in increased expression of FGF1 mRNA	30951980
C018475	butyraldehyde	butyraldehyde results in increased expression of FGF1 mRNA	26079696
D002104	Cadmium	Cadmium results in decreased expression of FGF1 mRNA	20570719
D002104	Cadmium	Cadmium results in increased expression of FGF1 mRNA	20570719
D000001	Calcimycin	Calcimycin results in increased expression of FGF1 protein	15264218
D002118	Calcium	Calcium results in increased expression of FGF1 protein	15264218
D002217	Carbachol	Carbachol results in increased expression of FGF1 protein	15264218
D002217	Carbachol	KT 5720 inhibits the reaction [Norepinephrine inhibits the reaction [Carbachol results in increased expression of FGF1 protein]]	15264218
D002217	Carbachol	Norepinephrine inhibits the reaction [Carbachol results in increased expression of FGF1 protein]	15264218
D002251	Carbon Tetrachloride	Carbon Tetrachloride results in decreased expression of FGF1 mRNA	17484886; 27339419;
D002251	Carbon Tetrachloride	FGF1 protein affects the susceptibility to Carbon Tetrachloride	14507672
D002251	Carbon Tetrachloride	Carbon Tetrachloride results in decreased expression of FGF1 mRNA	31150632
D002251	Carbon Tetrachloride	schizandrin B inhibits the reaction [Carbon Tetrachloride results in decreased expression of FGF1 mRNA]	31150632
D002726	Chlorogenic Acid	Chlorogenic Acid results in increased expression of FGF1 mRNA	20706672
D004390	Chlorpyrifos	Chlorpyrifos affects the expression of FGF1 mRNA	18502319
D002945	Cisplatin	[Cisplatin co-treated with jinfukang] results in decreased expression of FGF1 mRNA	27392435
D002945	Cisplatin	Cisplatin results in decreased expression of FGF1 mRNA	27392435
D002945	Cisplatin	Cisplatin results in decreased expression of FGF1 mRNA	22023808
D002994	Clofibrate	Clofibrate results in decreased expression of FGF1 mRNA	17585979
D003008	Cloprostenol	Cloprostenol results in increased expression of FGF1 mRNA	14991729
C018021	cobaltous chloride	cobaltous chloride results in decreased expression of FGF1 mRNA	24386269
D003300	Copper	Copper affects the secretion of [FGF1 protein binds to SYT1 protein binds to S100A13 protein]	16262243
C029892	cupric chloride	[amlexanox binds to FGF1 protein] inhibits the reaction [cupric chloride results in increased oxidation of FGF1 protein]	16300395
D016572	Cyclosporine	Cyclosporine results in decreased expression of FGF1 mRNA	27989131
D016572	Cyclosporine	Cyclosporine results in decreased expression of FGF1 mRNA	19770486
C093628	cyproconazole	cyproconazole results in decreased expression of FGF1 mRNA	22334560
D003976	Diazinon	Diazinon results in increased methylation of FGF1 gene	22964155
D003976	Diazinon	Diazinon affects the expression of FGF1 mRNA	22546817
D003976	Diazinon	Diazinon results in decreased expression of FGF1 mRNA	19130878
D004008	Diclofenac	Diclofenac results in decreased expression of FGF1 mRNA	26934552
D004026	Dieldrin	Dieldrin affects the expression of FGF1 mRNA	19130878; 22546817;
D004041	Dietary Fats	3,4,3',4'-tetrachlorobiphenyl inhibits the reaction [Dietary Fats results in increased expression of FGF1 mRNA]	19467301
D004041	Dietary Fats	Dietary Fats affects the expression of FGF1 mRNA	19680557
D004041	Dietary Fats	Dietary Fats results in increased expression of FGF1 mRNA	18042831; 19030233; 19467301;
D004041	Dietary Fats	Rimonabant inhibits the reaction [Dietary Fats results in increased expression of FGF1 mRNA]	19030233
D004051	Diethylhexyl Phthalate	Diethylhexyl Phthalate results in increased expression of FGF1 mRNA	31163220
D004052	Diethylnitrosamine	Diethylnitrosamine results in increased expression of FGF1 mRNA	18691550
D004052	Diethylnitrosamine	MAPK14 protein inhibits the reaction [Diethylnitrosamine results in increased expression of FGF1 mRNA]	18691550
D004052	Diethylnitrosamine	[Piperonyl Butoxide co-treated with Diethylnitrosamine] affects the methylation of FGF1 gene	23968726
D004052	Diethylnitrosamine	[indole-3-carbinol co-treated with Diethylnitrosamine] results in increased expression of FGF1 mRNA	22129741
D004237	Diuron	Diuron results in decreased expression of FGF1 mRNA	21551480
C516138	dorsomorphin	[NOG protein co-treated with Valproic Acid co-treated with dorsomorphin co-treated with 4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide] results in increased expression of FGF1 mRNA	27188386
D004317	Doxorubicin	[[MT1 protein co-treated with MT2 protein] affects the susceptibility to Doxorubicin] which affects the expression of FGF1 mRNA	21040762
D013759	Dronabinol	Dronabinol results in increased expression of FGF1 mRNA	17578508
D004726	Endosulfan	Endosulfan results in decreased expression of FGF1 mRNA	29391264
C044101	endotoxin, Escherichia coli	endotoxin, Escherichia coli results in increased expression of FGF1 mRNA	15919760
D017984	Enoxaparin	Enoxaparin results in increased activity of FGF1 protein	16260867
C045651	epigallocatechin gallate	epigallocatechin gallate results in decreased expression of FGF1 mRNA	20706672
C109476	epoxiconazole	epoxiconazole results in decreased expression of FGF1 mRNA	22334560
D004958	Estradiol	[Estradiol co-treated with TGFB1 protein] results in decreased expression of FGF1 mRNA	30165855
D004958	Estradiol	[bisphenol A co-treated with Estradiol] results in decreased expression of FGF1 mRNA	26496021
D000431	Ethanol	Ethanol results in increased expression of FGF1 mRNA	28789864
D000431	Ethanol	Ethanol affects the expression of FGF1 mRNA	30319688
D000431	Ethanol	Ethanol results in increased expression of FGF1 mRNA	30319688
D019856	Ethanolamine	Ethanolamine results in increased activity of FGF1 protein	15802876
D017313	Fenretinide	Fenretinide results in decreased expression of FGF1 mRNA	28973697
D017313	Fenretinide	Fenretinide results in increased expression of FGF1 mRNA	28973697
C082360	fipronil	fipronil results in increased expression of FGF1 mRNA	23962444
D005473	Fluoxetine	Fluoxetine results in increased expression of FGF1 mRNA	17033635
D005485	Flutamide	Flutamide results in decreased expression of FGF1 mRNA	24793618
C039281	furan	furan results in decreased expression of FGF1 mRNA	25539665
D005680	gamma-Aminobutyric Acid	gamma-Aminobutyric Acid results in increased expression of FGF1 protein	15264218
D019833	Genistein	Genistein results in decreased expression of FGF1 mRNA	20706672
D005978	Glutathione	2-tert-butylhydroquinone promotes the reaction [FGF1 protein results in increased abundance of and results in increased secretion of Glutathione]	16524372
D005978	Glutathione	FGF1 protein results in increased abundance of and results in increased secretion of Glutathione	16524372
D006046	Gold	[Gold co-treated with Polyethylene Glycols] results in increased expression of FGF1 mRNA	19695318
D019812	Heparan Sulfate Proteoglycans	Heparan Sulfate Proteoglycans binds to FGF1 protein	12512896
D019812	Heparan Sulfate Proteoglycans	Heparan Sulfate Proteoglycans promotes the reaction [FGF1 protein binds to and results in increased activity of FGFR1 protein]	15767480
D019812	Heparan Sulfate Proteoglycans	Heparan Sulfate Proteoglycans affects the reaction [FGF1 protein binds to FGFR1 protein]	10336501
D019812	Heparan Sulfate Proteoglycans	Heparan Sulfate Proteoglycans affects the reaction [FGF1 protein binds to FGFR4 protein]	10336501
D006493	Heparin	[Heparin analog binds to FGFR2 protein alternative form] which binds to and results in increased activity of FGF1 protein	16219767
D006493	Heparin	Heparin analog promotes the reaction [FGF1 protein binds to FGF1 protein]	16219767
D006493	Heparin	Heparin promotes the reaction [FGFR1 protein binds to FGF1 protein]	1379594
D006493	Heparin	Heparin promotes the reaction [FGFR3 protein binds to FGF1 protein]	1379594
D006493	Heparin	Heparin affects the reaction [FGF1 protein binds to FGFR4 protein]	10336501
D006493	Heparin	[Heparin binds to FGFR2 protein alternative form] which binds to FGF1 protein	10860838
D006493	Heparin	Heparin inhibits the reaction [FGF1 protein results in increased phosphorylation of AKT1 protein]	14966081
D006493	Heparin	Heparin inhibits the reaction [FGF1 protein results in increased phosphorylation of MAP2K1 protein]	14966081
D006493	Heparin	Heparin inhibits the reaction [FGF1 protein results in increased phosphorylation of MAP2K2 protein]	14966081
D006493	Heparin	Heparin inhibits the reaction [FGF1 protein results in increased phosphorylation of MAPK1 protein]	14966081
D006493	Heparin	Heparin inhibits the reaction [FGF1 protein results in increased phosphorylation of MAPK3 protein]	14966081
D006493	Heparin	Heparin promotes the reaction [FGF1 protein results in increased expression of FGF1 protein]	8576258
D006493	Heparin	FGF1 protein binds to FGFR2 protein binds to Heparin	15165853; 16223363;
D006493	Heparin	Heparin affects the activity of FGF1 protein	9174673
D006493	Heparin	Heparin analog binds to and results in decreased degradation of FGF1 protein	9174673
D006493	Heparin	Heparin binds to FGF1 protein	15632177
D006493	Heparin	phosphomannopentaose sulfate inhibits the reaction [Heparin binds to FGF1 protein]	15632177
D006497	Heparitin Sulfate	FGF1 protein binds to Heparitin Sulfate binds to FGFR1 protein	12604602
D006497	Heparitin Sulfate	Heparitin Sulfate analog binds to FGF1 protein	15081013
D006497	Heparitin Sulfate	Heparitin Sulfate analog promotes the reaction [FGF1 protein results in increased activity of FGFR2 protein alternative form]	11714710
D006632	Histamine	Histamine results in increased expression of FGF1 protein	15264218
D006861	Hydrogen Peroxide	FGF1 protein results in decreased susceptibility to Hydrogen Peroxide	16222742
C016517	indole-3-carbinol	indole-3-carbinol affects the expression of FGF1 mRNA	21396975
C016517	indole-3-carbinol	[indole-3-carbinol co-treated with Diethylnitrosamine] results in increased expression of FGF1 mRNA	22129741
C018086	isobutyl nitrite	isobutyl nitrite results in increased expression of FGF1 mRNA	16288974
D015474	Isotretinoin	Isotretinoin results in decreased expression of FGF1 mRNA	15982314
C544151	jinfukang	[Cisplatin co-treated with jinfukang] results in decreased expression of FGF1 mRNA	27392435
C544151	jinfukang	jinfukang results in decreased expression of FGF1 mRNA	27392435
C057416	KT 5720	KT 5720 inhibits the reaction [Norepinephrine inhibits the reaction [Carbachol results in increased expression of FGF1 protein]]	15264218
D007736	Kynurenic Acid	Kynurenic Acid results in decreased secretion of FGF1 protein	16392031
C008261	lead acetate	lead acetate affects the expression of FGF1 mRNA	21864555
C038753	leptomycin B	leptomycin B results in decreased localization of and results in increased phosphorylation of FGF1 protein	15574884
D008070	Lipopolysaccharides	Lipopolysaccharides results in increased expression of FGF1 mRNA	15919760
D058185	Magnetite Nanoparticles	[Succimer co-treated with Magnetite Nanoparticles] results in decreased expression of FGF1 mRNA	26378955
C015977	malealdehyde	FGF1 protein results in decreased secretion of malealdehyde	16222742
D008687	Metformin	Metformin inhibits the reaction [IL13 protein results in increased expression of FGF1 mRNA]	26497364
D008701	Methapyrilene	Methapyrilene results in increased methylation of FGF1 intron	30157460
D008727	Methotrexate	Methotrexate results in increased expression of FGF1 mRNA	19192274
D008727	Methotrexate	Methotrexate affects the expression of FGF1 mRNA	18502557
D008748	Methylcholanthrene	[Methylcholanthrene co-treated with Tetradecanoylphorbol Acetate] results in increased expression of FGF1 mRNA	23519560
D008770	Methylnitrosourea	FGF1 protein modified form inhibits the reaction [Methylnitrosourea results in decreased expression of BCL2 protein]	16011256
D008770	Methylnitrosourea	FGF1 protein modified form inhibits the reaction [Methylnitrosourea results in increased expression of BAX protein]	16011256
C056218	ML 9	ML 9 inhibits the reaction [FGF1 protein alternative form results in increased phosphorylation of AKT3 protein]	15517595
D037742	Nanotubes, Carbon	Nanotubes, Carbon analog results in decreased expression of FGF1 mRNA	25554681
D037742	Nanotubes, Carbon	Nanotubes, Carbon results in decreased expression of FGF1 mRNA	25554681
D009532	Nickel	Nickel results in decreased expression of FGF1 mRNA	24768652; 25583101;
D009532	Nickel	Nickel results in decreased expression of FGF1 mRNA	12540486
D009532	Nickel	Nickel results in decreased expression of FGF1 mRNA	19130878
C022838	nickel chloride	nickel chloride affects the expression of FGF1 mRNA	22546817
C029938	nickel sulfate	nickel sulfate results in decreased expression of FGF1 mRNA	22714537
D009534	Niclosamide	Niclosamide results in decreased expression of FGF1 mRNA	25174399
D009534	Niclosamide	Niclosamide results in decreased expression of FGF1 protein	25174399
D009569	Nitric Oxide	FGF1 protein results in increased abundance of Nitric Oxide	16524372
D009569	Nitric Oxide	PD 166866 inhibits the reaction [FGF1 protein results in increased abundance of Nitric Oxide]	16524372
D009638	Norepinephrine	[AVP protein co-treated with Norepinephrine] inhibits the reaction [Triiodothyronine promotes the reaction [FGF1 protein results in increased expression of UCP1 mRNA]]	11742803
D009638	Norepinephrine	[FGF1 protein co-treated with AVP protein co-treated with Norepinephrine co-treated with Triiodothyronine] results in decreased expression of UCP1 mRNA	11742803
D009638	Norepinephrine	KT 5720 inhibits the reaction [Norepinephrine inhibits the reaction [Carbachol results in increased expression of FGF1 protein]]	15264218
D009638	Norepinephrine	Norepinephrine inhibits the reaction [Carbachol results in increased expression of FGF1 protein]	15264218
C558013	NSC 689534	NSC 689534 results in increased expression of FGF1 mRNA	20971185
D009844	Oligosaccharides	Oligosaccharides binds to and results in decreased degradation of FGF1 protein	9174673
D009844	Oligosaccharides	Oligosaccharides promotes the reaction [FGF1 protein binds to and results in increased activity of FGFR1 protein]	11714710
D009844	Oligosaccharides	Oligosaccharides promotes the reaction [FGF1 protein binds to FGFR1 protein alternative form]	9174673
D009844	Oligosaccharides	Oligosaccharides promotes the reaction [FGF1 protein binds to FGFR4 protein]	11714710; 9174673;
D009844	Oligosaccharides	Oligosaccharides promotes the reaction [FGF1 protein results in increased activity of FGFR2 protein alternative form]	11714710
C412603	orantinib	orantinib results in decreased activity of FGF1 protein	15739567
C485800	osajin	osajin results in increased expression of FGF1 mRNA	20706672
D010100	Oxygen	[NFE2L2 protein affects the susceptibility to Oxygen] which affects the expression of FGF1 mRNA	30529165
D000073878	Palm Oil	Palm Oil affects the expression of FGF1 mRNA	19680557
D000073878	Palm Oil	Palm Oil results in increased expression of FGF1 mRNA	18042831
D010269	Paraquat	Paraquat results in increased expression of FGF1 mRNA	16324872
D052638	Particulate Matter	Particulate Matter results in decreased expression of FGF1 mRNA	29703138
C410127	PCB 180	[2,4,4'-trichlorobiphenyl co-treated with 2,5,2',5'-tetrachlorobiphenyl co-treated with 2,4,5,2',5'-pentachlorobiphenyl co-treated with 2,2',3',4,4',5-hexachlorobiphenyl co-treated with 2,4,5,2',4',5'-hexachlorobiphenyl co-treated with PCB 180] results in decreased expression of FGF1 mRNA	25510870
C113399	PD 166866	PD 166866 inhibits the reaction [FGF1 protein results in increased abundance of Nitric Oxide]	16524372
C113399	PD 166866	PD 166866 inhibits the reaction [FGF1 protein results in increased expression of and results in increased secretion of NGF protein]	15773903
C113399	PD 166866	PD 166866 inhibits the reaction [FGF1 protein results in increased expression of FGFR1 protein]	15773903
C113399	PD 166866	PD 166866 inhibits the reaction [FGF1 protein results in increased expression of NOS2 mRNA]	16524372
C113399	PD 166866	PD 166866 inhibits the reaction [FGF1 protein results in increased expression of POSTN mRNA]	15121739
C115711	PD 173074	PD 173074 inhibits the reaction [FGF1 protein results in increased phosphorylation of FGFR4 protein]	15709206
D010634	Phenobarbital	Phenobarbital affects the expression of FGF1 mRNA	23091169
D010634	Phenobarbital	Phenobarbital results in decreased susceptibility to FGF1 protein	1715812
D010634	Phenobarbital	Phenobarbital results in increased expression of FGF1 mRNA	19162173
C120158	phosphomannopentaose sulfate	phosphomannopentaose sulfate analog binds to FGF1 protein	16366604
C120158	phosphomannopentaose sulfate	phosphomannopentaose sulfate binds to FGF1 protein	16366604
C120158	phosphomannopentaose sulfate	phosphomannopentaose sulfate inhibits the reaction [Heparin binds to FGF1 protein]	15632177
D010882	Piperonyl Butoxide	[Piperonyl Butoxide co-treated with Diethylnitrosamine] affects the methylation of FGF1 gene	23968726
C006253	pirinixic acid	[pirinixic acid binds to and results in increased activity of PPARA protein] which results in increased expression of FGF1 mRNA	19710929
C006253	pirinixic acid	pirinixic acid results in increased expression of FGF1 mRNA	17426115; 18301758; 18445702;
D028321	Plant Preparations	Plant Preparations results in increased expression of FGF1 mRNA	26945725
D011092	Polyethylene Glycols	[Gold co-treated with Polyethylene Glycols] results in increased expression of FGF1 mRNA	19695318
C474837	pomiferin	pomiferin results in increased expression of FGF1 mRNA	20706672
D011189	Potassium Chloride	Potassium Chloride results in increased expression of FGF1 protein	15264218
D011192	Potassium Dichromate	Potassium Dichromate results in decreased expression of FGF1 mRNA	23608068
D011285	Pregnenolone Carbonitrile	Pregnenolone Carbonitrile results in increased expression of FGF1 mRNA	28903501
D011285	Pregnenolone Carbonitrile	Pregnenolone Carbonitrile results in increased expression of FGF1 mRNA	19162173
C045950	propiconazole	propiconazole results in decreased expression of FGF1 mRNA	22334560
D011433	Propranolol	Propranolol results in increased expression of FGF1 mRNA	15264218
D011441	Propylthiouracil	Propylthiouracil results in decreased expression of FGF1 mRNA	24780913
C033607	puerarin	puerarin results in increased expression of FGF1 mRNA	20706672
C432165	pyrazolanthrone	pyrazolanthrone inhibits the reaction [FGF1 protein results in increased expression of SPP1 mRNA]	15121739
D011794	Quercetin	Quercetin results in decreased expression of FGF1 protein	28431985
D017378	Quinolinic Acid	Quinolinic Acid results in decreased secretion of FGF1 protein	16392031
D000077185	Resveratrol	Resveratrol results in increased expression of FGF1 mRNA	20706672
D000077285	Rimonabant	Rimonabant affects the expression of FGF1 mRNA	19030233
D000077285	Rimonabant	Rimonabant inhibits the reaction [Dietary Fats results in increased expression of FGF1 mRNA]	19030233
C529148	rosavin	rosavin results in increased expression of FGF1 mRNA	20706672
D012402	Rotenone	Rotenone results in decreased expression of FGF1 mRNA	19304788
C085746	rottlerin	rottlerin inhibits the reaction [PRKCD protein results in increased phosphorylation of FGF1 protein]	15574884
C093642	SB 203580	SB 203580 inhibits the reaction [FGF1 protein results in increased expression of POSTN mRNA]	15121739
C015499	schizandrin B	schizandrin B inhibits the reaction [Carbon Tetrachloride results in decreased expression of FGF1 mRNA]	31150632
D012701	Serotonin	Serotonin results in increased expression of FGF1 protein	15264218
D000068677	Sildenafil Citrate	Sildenafil Citrate results in increased expression of FGF1 mRNA	20583517
D012822	Silicon Dioxide	Silicon Dioxide analog results in increased expression of FGF1 mRNA	25895662
D020123	Sirolimus	Sirolimus inhibits the reaction [FGF1 protein results in increased expression of POSTN mRNA]	15121739
C041711	St. Thomas' Hospital cardioplegic solution	St. Thomas' Hospital cardioplegic solution results in increased expression of FGF1 mRNA	16214533
C105686	SU 5402	SU 5402 inhibits the reaction [FGF1 protein results in increased activity of FGFR3 protein]	14871245
C105686	SU 5402	SU 5402 results in decreased expression of FGF1 mRNA	12421715
D004113	Succimer	[Succimer co-treated with Magnetite Nanoparticles] results in decreased expression of FGF1 mRNA	26378955
D013605	T-2 Toxin	T-2 Toxin results in decreased expression of FGF1 mRNA	31299295
C013698	tallow	tallow affects the expression of FGF1 mRNA	19680557
C020806	tetrabromobisphenol A	tetrabromobisphenol A results in increased expression of FGF1 mRNA	25172293
D013749	Tetrachlorodibenzodioxin	Tetrachlorodibenzodioxin results in decreased expression of FGF1 mRNA	21296121
D013749	Tetrachlorodibenzodioxin	Tetrachlorodibenzodioxin affects the expression of FGF1 mRNA	21570461; 26377647;
D013749	Tetrachlorodibenzodioxin	Tetrachlorodibenzodioxin results in decreased expression of FGF1 mRNA	19770486; 24035824; 26290441;
D013749	Tetrachlorodibenzodioxin	Tetrachlorodibenzodioxin affects the expression of FGF1 mRNA	22298810
D013755	Tetradecanoylphorbol Acetate	[Methylcholanthrene co-treated with Tetradecanoylphorbol Acetate] results in increased expression of FGF1 mRNA	23519560
C020809	tetrathiomolybdate	tetrathiomolybdate results in decreased secretion of FGF1 protein	18400376
D013792	Thalidomide	Thalidomide results in decreased expression of FGF1 mRNA	30834740
D013853	Thioacetamide	Thioacetamide results in increased expression of FGF1 mRNA	23411599
D013974	Thyroxine	Thyroxine results in increased expression of FGF1 mRNA	23935926
C016151	tinuvin	tinuvin analog results in decreased expression of FGF1 mRNA	30315675
C009495	titanium dioxide	titanium dioxide affects the expression of FGF1 mRNA	17656681
C009495	titanium dioxide	titanium dioxide results in decreased expression of FGF1 mRNA	23557971
D014028	Tobacco Smoke Pollution	Tobacco Smoke Pollution results in decreased expression of FGF1 mRNA	30659203
D024505	Tocopherols	Tocopherols results in decreased expression of FGF1 mRNA	15878867
D014212	Tretinoin	Tretinoin metabolite results in decreased expression of FGF1 mRNA	15982314
D014212	Tretinoin	Tretinoin results in decreased expression of FGF1 mRNA	15982314
D014284	Triiodothyronine	[AVP protein co-treated with Norepinephrine] inhibits the reaction [Triiodothyronine promotes the reaction [FGF1 protein results in increased expression of UCP1 mRNA]]	11742803
D014284	Triiodothyronine	AVP protein inhibits the reaction [Triiodothyronine promotes the reaction [FGF1 protein results in increased expression of UCP1 mRNA]]	11742803
D014284	Triiodothyronine	[FGF1 protein co-treated with AVP protein co-treated with Norepinephrine co-treated with Triiodothyronine] results in decreased expression of UCP1 mRNA	11742803
D014284	Triiodothyronine	Triiodothyronine promotes the reaction [FGF1 protein results in increased expression of UCP1 mRNA]	11742803
C113580	U 0126	FGF1 protein inhibits the reaction [U 0126 results in decreased phosphorylation of and results in decreased activity of MAPK1 protein]	15231676
C113580	U 0126	FGF1 protein inhibits the reaction [U 0126 results in decreased phosphorylation of and results in decreased activity of MAPK3 protein]	15231676
C113580	U 0126	U 0126 inhibits the reaction [FGF1 protein results in increased expression of POSTN mRNA]	15121739
C113580	U 0126	U 0126 inhibits the reaction [FGF1 protein results in increased expression of SPP1 mRNA]	15121739
D014635	Valproic Acid	[NOG protein co-treated with Valproic Acid co-treated with dorsomorphin co-treated with 4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide] results in increased expression of FGF1 mRNA	27188386
D014635	Valproic Acid	Valproic Acid results in decreased expression of FGF1 mRNA	29154799
D014635	Valproic Acid	Valproic Acid affects the expression of FGF1 mRNA	17292431
D001335	Vehicle Emissions	Vehicle Emissions affects the methylation of FGF1 gene	25560391
C025643	vinclozolin	vinclozolin affects the expression of FGF1 mRNA	19015723
C029297	vinylidene chloride	vinylidene chloride results in decreased expression of FGF1 mRNA	26682919
D000077191	Wortmannin	Wortmannin results in decreased activity of FGF1 protein	15695173
D000077191	Wortmannin	Wortmannin inhibits the reaction [FGF1 protein results in increased expression of POSTN mRNA]	15121739
D015032	Zinc	Zinc results in increased expression of FGF1 mRNA	17074742
D019287	Zinc Sulfate	Zinc Sulfate results in increased expression of FGF1 mRNA	17074742

Functional annotations

Keywords

Keyword ID	Keyword Term
KW-0002	3D-structure
KW-0007	Acetylation
KW-0025	Alternative splicing
KW-0037	Angiogenesis
KW-0963	Cytoplasm
KW-0217	Developmental protein
KW-0221	Differentiation
KW-0903	Direct protein sequencing
KW-0339	Growth factor
KW-0358	Heparin-binding
KW-0497	Mitogen
KW-0539	Nucleus
KW-0597	Phosphoprotein
KW-0621	Polymorphism
KW-1185	Reference proteome
KW-0964	Secreted

Interpro

InterPro ID	InterPro Term
IPR028210	FGF1
IPR002209	Fibroblast_GF_fam
IPR008996	IL1/FGF

PROSITE

PROSITE ID	PROSITE Term
PS00247	HBGF_FGF

Pfam

Pfam ID	Pfam Term
PF00167	FGF

Gene: FGF1

Basic information

Gene expression information

Gene expression in different tissues (GTEx V7)

Gene expression in different tissues (ENCODE)

Protein structural annotations

3D structure in PDB database

Protein disorder information

Orthologous information

Identified variants/mutations related to cleft phenotype

Other genetic variants/mutations

Disease or phenotype associated information

Gene Ontology (GO)/biological pathways

GO:Molecular Function

GO:Biological Process

GO:Cellular Component

Reactome Pathway

Drugs and compounds information

Functional annotations

Keywords

Interpro

PROSITE

Pfam

Protein-protein interaction

Protein-miRNA interaction