Gene: GREM1

Basic information

Tag Content
Uniprot ID A0A287ABW3
Entrez ID
Genbank protein ID
Genbank nucleotide ID XM_005659770.2
Ensembl protein ID ENSSSCP00000041370
Ensembl nucleotide ID ENSSSCG00000033657
Gene name Gremlin
Gene symbol GREM1
Organism Sus scrofa
NCBI taxa ID 9823
Cleft type
Developmental stage
Data sources Homology search
Reference
Functional description
Sequence
MSRTAYTVGA LLLLLGTLLP AAEGKKKGSQ GAIPPPDKAQ HNDSEQTQSP QQPGSRNRGR 60
GQGRGTAMPG EEVLESSQEA LHVTERKYLK RDWCKTQPLK QTIHEEGCNS RTIINRFCYG 120
QCNSFYIPRH IRKEEGSFQS CSFCKPKKFT TMMVTLNCPE LQPPTKKKRV TRVKQCRCIS 180
IDLD 184

Abbreviation :
CLO : cleft lip only. CPO : cleft palate only. CLP : cleft lip and palate. CL/P : cleft lip with/without cleft palate.
For humans: CL/P, CLO, CPO, and CLP. For mice: CLO, CLP, and CPO.

Protein disorder information

Orthologous information

Relation Gene symbol Entrez ID UniProt ID Cleft type Developmental stage Species Evidence Details
1:1 orthologGREM1539079A2VE87Bos taurusPredictionMore>>
1:1 orthologGREM1A0A452E4N7Capra hircusPredictionMore>>
1:1 orthologGREM126585O60565CL/PHomo sapiensPublicationMore>>
1:1 orthologGrem123892O70326Mus musculusPredictionMore>>
1:1 orthologGREM1A0A287ABW3Sus scrofaPredictionMore>>
1:1 orthologGREM1100342066G1TUM4Oryctolagus cuniculusPredictionMore>>
1:1 orthologGrem150566O35793Rattus norvegicusPredictionMore>>
1:1 orthologgrem1bA0A0R4IYE7Danio rerioPredictionMore>>

Gene ontology

GO ID GO Term
GO:0009986 cell surface
GO:0005615 extracellular space
GO:0036122 BMP binding
GO:0005125 cytokine activity
GO:0042803 protein homodimerization activity
GO:0030297 transmembrane receptor protein tyrosine kinase activator activity
GO:0043184 vascular endothelial growth factor receptor 2 binding
GO:0002042 cell migration involved in sprouting angiogenesis
GO:0000902 cell morphogenesis
GO:0007267 cell-cell signaling
GO:0030199 collagen fibril organization
GO:0048263 determination of dorsal identity
GO:0030326 embryonic limb morphogenesis
GO:0003337 mesenchymal to epithelial transition involved in metanephros morphogenesis
GO:0043066 negative regulation of apoptotic process
GO:0030514 negative regulation of BMP signaling pathway
GO:1900158 negative regulation of bone mineralization involved in bone maturation
GO:0046851 negative regulation of bone remodeling
GO:1900155 negative regulation of bone trabecula formation
GO:0090090 negative regulation of canonical Wnt signaling pathway
GO:0032331 negative regulation of chondrocyte differentiation
GO:0045668 negative regulation of osteoblast differentiation
GO:0033689 negative regulation of osteoblast proliferation
GO:0090291 negative regulation of osteoclast proliferation
GO:0060394 negative regulation of pathway-restricted SMAD protein phosphorylation
GO:0045892 negative regulation of transcription, DNA-templated
GO:0045766 positive regulation of angiogenesis
GO:0090190 positive regulation of branching involved in ureteric bud morphogenesis
GO:2000727 positive regulation of cardiac muscle cell differentiation
GO:0008284 positive regulation of cell population proliferation
GO:0051092 positive regulation of NF-kappaB transcription factor activity
GO:1901224 positive regulation of NIK/NF-kappaB signaling
GO:1900086 positive regulation of peptidyl-tyrosine autophosphorylation
GO:0002092 positive regulation of receptor internalization
GO:2000273 positive regulation of signaling receptor activity
GO:0051973 positive regulation of telomerase activity
GO:0003257 positive regulation of transcription from RNA polymerase II promoter involved in myocardial precursor cell differentiation
GO:0009954 proximal/distal pattern formation
GO:0010717 regulation of epithelial to mesenchymal transition
GO:0051893 regulation of focal adhesion assembly
GO:0060676 ureteric bud formation

Functional annotations

Keywords

Keyword ID Keyword Term
KW-0202 Cytokine
KW-1185 Reference proteome
KW-0964 Secreted
KW-0732 Signal

Interpro

InterPro ID InterPro Term
IPR006207 Cys_knot_C
IPR029034 Cystine-knot_cytokine
IPR004133 DAN
IPR017159 Gremlin-1/2

PROSITE

PROSITE ID PROSITE Term

Pfam

Pfam ID Pfam Term
PF03045 DAN