| Tag | Content |
|---|---|
| Uniprot ID | O35793 |
| Entrez ID | 50566 |
| Genbank protein ID | CAA71126.1 |
| Genbank nucleotide ID | NM_019282.3 |
| Ensembl protein ID | ENSRNOP00000035888 |
| Ensembl nucleotide ID | ENSRNOG00000026053 |
| Gene name | Gremlin-1 |
| Gene symbol | Grem1 |
| Organism | Rattus norvegicus |
| NCBI taxa ID | 10116 |
| Cleft type | |
| Developmental stage | |
| Data sources | Homology search |
| Reference | |
| Functional description | Cytokine that may play an important role during carcinogenesis and metanephric kidney organogenesis, as a BMP antagonist required for early limb outgrowth and patterning in maintaining the FGF4-SHH feedback loop. Down-regulates the BMP4 signaling in a dose-dependent manner (By similarity). Antagonist of BMP2; inhibits BMP2-mediated differentiation of osteoblasts (in vitro) (By similarity). Acts as inhibitor of monocyte chemotaxis (PubMed:15528323). Can inhibit the growth or viability of normal cells but not transformed cells when is overexpressed. |
| Sequence | MNRTAYTVGA LLLLLGTLLP AAEGKKKGSQ GAIPPPDKAQ HNDSEQTQSP PQPGSRTRGR 60 GQGRGTAMPG EEVLESSQEA LHVTERKYLK RDWCKTQPLK QTIHEEGCNS RTIINRFCYG 120 QCNSFYIPRH IRKEEGSFQS CSFCKPKKFT TMMVTLNCPE LQPPTKKKRV TRVKQCRCIS 180 IDLD 184 |
Abbreviation :
CLO : cleft lip only. CPO : cleft palate only.
CLP : cleft lip and palate. CL/P : cleft lip with/without cleft palate.
For humans: CL/P, CLO, CPO, and CLP. For mice: CLO, CLP, and CPO.
| Relation | Gene symbol | Entrez ID | UniProt ID | Cleft type | Developmental stage | Species | Evidence | Details |
|---|---|---|---|---|---|---|---|---|
| 1:1 ortholog | GREM1 | 539079 | A2VE87 | Bos taurus | Prediction | More>> | ||
| 1:1 ortholog | GREM1 | A0A452E4N7 | Capra hircus | Prediction | More>> | |||
| 1:1 ortholog | GREM1 | 26585 | O60565 | CL/P | Homo sapiens | Publication | More>> | |
| 1:1 ortholog | Grem1 | 23892 | O70326 | Mus musculus | Prediction | More>> | ||
| 1:1 ortholog | GREM1 | A0A287ABW3 | Sus scrofa | Prediction | More>> | |||
| 1:1 ortholog | GREM1 | 100342066 | G1TUM4 | Oryctolagus cuniculus | Prediction | More>> | ||
| 1:1 ortholog | Grem1 | 50566 | O35793 | Rattus norvegicus | Prediction | More>> | ||
| 1:1 ortholog | grem1b | A0A0R4IYE7 | Danio rerio | Prediction | More>> |
| GO ID | GO Term |
|---|---|
| GO:0009986 | cell surface |
| GO:0005615 | extracellular space |
| GO:0036122 | BMP binding |
| GO:0005125 | cytokine activity |
| GO:0042803 | protein homodimerization activity |
| GO:0048018 | receptor ligand activity |
| GO:0030297 | transmembrane receptor protein tyrosine kinase activator activity |
| GO:0043184 | vascular endothelial growth factor receptor 2 binding |
| GO:0001525 | angiogenesis |
| GO:0009887 | animal organ morphogenesis |
| GO:0006915 | apoptotic process |
| GO:0002042 | cell migration involved in sprouting angiogenesis |
| GO:0000902 | cell morphogenesis |
| GO:0007267 | cell-cell signaling |
| GO:0030199 | collagen fibril organization |
| GO:0048263 | determination of dorsal identity |
| GO:0030326 | embryonic limb morphogenesis |
| GO:0043542 | endothelial cell migration |
| GO:0060173 | limb development |
| GO:0003337 | mesenchymal to epithelial transition involved in metanephros morphogenesis |
| GO:0043066 | negative regulation of apoptotic process |
| GO:0030514 | negative regulation of BMP signaling pathway |
| GO:0030502 | negative regulation of bone mineralization |
| GO:1900158 | negative regulation of bone mineralization involved in bone maturation |
| GO:0046851 | negative regulation of bone remodeling |
| GO:1900155 | negative regulation of bone trabecula formation |
| GO:0090090 | negative regulation of canonical Wnt signaling pathway |
| GO:0030308 | negative regulation of cell growth |
| GO:0032331 | negative regulation of chondrocyte differentiation |
| GO:0002689 | negative regulation of leukocyte chemotaxis |
| GO:0090027 | negative regulation of monocyte chemotaxis |
| GO:0045668 | negative regulation of osteoblast differentiation |
| GO:0033689 | negative regulation of osteoblast proliferation |
| GO:0090291 | negative regulation of osteoclast proliferation |
| GO:0060394 | negative regulation of pathway-restricted SMAD protein phosphorylation |
| GO:0045892 | negative regulation of transcription, DNA-templated |
| GO:0045766 | positive regulation of angiogenesis |
| GO:0090190 | positive regulation of branching involved in ureteric bud morphogenesis |
| GO:2000727 | positive regulation of cardiac muscle cell differentiation |
| GO:0008284 | positive regulation of cell population proliferation |
| GO:0051092 | positive regulation of NF-kappaB transcription factor activity |
| GO:1901224 | positive regulation of NIK/NF-kappaB signaling |
| GO:1900086 | positive regulation of peptidyl-tyrosine autophosphorylation |
| GO:0061098 | positive regulation of protein tyrosine kinase activity |
| GO:0002092 | positive regulation of receptor internalization |
| GO:2000273 | positive regulation of signaling receptor activity |
| GO:0051973 | positive regulation of telomerase activity |
| GO:0045944 | positive regulation of transcription by RNA polymerase II |
| GO:0003257 | positive regulation of transcription from RNA polymerase II promoter involved in myocardial precursor cell differentiation |
| GO:0045893 | positive regulation of transcription, DNA-templated |
| GO:0009954 | proximal/distal pattern formation |
| GO:0010717 | regulation of epithelial to mesenchymal transition |
| GO:0051893 | regulation of focal adhesion assembly |
| GO:0007165 | signal transduction |
| GO:0060676 | ureteric bud formation |
| Pfam ID | Pfam Term |
|---|---|
| PF03045 | DAN |