Gene: MMP16

Basic information

Tag Content
Uniprot ID A0A2I3SEA5
Entrez ID
Genbank protein ID
Genbank nucleotide ID
Ensembl protein ID ENSPTRP00000075323
Ensembl nucleotide ID ENSPTRG00000020403
Gene name Matrix metallopeptidase 16
Gene symbol MMP16
Organism Pan troglodytes
NCBI taxa ID 9598
Cleft type
Developmental stage
Data sources Homology search
Reference
Functional description
Sequence
MILLTFSTGR RLDFVHHSGV FFLQTLLWIL CATVCGTEQY FNVEVWLQKY GYLPPTDPRM 60
SVLRSAETMQ SALAAMQQFY GINMTGKVDR NTIDWMKKPR CGVPDQTRGS SKFHIRRKRY 120
ALTGQKWQHK HITYSIKNVT PKVGDPETRK AIRRAFDVWQ NVTPLTFEEV PYSELENGKR 180
DVDITIIFAS GFHGDSSPFD GEGGFLAHAY FPGPGIGGDT HFDSDEPWTL GNPNHDGNDL 240
FLVAVHELGH ALGLEHSNDP TAIMAPFYQY METDNFKLPN DDLQGIQKIY GPPDKIPPPT 300
RPLPTVPPHR SIPPADPRKN DRPKPPRPPT GRPSYPGAKP NICDGNFNTL AILRREMFVF 360
KDQWFWRVRN NRVMDGYPMQ ITYFWLGLPP SIDAVYENSD GNFVFFKGNK YWVFKDTTLQ 420
PGYPHDLITL GSGIPPHGID SAIWWEDVGK TYFFKGDRYW RYSEEMKTMD PGYPKPITVW 480
KGIPESPQGA FVHKENGFTY FYKGKEYWKF NNQILKVEPG YPRSILKDFM GCDGPTDRVK 540
EGHSPPDDVD IVIKLDNTAS TVKAIAIVIP CILALCLLVL VYTVFQFKRK GTPRHILYCK 600
RSMQEEKRV 609

Abbreviation :
CLO : cleft lip only. CPO : cleft palate only. CLP : cleft lip and palate. CL/P : cleft lip with/without cleft palate.
For humans: CL/P, CLO, CPO, and CLP. For mice: CLO, CLP, and CPO.

Protein disorder information

Orthologous information

Relation Gene symbol Entrez ID UniProt ID Cleft type Developmental stage Species Evidence Details
1:1 orthologMMP16282886F1N797Bos taurusPredictionMore>>
1:1 orthologMMP16487036F1PLV8Canis lupus familiarisPredictionMore>>
1:1 orthologMMP16A0A452EG47Capra hircusPredictionMore>>
1:1 orthologMMP164325P51512Homo sapiensPredictionMore>>
1:1 orthologMmp1617389Q9WTR0CPOMus musculusPublicationMore>>
1:1 orthologMMP16A0A2I3SEA5Pan troglodytesPredictionMore>>
1:1 orthologMMP16100153257A0A287AKC1Sus scrofaPredictionMore>>
1:1 orthologMMP16100101605G1T0W4Oryctolagus cuniculusPredictionMore>>
1:1 orthologMmp16F1M7F5Rattus norvegicusPredictionMore>>

Gene ontology

GO ID GO Term
GO:0031012 extracellular matrix
GO:0005615 extracellular space
GO:0005887 integral component of plasma membrane
GO:0070006 metalloaminopeptidase activity
GO:0004222 metalloendopeptidase activity
GO:0008270 zinc ion binding
GO:0035988 chondrocyte proliferation
GO:0030574 collagen catabolic process
GO:0097094 craniofacial suture morphogenesis
GO:0048701 embryonic cranial skeleton morphogenesis
GO:0001958 endochondral ossification
GO:0030198 extracellular matrix organization
GO:0016485 protein processing
GO:0001501 skeletal system development

Functional annotations

Keywords

Keyword ID Keyword Term
KW-0106 Calcium
KW-1015 Disulfide bond
KW-0378 Hydrolase
KW-0472 Membrane
KW-0479 Metal-binding
KW-0482 Metalloprotease
KW-0645 Protease
KW-1185 Reference proteome
KW-0677 Repeat
KW-0812 Transmembrane
KW-1133 Transmembrane helix
KW-0862 Zinc

Interpro

InterPro ID InterPro Term
IPR000585 Hemopexin-like_dom
IPR036375 Hemopexin-like_dom_sf
IPR018487 Hemopexin-like_repeat
IPR018486 Hemopexin_CS
IPR033739 M10A_MMP
IPR024079 MetalloPept_cat_dom_sf
IPR028697 MMP16
IPR001818 Pept_M10_metallopeptidase
IPR021190 Pept_M10A
IPR021805 Pept_M10A_metallopeptidase_C
IPR021158 Pept_M10A_Zn_BS
IPR006026 Peptidase_Metallo
IPR002477 Peptidoglycan-bd-like
IPR036365 PGBD-like_sf

PROSITE

PROSITE ID PROSITE Term
PS00546 CYSTEINE_SWITCH
PS00024 HEMOPEXIN
PS51642 HEMOPEXIN_2

Pfam

Pfam ID Pfam Term
PF11857 DUF3377
PF00045 Hemopexin
PF00413 Peptidase_M10
PF01471 PG_binding_1