| Tag | Content |
|---|---|
| Uniprot ID | Q9WTR0; Q6PEQ6; Q9ERT6; |
| Entrez ID | 17389 |
| Genbank protein ID | AAG17704.1; EDL05587.1; EDL05585.1; BAA78420.1; AAH57926.1; |
| Genbank nucleotide ID | XM_017320017.1; NM_019724.4; |
| Ensembl protein ID | ENSMUSP00000029881 |
| Ensembl nucleotide ID | ENSMUSG00000028226 |
| Gene name | Matrix metalloproteinase-16 |
| Gene symbol | Mmp16 |
| Organism | Mus musculus |
| NCBI taxa ID | 10090 |
| Cleft type | CPO |
| Developmental stage | |
| Data sources | Manually collected |
| Reference | 18022611 |
| Functional description | Endopeptidase that degrades various components of the extracellular matrix, such as collagen type III and fibronectin. Activates progelatinase A. Involved in the matrix remodeling of blood vessels. It has no effect on type I, II, IV and V collagen. However, upon interaction with CSPG4, it may be involved in degradation and invasion of type I collagen by melanoma cells (By similarity). |
| Sequence | MILLAFSSGR RLDFVHRSGV FFLQTLLWIL CATVCGTEQY FNVEVWLQKY GYLPPTDPRM 60 SVLRSAETMQ SALAAMQQFY GINMTGKVDR NTIDWMKKPR CGVPDQTRGS SKFNIRRKRY 120 ALTGQKWQHK HITYSIKNVT PKVGDPETRR AIRRAFDVWQ NVTPLTFEEV PYSELENGKR 180 DVDITIIFAS GFHGDSSPFD GEGGFLAHAY FPGPGIGGDT HFDSDEPWTL GNPNHDGNDL 240 FLVAVHELGH ALGLEHSNDP TAIMAPFYQY METDNFKLPN DDLQGIQKIY GPPDKIPPPT 300 RPLPTVPPHR SVPPADPRRH DRPKPPRPPT GRPSYPGAKP NICDGNFNTL AILRREMFVF 360 KDQWFWRVRN NRVMDGYPMQ ITYFWRGLPP SIDAVYENSD GNFVFFKGNK YWVFKDTTLQ 420 PGYPHDLITL GNGIPPHGID SAIWWEDVGK TYFFKGDRYW RYSEEMKTMD PGYPKPITIW 480 KGIPESPQGA FVHKENGFTY FYKGKEYWKF NNQILKVEPG YPRSILKDFM GCDGPTDRDK 540 EGLSPPDDVD IVIKLDNTAS TVKAIAIVIP CILALCLLVL VYTVFQFKRK GTPRHILYCK 600 RSMQEWV 607 |
Abbreviation :
CLO : cleft lip only. CPO : cleft palate only.
CLP : cleft lip and palate. CL/P : cleft lip with/without cleft palate.
For humans: CL/P, CLO, CPO, and CLP. For mice: CLO, CLP, and CPO.
| Relation | Gene symbol | Entrez ID | UniProt ID | Cleft type | Developmental stage | Species | Evidence | Details |
|---|---|---|---|---|---|---|---|---|
| 1:1 ortholog | MMP16 | 282886 | F1N797 | Bos taurus | Prediction | More>> | ||
| 1:1 ortholog | MMP16 | 487036 | F1PLV8 | Canis lupus familiaris | Prediction | More>> | ||
| 1:1 ortholog | MMP16 | A0A452EG47 | Capra hircus | Prediction | More>> | |||
| 1:1 ortholog | MMP16 | 4325 | P51512 | Homo sapiens | Prediction | More>> | ||
| 1:1 ortholog | Mmp16 | 17389 | Q9WTR0 | CPO | Mus musculus | Publication | More>> | |
| 1:1 ortholog | MMP16 | A0A2I3SEA5 | Pan troglodytes | Prediction | More>> | |||
| 1:1 ortholog | MMP16 | 100153257 | A0A287AKC1 | Sus scrofa | Prediction | More>> | ||
| 1:1 ortholog | MMP16 | 100101605 | G1T0W4 | Oryctolagus cuniculus | Prediction | More>> | ||
| 1:1 ortholog | Mmp16 | F1M7F5 | Rattus norvegicus | Prediction | More>> |
| GO ID | GO Term | Evidence |
|---|---|---|
| GO:0004222 | metalloendopeptidase activity | ISO |
| GO:0004222 | metalloendopeptidase activity | IBA |
| GO:0008270 | zinc ion binding | ISO |
| GO:0070006 | metalloaminopeptidase activity | ISO |
| GO ID | GO Term | Evidence |
|---|---|---|
| GO:0001501 | skeletal system development | IBA |
| GO:0001503 | ossification | IGI |
| GO:0001958 | endochondral ossification | IGI |
| GO:0006508 | proteolysis | ISO |
| GO:0016485 | protein processing | ISO |
| GO:0030198 | extracellular matrix organization | IBA |
| GO:0030574 | collagen catabolic process | IDA |
| GO:0030574 | collagen catabolic process | IGI |
| GO:0030574 | collagen catabolic process | IBA |
| GO:0035988 | chondrocyte proliferation | IGI |
| GO:0048701 | embryonic cranial skeleton morphogenesis | IGI |
| GO:0060348 | bone development | IGI |
| GO:0097094 | craniofacial suture morphogenesis | IGI |
| GO ID | GO Term | Evidence |
|---|---|---|
| GO:0005615 | extracellular space | IBA |
| GO:0005887 | integral component of plasma membrane | ISO |
| GO:0005887 | integral component of plasma membrane | IBA |
| GO:0031012 | extracellular matrix | IEA |
| Reactome ID | Reactome Term | Evidence |
|---|---|---|
| R-MMU-1474228 | Degradation of the extracellular matrix | IEA |
| R-MMU-1474244 | Extracellular matrix organization | IEA |
| R-MMU-1592389 | Activation of Matrix Metalloproteinases | IEA |
| Keyword ID | Keyword Term |
|---|---|
| KW-0106 | Calcium |
| KW-1003 | Cell membrane |
| KW-0165 | Cleavage on pair of basic residues |
| KW-0177 | Collagen degradation |
| KW-1015 | Disulfide bond |
| KW-0325 | Glycoprotein |
| KW-0378 | Hydrolase |
| KW-0472 | Membrane |
| KW-0479 | Metal-binding |
| KW-0482 | Metalloprotease |
| KW-0645 | Protease |
| KW-1185 | Reference proteome |
| KW-0677 | Repeat |
| KW-0732 | Signal |
| KW-0812 | Transmembrane |
| KW-1133 | Transmembrane helix |
| KW-0862 | Zinc |
| KW-0865 | Zymogen |
| InterPro ID | InterPro Term |
|---|---|
| IPR000585 | Hemopexin-like_dom |
| IPR036375 | Hemopexin-like_dom_sf |
| IPR018487 | Hemopexin-like_repeat |
| IPR018486 | Hemopexin_CS |
| IPR033739 | M10A_MMP |
| IPR024079 | MetalloPept_cat_dom_sf |
| IPR028697 | MMP16 |
| IPR001818 | Pept_M10_metallopeptidase |
| IPR021190 | Pept_M10A |
| IPR021805 | Pept_M10A_metallopeptidase_C |
| IPR021158 | Pept_M10A_Zn_BS |
| IPR006026 | Peptidase_Metallo |
| IPR002477 | Peptidoglycan-bd-like |
| IPR036365 | PGBD-like_sf |