| Tag | Content |
|---|---|
| Uniprot ID | A0A2I3T3Q9 |
| Entrez ID | |
| Genbank protein ID | |
| Genbank nucleotide ID | |
| Ensembl protein ID | ENSPTRP00000083858 |
| Ensembl nucleotide ID | ENSPTRG00000005335 |
| Gene name | Apoptotic peptidase activating factor 1 |
| Gene symbol | APAF1 |
| Organism | Pan troglodytes |
| NCBI taxa ID | 9598 |
| Cleft type | |
| Developmental stage | |
| Data sources | Homology search |
| Reference | |
| Functional description | |
| Sequence | MDAKARNCLL QHREALEKDI KTSYIMDHMI SDGFLTISEE EKVRNEPTQQ QRAAMLIKMI 60 LKKDNDSYVS FYNALLHEGY KDLAALLHDG IPVVSSSSGK DSVSGITSYV RTVLCEGGVP 120 QRPVVFVTRK KLVNAIQQKL SKLKGEPGWV TIHGMAGCGK SVLAAEAVRD HSLLEGCFPG 180 GVHWVSVGKQ DKSGLLMKLQ NLCTRLDQDE SFSQRLPLNI EEAKDRLRIL MLRKHPRSLL 240 ILDDVWDSWV LKAFDNQCQI LLTTRDKSVT DSVMGPKYVV PVESSLGKEK GLEILSLFVN 300 MKKADLPEQA HSIIKECKGS PLVVSLIGAL LRDFPNRWEY YLKQLQNKQF KRIRKSSSYD 360 YEALDEAMSI SVEMLREDIK DYYTDLSILQ KDVKVPTKVL CILWDMETEE VEDILQEFVN 420 KSLLFCDRNG KSFRYYLHDL QVDFLTEKNC SQLQDLHKKI ITQFQRYHQP HTLSPDQEDC 480 MYWYNFLAYH MASAKMHKEL CALMFSLDWI KAKTELVGPA HLIHEFVEYR HILDEKDCAV 540 SENFQEFLSL NGHLLGRQPF PNIVQLGLCE PETSEVYQQA KLQAKQEVDN GMLYLEWINK 600 KNITNLSRLV VRPHTDAVYH ACFSEDGQRI ASCGADKTLQ VFKAETGEKL LEIKAHEDEV 660 LCCAFSTDDR FIATCSVDKK VKIWNSMTGE LVHTYDEHSE QVNCCHFTNS SHHLLLATGS 720 SDCFLKLWDL NQKECRNTMF GHTNSVNHCR FSPDDKLLAS CSADGTLKLW DATSANERKS 780 INVKQFFLNS EDPQEDMEVI VKCCSWSADG ARIIVAAKNK IFLWNIDSRS KVADCRGHLS 840 WVHGVMFSPD GSSFLTSSDD QTIRLWETKK VCKNSAVMLK QEVDVVFQEN EVMVLAVDHI 900 RRLQLINGRT GQIDYLTEAQ VSCCCLSPHL QYIAFGDENG AIEILELVNN RIFQSRFQHR 960 KTVWHIQFTA DEKTLISSSD DSEIQVWNWQ LDKCIFLRGH QETVKDFRLL KNSRLLSWSF 1020 DGTVKVWNII TGNKEKDFVC HQGTVLSCDI SHDATKFSST SADKTAKIWN VSNGELLHLC 1080 APLSEEGAAT HGGWVTDLCF SPDGKMLISA GGYIKWWNVV TGESSQTFYT NGTNLKKIHV 1140 SPDFKTYVTV DNLGILYILQ TLE 1163 |
Abbreviation :
CLO : cleft lip only. CPO : cleft palate only.
CLP : cleft lip and palate. CL/P : cleft lip with/without cleft palate.
For humans: CL/P, CLO, CPO, and CLP. For mice: CLO, CLP, and CPO.
| Relation | Gene symbol | Entrez ID | UniProt ID | Cleft type | Developmental stage | Species | Evidence | Details |
|---|---|---|---|---|---|---|---|---|
| 1:1 ortholog | APAF1 | A0A452G611 | Capra hircus | Prediction | More>> | |||
| 1:1 ortholog | APAF1 | 317 | O14727 | Homo sapiens | Prediction | More>> | ||
| 1:1 ortholog | Apaf1 | 11783 | O88879 | CPO | Mus musculus | Publication | More>> | |
| 1:1 ortholog | APAF1 | A0A2I3T3Q9 | Pan troglodytes | Prediction | More>> | |||
| 1:1 ortholog | Apaf1 | 78963 | Q9EPV5 | Rattus norvegicus | Prediction | More>> | ||
| 1:1 ortholog | apaf1 | 58131 | A5WVJ8 | Danio rerio | Prediction | More>> |
| GO ID | GO Term |
|---|---|
| GO:0043531 | ADP binding |
| GO:0042981 | regulation of apoptotic process |
| InterPro ID | InterPro Term |
|---|---|
| IPR041452 | APAF1_C |
| IPR037963 | APAF1_CARD_dom |
| IPR001315 | CARD |
| IPR011029 | DEATH-like_dom_sf |
| IPR020472 | G-protein_beta_WD-40_rep |
| IPR002182 | NB-ARC |
| IPR027417 | P-loop_NTPase |
| IPR011047 | Quinoprotein_ADH-like_supfam |
| IPR015943 | WD40/YVTN_repeat-like_dom_sf |
| IPR001680 | WD40_repeat |
| IPR019775 | WD40_repeat_CS |
| IPR017986 | WD40_repeat_dom |
| IPR036322 | WD40_repeat_dom_sf |
| IPR036388 | WH-like_DNA-bd_sf |