| Tag | Content |
|---|---|
| Uniprot ID | A0A452G611 |
| Entrez ID | |
| Genbank protein ID | |
| Genbank nucleotide ID | |
| Ensembl protein ID | ENSCHIP00000031977 |
| Ensembl nucleotide ID | ENSCHIG00000026050 |
| Gene name | Apoptotic protease-activating factor 1 |
| Gene symbol | APAF1 |
| Organism | Capra hircus |
| NCBI taxa ID | 9925 |
| Cleft type | |
| Developmental stage | |
| Data sources | Homology search |
| Reference | |
| Functional description | Oligomeric Apaf-1 mediates the cytochrome c-dependent autocatalytic activation of pro-caspase-9 (Apaf-3), leading to the activation of caspase-3 and apoptosis. This activation requires ATP. |
| Sequence | MDAKARNCLL QHREALERDI KTSYIMDHMI SNGVLTVSEE EKVKNEPTQR QRAAMLIKMI 60 LKKDNHSYIS FYNALLHEGY RDLAALLHGG IPVVSSSDGK DSVSGITSYV RTVLCEGGVP 120 QRPVVFVTRK KLVNAIQQKL SKLNGEPGWV TIYGMAGCGK SVLAAEAVRD HSFLEDCFPG 180 GVHWVSVGKQ DKSGLLMKLQ NLCARLDQDE SFSQRLPLNI EEAKDRLRIL MLRKHPRSLL 240 ILDDIWDPWV LKAFDNQCRI LLTTRDKSVT DSVMGPKYVV PVESGLGKEK ALEILSLFVN 300 MKKADLPEQA HSIIQECKGS PLVVSLIGAL LRDFPNRWEY YLRQLQNKQF KRIRKSSSYD 360 YEALDEAMSI SVEMLREDIK DYYTDLSIVQ KDVKVPTKVL CILWDLETEE VEDILQEFVN 420 KSLLFCDRNG KSFLYYLHDL QVDFLTEKNR SQLQDLHKKM VTQFQRHHQL YSLTPDQEDC 480 MYWYNFLAYH MASANMHKEL CALMFSLDWI KAKTELVGPA HLIHEFVEYR HILDEKDGTD 540 CENFQEFLSL NGHLLGRQPF PNIVQLGLCE LETSEVYRQA KLQAKQEVDN GMLYLEWVNK 600 KNMKNLSRLV VRPHTDAVYH ACFSEDGQRI ASCGADKTLQ VFKAETGEKL LEIKAHEDEV 660 LCCAFSADDR FIATCSVDKK VKIWNSMTGE LVRIYDEHSE QVNCCHFTNN SSHLLLATGS 720 NDYFLKLWDL NQEECRNTMF GHTNSVSHCR FSPDDQVLAS CSADGTLKLW DVKSANERKS 780 INVKQFFLNS EEPQEDLEVI VKCCSWSADG AKIMVAAKNK VFLFDIHTSG LLAEIHMGHH 840 STVQYCDFSP HNHLAVVALS QYCVELWSMD SGLKVADCRG HLSWVHCVMF SPDGSSFLTS 900 SDDQTVRLWE TKKVCKNSAT VLKQEIDVVF QEKEVTVLAV DNIRRLQILE LLNNRIFQSR 960 NAHKTTVRHI QFTADGKTLI SSSDDSAIQI WNWQSEDPFF LQAHQETVKD FKLLKNSRLL 1020 SWSFDGTVKV WNITTRRIEK DFVCHQDTVL SCDISSDGAK FSSTSADKTA KIWSFELLSP 1080 LHELRGHKGC VRCSSFSVDN TMLATGDDNG EIRMWNVSNG ELLHLCAPIS VEEGAATHGG 1140 WVTDLCFSPD NKMLVSAGGY LKWWNVVTGE SSQTFYTNGT NLKKIHVSPD FKTYVTVDNL 1200 GILYILKILE |
Abbreviation :
CLO : cleft lip only. CPO : cleft palate only.
CLP : cleft lip and palate. CL/P : cleft lip with/without cleft palate.
For humans: CL/P, CLO, CPO, and CLP. For mice: CLO, CLP, and CPO.
| Relation | Gene symbol | Entrez ID | UniProt ID | Cleft type | Developmental stage | Species | Evidence | Details |
|---|---|---|---|---|---|---|---|---|
| 1:1 ortholog | APAF1 | A0A452G611 | Capra hircus | Prediction | More>> | |||
| 1:1 ortholog | APAF1 | 317 | O14727 | Homo sapiens | Prediction | More>> | ||
| 1:1 ortholog | Apaf1 | 11783 | O88879 | CPO | Mus musculus | Publication | More>> | |
| 1:1 ortholog | APAF1 | A0A2I3T3Q9 | Pan troglodytes | Prediction | More>> | |||
| 1:1 ortholog | Apaf1 | 78963 | Q9EPV5 | Rattus norvegicus | Prediction | More>> | ||
| 1:1 ortholog | apaf1 | 58131 | A5WVJ8 | Danio rerio | Prediction | More>> |
| GO ID | GO Term |
|---|---|
| GO:0043293 | apoptosome |
| GO:0043531 | ADP binding |
| GO:0005524 | ATP binding |
| GO:0097190 | apoptotic signaling pathway |
| GO:0042981 | regulation of apoptotic process |
| InterPro ID | InterPro Term |
|---|---|
| IPR017251 | Apaf-1 |
| IPR041452 | APAF1_C |
| IPR037963 | APAF1_CARD_dom |
| IPR001315 | CARD |
| IPR011029 | DEATH-like_dom_sf |
| IPR020472 | G-protein_beta_WD-40_rep |
| IPR002182 | NB-ARC |
| IPR027417 | P-loop_NTPase |
| IPR015943 | WD40/YVTN_repeat-like_dom_sf |
| IPR001680 | WD40_repeat |
| IPR019775 | WD40_repeat_CS |
| IPR017986 | WD40_repeat_dom |
| IPR036322 | WD40_repeat_dom_sf |
| IPR036388 | WH-like_DNA-bd_sf |