Tag | Content |
---|---|
Uniprot ID | Q9EPV5 |
Entrez ID | 78963 |
Genbank protein ID | AAG35067.1 |
Genbank nucleotide ID | NM_023979.1 |
Ensembl protein ID | ENSRNOP00000010869 |
Ensembl nucleotide ID | ENSRNOG00000008022 |
Gene name | Apoptotic protease-activating factor 1 |
Gene symbol | Apaf1 |
Organism | Rattus norvegicus |
NCBI taxa ID | 10116 |
Cleft type | |
Developmental stage | |
Data sources | Homology search |
Reference | |
Functional description | Regulates programmed cell death; necessary for normal brain development. Participates with pro-caspase-9 (Apaf-3) in the cytochrome c-dependent activation of caspase-3, leading to apoptosis. This activation requires ATP (By similarity). |
Sequence | MDAKARNCLL QHKEALEKDI KTSYIMDHMI SNGVLTVVEE EKVKSQATQY QRAAALIKMI 60 LNKDNYAYIS FYNALLHEGY KDLAGLLHSG LPLVSSSSGK DTDGGNTSFV RTVLCEGGVP 120 QRPVIFVTRK KLVSAIQQKL WKLNGEPGWV TIYGMAGCGK SVLAAEAVRD HALLEGCFSG 180 GVHWVSIGKQ DKSGLLMKLQ NLCTRLGQEE SFSQRLPLNI EEAKDRLRVL MLRKHPRSLL 240 ILDDVWDPWV LKAFDNQCQI LLTTRDKSVT DSVMGPKYVI PVESGLGKEK GLEILSLFVN 300 MKKEDLPVEA HSIIKECKGS PLVVSLVGAL LRDFPNRWAY YLRQLQNKQF KRIRKSSSYD 360 YEALDEAMSI SVEMLREDIK DYYTDLSILQ KDVKVPTKVL CVLWDLETEE VEDILQEFVN 420 KSLLFCNRNG KSFCYYLHDL QVDFLTEKNR SQLQDLHRKM VTQFQRYHQP HTLSPGQEDC 480 MYWYNFLAYH MASAGMHKEL CALMFSLDWI KAKTELVGPA HLIHEFVEYR HILDEKDCAV 540 CENFQEFLSL NGHLLGRQPF PNIVQLGLCE PETSEVYQQA KLQAKQEVDT GRLYLEWINK 600 KTIKNLSRLV VRPHTDAVYH ACFSQDGQRI ASCGADKTLQ VFKAETGEKL LDIKAHEDEV 660 LCCAFSSDDS YIATCSVDKK VKIWDSGTGK LVHTYEEHSE QVNCCHFTNK SNHLLLATGS 720 NDSFLKLWDL NQKECRNTMF GHTNSVTHCR FSPDDELLAS CSADGTLKLW DVRSANEKKS 780 INVKRFFLSS EDPPEDVEVI VKCCSWSADG DRIIVAAKNK VLLLDIHTSG LLTEIHTGHH 840 STIQYCDFSP YDHLAVIALS QYCVELWNID SRVKVADCRG HLSWVHGVMF SPDGSSFLTA 900 SDDQTIRVWE TRKVCKNSAI VLKQEIDVVF QENEMMVLAV DNIRGLQLIA GKTGQIDYLP 960 EAQVSCCCLS PHLEYVAFGD EEGAIKIIEL PNNRVFSSGI GHKKAVRHIQ FTADGKTLIS 1020 SSEDSVIQVW NWQTEEYVFL QAHQETVKDF RLLRDSRLLS WSFDGTVKVW NVITGRIERD 1080 FTCHQGTVLS CAISSDATKF SSTSADKTAK IWSFELPSPL HELKGHNSCV RCSAFSLDGI 1140 LLATGDDNGE IRIWNVSDGQ LLHLCAPISI EEGTATHGGW VTDVCFSPDR KMLVSAGGYL 1200 KWWNVVTGES SQTFYTNGTN LKKIHVSPDF RTYVTVDNLG ILYILQVLE 1249 |
Abbreviation :
CLO : cleft lip only. CPO : cleft palate only.
CLP : cleft lip and palate. CL/P : cleft lip with/without cleft palate.
For humans: CL/P, CLO, CPO, and CLP. For mice: CLO, CLP, and CPO.
Relation | Gene symbol | Entrez ID | UniProt ID | Cleft type | Developmental stage | Species | Evidence | Details |
---|---|---|---|---|---|---|---|---|
1:1 ortholog | APAF1 | A0A452G611 | Capra hircus | Prediction | More>> | |||
1:1 ortholog | APAF1 | 317 | O14727 | Homo sapiens | Prediction | More>> | ||
1:1 ortholog | Apaf1 | 11783 | O88879 | CPO | Mus musculus | Publication | More>> | |
1:1 ortholog | APAF1 | A0A2I3T3Q9 | Pan troglodytes | Prediction | More>> | |||
1:1 ortholog | Apaf1 | 78963 | Q9EPV5 | Rattus norvegicus | Prediction | More>> | ||
1:1 ortholog | apaf1 | 58131 | A5WVJ8 | Danio rerio | Prediction | More>> |
GO ID | GO Term |
---|---|
GO:0043293 | apoptosome |
GO:0005737 | cytoplasm |
GO:0005829 | cytosol |
GO:0005634 | nucleus |
GO:0032991 | protein-containing complex |
GO:0043531 | ADP binding |
GO:0005524 | ATP binding |
GO:0008656 | cysteine-type endopeptidase activator activity involved in apoptotic process |
GO:0031072 | heat shock protein binding |
GO:0042802 | identical protein binding |
GO:0006919 | activation of cysteine-type endopeptidase activity involved in apoptotic process |
GO:0008635 | activation of cysteine-type endopeptidase activity involved in apoptotic process by cytochrome c |
GO:0007568 | aging |
GO:0007420 | brain development |
GO:0010659 | cardiac muscle cell apoptotic process |
GO:0030154 | cell differentiation |
GO:0071560 | cellular response to transforming growth factor beta stimulus |
GO:0030900 | forebrain development |
GO:0070059 | intrinsic apoptotic signaling pathway in response to endoplasmic reticulum stress |
GO:0001822 | kidney development |
GO:0007275 | multicellular organism development |
GO:0001843 | neural tube closure |
GO:0051402 | neuron apoptotic process |
GO:2001235 | positive regulation of apoptotic signaling pathway |
GO:1902510 | regulation of apoptotic DNA fragmentation |
GO:0001666 | response to hypoxia |
GO:0007584 | response to nutrient |
InterPro ID | InterPro Term |
---|---|
IPR017251 | Apaf-1 |
IPR041452 | APAF1_C |
IPR037963 | APAF1_CARD_dom |
IPR001315 | CARD |
IPR011029 | DEATH-like_dom_sf |
IPR020472 | G-protein_beta_WD-40_rep |
IPR002182 | NB-ARC |
IPR027417 | P-loop_NTPase |
IPR015943 | WD40/YVTN_repeat-like_dom_sf |
IPR001680 | WD40_repeat |
IPR019775 | WD40_repeat_CS |
IPR017986 | WD40_repeat_dom |
IPR036322 | WD40_repeat_dom_sf |
IPR036388 | WH-like_DNA-bd_sf |