| Tag | Content |
|---|---|
| Uniprot ID | A5WVJ8; E7F2V1; |
| Entrez ID | 58131 |
| Genbank protein ID | |
| Genbank nucleotide ID | XM_005164770.3; XM_005164769.2; |
| Ensembl protein ID | ENSDARP00000008347 |
| Ensembl nucleotide ID | ENSDARG00000021239 |
| Gene name | Apoptotic protease-activating factor 1 |
| Gene symbol | apaf1 |
| Organism | Danio rerio |
| NCBI taxa ID | 7955 |
| Cleft type | |
| Developmental stage | |
| Data sources | Homology search |
| Reference | |
| Functional description | Oligomeric Apaf-1 mediates the cytochrome c-dependent autocatalytic activation of pro-caspase-9 (Apaf-3), leading to the activation of caspase-3 and apoptosis. This activation requires ATP. |
| Sequence | MEERARSRLL RSKATLEQDI KASYLMDHMI SDGVLTNDEE AKVLSKATRK EQAVALLETL 60 LRKDNRAYIS FYNALIRESY GDLASLLHSD LPLLSPEGEK SFADGVSPSV QAILSVGGVP 120 QRPVVFVSRP PLLNLIREML YRLRDTPGWV TVFGMAGSGK SVMAAEVVRD RSLIKECFPD 180 GVHWLSVGQC ERADLLVRMQ SLCFRLEQCQ SSDTSQRPPS TVEEAKERLR FLMLRRFPRS 240 LLILDDVWDS SSLRSFDIQC RVLLTTRNRA LTDSVSGVRY EVPVENGLDE EKALEILALY 300 VNGKMHKLPE QARSIVSECK GSPLVVSLIG ALLREFPDRW SYYLRQLQQK QFKRIRKSSS 360 YDYEALDQAM DASLQVLEAE HQELYRDLSV MQKDIKVPAK VLSVLWGLEL EEVEDVLQEF 420 VNKSLLFRDC NQRPYRYYLH DLQLDFLAEQ NRDQIAELHK KMVRQYQRFY SKRPPDSADK 480 DSLYWYQFIP YHMAKAGLSK ELYSLMFSLD WVKEKARIMG SAHLINDYVE YGEILDKENS 540 EVRVQFQEFL SLNGHHLEQR PFPDVVQLAL SQPDRSEVYR QALMQAQKRA SRGQIYLNWV 600 NKNIEEGLSR LVMHPHQGAV YYACFSKDGS KIASCGASKA LRVFKSTSGE KLLELQAHEE 660 DVLCCAFSPD DRHIATCASD KKVKLWNVER GVLIREFEVE HEEQINHCQF TNTGRRVLLA 720 TCSNDKFTNT KLWNPNKKTS QNTMFGHMEP VNHCCFSPND LYLATSSSDG SLKLFEVSSA 780 NEWKSIDVDS FFPESDEEIK AMVKCSTWSA DGSQIICAAR NTVFVFDVET SDLLLELKTS 840 RLSTIQFCHA CPNSSLLAVA LSHYTVELWN FESSKKKAEC SGHLSWVHCV QFSPDGSLLL 900 SSSDDQTIRL WETDRVHTSS AVALKRDTDV LFSHSDATII APDSSNRLQV LSGSTGAVVL 960 ESEELSSRIR CSCISRNAAF VALGSEDGTV QVIEVPSSKA SVKLSGHTKT VHHCQFTDDC 1020 EILITSSEDS TIRVWKWRTG ECMVLQGHME PVRKFHLLSS SSSPRLFSWS FDGTVKVWDL 1080 TRGQMLQDLV CHEGAVLSCD VSSDGRLFAT TSANRTAKVW SSASWKMIFL LEGHKDCVRS 1140 CRFSWDNKRL ATGDDNGEIR LWSMLDGALL KICSRDTKDS MDSYHGGWVT DLHFSPDNRV 1200 LVSTGGYIKW WSVESGEALQ TFYTMGGNLK KIHVSPDFST FITVDSIGIL YILKRLEGEG 1260 T 1261 |
Abbreviation :
CLO : cleft lip only. CPO : cleft palate only.
CLP : cleft lip and palate. CL/P : cleft lip with/without cleft palate.
For humans: CL/P, CLO, CPO, and CLP. For mice: CLO, CLP, and CPO.
| Relation | Gene symbol | Entrez ID | UniProt ID | Cleft type | Developmental stage | Species | Evidence | Details |
|---|---|---|---|---|---|---|---|---|
| 1:1 ortholog | APAF1 | A0A452G611 | Capra hircus | Prediction | More>> | |||
| 1:1 ortholog | APAF1 | 317 | O14727 | Homo sapiens | Prediction | More>> | ||
| 1:1 ortholog | Apaf1 | 11783 | O88879 | CPO | Mus musculus | Publication | More>> | |
| 1:1 ortholog | APAF1 | A0A2I3T3Q9 | Pan troglodytes | Prediction | More>> | |||
| 1:1 ortholog | Apaf1 | 78963 | Q9EPV5 | Rattus norvegicus | Prediction | More>> | ||
| 1:1 ortholog | apaf1 | 58131 | A5WVJ8 | Danio rerio | Prediction | More>> |
| GO ID | GO Term |
|---|---|
| GO:0043293 | apoptosome |
| GO:0043531 | ADP binding |
| GO:0005524 | ATP binding |
| GO:0097190 | apoptotic signaling pathway |
| GO:0042981 | regulation of apoptotic process |
| InterPro ID | InterPro Term |
|---|---|
| IPR017251 | Apaf-1 |
| IPR041452 | APAF1_C |
| IPR037963 | APAF1_CARD_dom |
| IPR001315 | CARD |
| IPR011029 | DEATH-like_dom_sf |
| IPR020472 | G-protein_beta_WD-40_rep |
| IPR002182 | NB-ARC |
| IPR027417 | P-loop_NTPase |
| IPR015943 | WD40/YVTN_repeat-like_dom_sf |
| IPR001680 | WD40_repeat |
| IPR019775 | WD40_repeat_CS |
| IPR017986 | WD40_repeat_dom |
| IPR036322 | WD40_repeat_dom_sf |
| IPR036388 | WH-like_DNA-bd_sf |