| Tag | Content |
|---|---|
| Uniprot ID | A0A2I3T5C9; A0A2J8LKT8; |
| Entrez ID | 459171 |
| Genbank protein ID | |
| Genbank nucleotide ID | XM_009442353.2 |
| Ensembl protein ID | ENSPTRP00000084061 |
| Ensembl nucleotide ID | ENSPTRG00000011857 |
| Gene name | SOS Ras/Rac guanine nucleotide exchange factor 1 |
| Gene symbol | SOS1 |
| Organism | Pan troglodytes |
| NCBI taxa ID | 9598 |
| Cleft type | |
| Developmental stage | |
| Data sources | Homology search |
| Reference | |
| Functional description | |
| Sequence | MQAQQLPYEF FSEENAPKWR GLLVPALKKV QGQVHPTLES NDDALQYVEE LILQLLNMLC 60 QAQPRSASDV EERVQKSFPH PIDKWAIADA QSAIEKRKRR NPLSLPVEKI HPLLKEVLGY 120 KIDHQVSVYI VAVLEYISAD ILKLVGNYVR NIRHYEITKQ DIKVAMCADK VLMDMFHQDV 180 EDINILSLTD EEPSTSGEQT YYDLVKAFMA EIRQYIRELN LIIKVFREPF VSNSKLFSAN 240 DVENIFSRIV DIHELSVKLL GHIEDTVEMT DEGSPHPLVG SCFEDLAEEL AFDPYESYAR 300 DILRPGFHDR FLSQLSKPGA ALYLQSIGEG FKEAVQYVLP RLLLAPVYHC LHYFELLKQL 360 EEKSEDQEDK ECLKQAITAL LNVQSGMEKI CSKSLAKRRL SESACRFYSQ QMKGKQLAIK 420 KMNEIQKNID GWEGKDIGQC CNEFIMEGTL TRVGAKHERH IFLFDGLMIC CKSNHGQPRL 480 PGASNAEYRL KEKFFMRKVQ INDKDDTNEY KHAFEIILKD ENSVIFSAKS AEEKNNWMAA 540 LISLQYRSTL ERMLDVTMLQ EEKEEQMRLP SADVYRFAEP DSEENIIFEE NMQPKAGIPI 600 IKAGTVIKLI ERLTYHMYAD PNFVRTFLTT YRSFCKPQEL LSLIIERFEI PEPEPTEADR 660 IAIENGDQPL SAELKRFRKE YIQPVQLRVL NVCRHWVEHH FYDFERDAYL LQRMEEFIGT 720 VRGKAMKKWV ESITKIIQRK KIARDNGPGH NITFQSSPPT VEWHISRPGH IETFDLLTLH 780 PIEIARQLTL LESDLYRAVQ PSELVGSVWT KEDKEINSPN LLKMIRHTTN LTLWFEKCIV 840 ETENLEERVA VVSRIIEILQ VFQELNNFNG VLEVVSAMNS SPVYRLDHTF EQIPSRQKKI 900 LEEAHELSED HYKKYLAKLR SINPPCVPFF GIYLTNILKT EEGNPEVLKR HGKELINFSK 960 RRKVAEITGE IQQYQNQPYC LRVESDIKRF FENLNPMGNS MEKEFTDYLF NKSLEIEPRN 1020 PKPLPRFPKK YSYPLKSPGV RPSNPRPGTM RHPTPLQQEP RKISYSRIPE SETESTASAP 1080 NSPRTPLTPP PASGASSTTD VCSVFDSDHS SPFHSRSASV SSISLTKGTD EVPVPPPVPP 1140 RRRPESAPAE SSPSKIMSKH LDSPPAIPPR QPTSKAYSPR YSLSDRTSIS DPPESPPLLP 1200 PREPVRTPDV FSSSPLHLQP PPLGKKSDHG NTFFPNSPSP FTPPPPQTPS PHGTRRHLPS 1260 PPLTQEVDLH SIAGPPVPPR QSTSQHIPKL PPKTYKREHT HPSMHRDGPP LLENAHSS 1318 |
Abbreviation :
CLO : cleft lip only. CPO : cleft palate only.
CLP : cleft lip and palate. CL/P : cleft lip with/without cleft palate.
For humans: CL/P, CLO, CPO, and CLP. For mice: CLO, CLP, and CPO.
| Relation | Gene symbol | Entrez ID | UniProt ID | Cleft type | Developmental stage | Species | Evidence | Details |
|---|---|---|---|---|---|---|---|---|
| 1:1 ortholog | SOS1 | 102185660 | A0A452F6Z1 | Capra hircus | Prediction | More>> | ||
| 1:1 ortholog | SOS1 | 100053889 | F6RQQ4 | Equus caballus | Prediction | More>> | ||
| 1:1 ortholog | SOS1 | 6654 | Q07889 | Homo sapiens | Prediction | More>> | ||
| 1:1 ortholog | Sos1 | 20662 | Q62245 | CPO | Mus musculus | Publication | More>> | |
| 1:1 ortholog | SOS1 | 459171 | A0A2I3T5C9 | Pan troglodytes | Prediction | More>> | ||
| 1:1 ortholog | Sos1 | 313845 | D4A3T0 | Rattus norvegicus | Prediction | More>> |
| GO ID | GO Term |
|---|---|
| GO:0000786 | nucleosome |
| GO:0003677 | DNA binding |
| GO:0005085 | guanyl-nucleotide exchange factor activity |
| GO:0046982 | protein heterodimerization activity |
| GO:0007264 | small GTPase mediated signal transduction |
| Keyword ID | Keyword Term |
|---|---|
| KW-1185 | Reference proteome |
| InterPro ID | InterPro Term |
|---|---|
| IPR035899 | DBL_dom_sf |
| IPR000219 | DH-domain |
| IPR009072 | Histone-fold |
| IPR007125 | Histone_H2A/H2B/H3 |
| IPR011993 | PH-like_dom_sf |
| IPR001849 | PH_domain |
| IPR008937 | Ras-like_GEF |
| IPR000651 | Ras-like_Gua-exchang_fac_N |
| IPR019804 | Ras_G-nucl-exch_fac_CS |
| IPR023578 | Ras_GEF_dom_sf |
| IPR001895 | RASGEF_cat_dom |
| IPR036964 | RASGEF_cat_dom_sf |