Gene: SOS1

Basic information

Tag Content
Uniprot ID F6RQQ4
Entrez ID 100053889
Genbank protein ID
Genbank nucleotide ID XM_005600032.2
Ensembl protein ID ENSECAP00000015689
Ensembl nucleotide ID ENSECAG00000017604
Gene name SOS Ras/Rac guanine nucleotide exchange factor 1
Gene symbol SOS1
Organism Equus caballus
NCBI taxa ID 9796
Cleft type
Developmental stage
Data sources Homology search
Reference
Functional description
Sequence
MQAQQLPYEF FSEENAPKWR GLLVPALKKV QGQVHPTLES SDDALQYVEE LILQLLNMLC 60
QAQPRSASDV EERVQKSFPH PIDKWAIADA QSAIEKRKRR NPLSLPVEKI HPLLKEVLGY 120
KIDHQVSVYI VAVLEYISAD ILKLVGNYVR NIRHYEITKQ DIKVAMCADK VLMDMFHQDV 180
EDINILSLTD EEPSTSGEQT YYDLVKAFMA EIRQYIRELN LIIKVFREPF VSNSKLFSAN 240
DVENIFSRIV DIHELSVKLL GHIEDTVEMT DEGSPHPLVG SCFEDLAEEL AFDPYESYAR 300
DILRPGFHDH FLSQLSKPGA ALYLQSIGEG FKEAVQYVLP RLLLAPVYHC LHYFELLKQL 360
EEKSEDQEDK ECLKQAITAL LNVQSGMEKI CSKSLAKRRL SESACRFYSQ QMKGKQLAIK 420
KMNEIQKNID GWEGKDIGQC CNEFIMEGTL TRVGAKHERH IFLFDGLMIC CKSNHGQPRL 480
PGASNAEYRL KEKFFMRKVQ INDKDDTSEY KHAFEIILKD ENSVIFSAKS AEEKNNWMAA 540
LISLQYRSTL ERMLDVTMLQ EEKEEQMRLP SADVYRFAEP DSEENIIFEE NMQPKAGIPI 600
IKAGTVIKLI ERLTYHMYAD PNFVRTFLTT YRSFCKPQEL LSLIIERFEI PEPEPTEADR 660
IAIENGDQPL SAELKRFRKE YIQPVQLRVL NVCRHWVEHH FYDFERDADL LQRMEEFIGT 720
VRGKAMKKWV ESITKIIQRK KIARDNGPGH NITFQSSPPT VEWHISRPGH IETFDLLTLH 780
PIEIARQLTL LESDLYRAVQ PSELVGSVWT KEDKEINSPN LLKMIRHTTN LTLWFEKCIV 840
ETENLEERVA VVNRIIEILQ VFQELNNFNG VLEVVSAMNS SPVYRLDHTF EQIPSRQKKI 900
LEEAHELSED HYKKYLAKLR SINPPCVPFF GIYLTNILKT EEGNPEVLKR HGKDLINFSK 960
RRKVAEITGE IQQYQNQPYC LRVESDIKRF FENLNPMGNS MEKEFTDYLF NKSLEIEPRN 1020
PKPLPRFPKK YSYPLKSPGV RPSNPRPGTM RHPTPLQQEP RKISYSRIPE SETESTASAP 1080
NSPRTPLTPP PASGASSTTD VCSVFDSDHS SPFHSSSDTV FIQVTLPHGP RSASVSSISL 1140
TKGTDEVPVP PPVPPRRRPE SAPAESSPSK IMSKHLDSPP AIPPRQPTSK AYSPRYSISE 1200
RTSISDPPES PPLLPPREPV RTPDVFSSSP LHLQPPPLGK KSDHGNAFFP NSPSPFTPPP 1260
PQTPSPHGTR RHLPSPPLTQ EVDLHSIAGP PVPPRQSTSQ HIPKLPPKTY KREHTHPSMH 1320
RDGPPLLENA HSS 1333

Abbreviation :
CLO : cleft lip only. CPO : cleft palate only. CLP : cleft lip and palate. CL/P : cleft lip with/without cleft palate.
For humans: CL/P, CLO, CPO, and CLP. For mice: CLO, CLP, and CPO.

Protein disorder information

Orthologous information

Relation Gene symbol Entrez ID UniProt ID Cleft type Developmental stage Species Evidence Details
1:1 orthologSOS1102185660A0A452F6Z1Capra hircusPredictionMore>>
1:1 orthologSOS1100053889F6RQQ4Equus caballusPredictionMore>>
1:1 orthologSOS16654Q07889Homo sapiensPredictionMore>>
1:1 orthologSos120662Q62245CPOMus musculusPublicationMore>>
1:1 orthologSOS1459171A0A2I3T5C9Pan troglodytesPredictionMore>>
1:1 orthologSos1313845D4A3T0Rattus norvegicusPredictionMore>>

Gene ontology

GO ID GO Term
GO:0000786 nucleosome
GO:0003677 DNA binding
GO:0005085 guanyl-nucleotide exchange factor activity
GO:0046982 protein heterodimerization activity
GO:0007264 small GTPase mediated signal transduction

Functional annotations

Keywords

Keyword ID Keyword Term
KW-0344 Guanine-nucleotide releasing factor
KW-1185 Reference proteome

Interpro

InterPro ID InterPro Term
IPR035899 DBL_dom_sf
IPR000219 DH-domain
IPR009072 Histone-fold
IPR007125 Histone_H2A/H2B/H3
IPR011993 PH-like_dom_sf
IPR001849 PH_domain
IPR008937 Ras-like_GEF
IPR000651 Ras-like_Gua-exchang_fac_N
IPR019804 Ras_G-nucl-exch_fac_CS
IPR023578 Ras_GEF_dom_sf
IPR001895 RASGEF_cat_dom
IPR036964 RASGEF_cat_dom_sf

PROSITE

PROSITE ID PROSITE Term
PS50010 DH_2
PS50003 PH_DOMAIN
PS00720 RASGEF
PS50009 RASGEF_CAT
PS50212 RASGEF_NTER

Pfam

Pfam ID Pfam Term
PF00125 Histone
PF00169 PH
PF00617 RasGEF
PF00618 RasGEF_N
PF00621 RhoGEF