| Tag | Content |
|---|---|
| Uniprot ID | Q62245; Q62244; |
| Entrez ID | 20662 |
| Genbank protein ID | CAA77662.1; CAA77665.1; |
| Genbank nucleotide ID | NM_009231.2 |
| Ensembl protein ID | ENSMUSP00000067786 |
| Ensembl nucleotide ID | ENSMUSG00000024241 |
| Gene name | Son of sevenless homolog 1 |
| Gene symbol | Sos1 |
| Organism | Mus musculus |
| NCBI taxa ID | 10090 |
| Cleft type | CPO |
| Developmental stage | |
| Data sources | Manually collected |
| Reference | 9030684; 21041952; |
| Functional description | Promotes the exchange of Ras-bound GDP by GTP. Probably by promoting Ras activation, regulates phosphorylation of MAP kinase MAPK3 in response to EGF (By similarity). Catalytic component of a trimeric complex that participates in transduction of signals from Ras to Rac by promoting the Rac-specific guanine nucleotide exchange factor (GEF) activity (PubMed:10499589, PubMed:11524436). |
| Sequence | MQAQQLPYEF FSEENAPKWR GLLVPALKKV QGQVHPTLES NDDALQYVEE LILQLLNMLC 60 QAQPRSASDV EERVQKSFPH PIDKWAIADA QSAIEKRKRR NPLSLPAERI HHLLREVLGY 120 KIDHQVSVYI VAVLEYISAD ILKLVGNYVR NIRHYEITKQ DIKVAMCADK VLMDMFHQDV 180 EDINILSLTD EEPSTSGEQT YYDLVKAFMA EIRQYIRELN LIIKVFREPF VSNSKLFSSN 240 DVENIFSRIV DIHELSVKLL GHIEDTVEMT DEGSPHPLVG SCFEDLAEEL AFDPYESYAR 300 DILRPGFHGH FLSQLSKPGA ALYLQSIGEG FKEAVQYVLP RLLLAPVYHC LHYFELLKQL 360 EEKSEDQEDK ECMKQAITAL LNVQSGMEKI CSKSLAKRRL SESACRFYSQ QMKGKQLAIK 420 KMNEIQKNID GWEGKDIGQC CNEFIMEGTL TRVGAKHERH IFLFDGLMIC CKSNHGQPRL 480 PGASSAEYRL KEKFFMRKVQ INDKDDTSEY KHAFEIILKD GNSVIFSAKS AEEKNNWMAA 540 LISLQYRSTL ERMLDVTVLQ EEKEEQMRLP SAEVYRFAEP DSEENILFEE NVQPKAGIPI 600 IKAGTVLKLI ERLTYHMYAD PNFVRTFLTT YRSFCRPQEL LSLLIERFEI PEPEPTEADR 660 IAIENGDQPL SAELKRFRKE YIQPVQLRVL NVCRHWVEHH FYDFERDADL LQRMEEFIGT 720 VRGKAMKKWV ESITKIIQRK KIARDNGPGH NITFQSSPPT VEWHISRPGH IETFDLLTLH 780 PIEIARQLTL LESDLYRAVQ PSELVGSVWT KEDKEINSPN LLKMIRHTTN LTLWFEKCIV 840 ETENLEERVA VVSRIIEILQ VFQELNNFNG VLEVVSAMNS SPVYRLDHTF EQIPSRQKKI 900 LEEAHELSED HYKKYLAKLR SINPPCVPFF GIYLTNILKT EEGNPEVLRR HGKELINFSK 960 RRRVAEITGE IQQYQNQPYC LRVEPDIKRF FENLNPMGNS MEKEFTDYLF NKSLEIEPRH 1020 PKPLPRFPKK YSYPLKSPGV RPSNPRPGTM RHPTPLQQEP RKISYSRIPE SETESTASAP 1080 NSPRTPLTPP PASGTSSNTD VCSVFDSDHS ASPFHSRSAS VSSISLSKGT DEVPVPPPVP 1140 PRRRPESAPA ESSPSKIMSK HLDSPPAIPP RQPTSKAYSP RYSISDRTSI SDPPESPPLL 1200 PPREPVRTPD VFSSSPLHLQ PPPLGKKSDH GNAFFPNSPS PFTPPPPQTP SPHGTRRHLP 1260 SPPLTQEMDL HSIAGPPVPP RQSTSQLIPK LPPKTYKREH THPSMHRDGP PLLENAHSS 1319 |
Abbreviation :
CLO : cleft lip only. CPO : cleft palate only.
CLP : cleft lip and palate. CL/P : cleft lip with/without cleft palate.
For humans: CL/P, CLO, CPO, and CLP. For mice: CLO, CLP, and CPO.
| Relation | Gene symbol | Entrez ID | UniProt ID | Cleft type | Developmental stage | Species | Evidence | Details |
|---|---|---|---|---|---|---|---|---|
| 1:1 ortholog | SOS1 | 102185660 | A0A452F6Z1 | Capra hircus | Prediction | More>> | ||
| 1:1 ortholog | SOS1 | 100053889 | F6RQQ4 | Equus caballus | Prediction | More>> | ||
| 1:1 ortholog | SOS1 | 6654 | Q07889 | Homo sapiens | Prediction | More>> | ||
| 1:1 ortholog | Sos1 | 20662 | Q62245 | CPO | Mus musculus | Publication | More>> | |
| 1:1 ortholog | SOS1 | 459171 | A0A2I3T5C9 | Pan troglodytes | Prediction | More>> | ||
| 1:1 ortholog | Sos1 | 313845 | D4A3T0 | Rattus norvegicus | Prediction | More>> |
| GO ID | GO Term | Evidence |
|---|---|---|
| GO:0003677 | DNA binding | IEA |
| GO:0005085 | guanyl-nucleotide exchange factor activity | ISO |
| GO:0005088 | Ras guanyl-nucleotide exchange factor activity | ISO |
| GO:0005088 | Ras guanyl-nucleotide exchange factor activity | EXP |
| GO:0005088 | Ras guanyl-nucleotide exchange factor activity | IMP |
| GO:0005515 | protein binding | IPI |
| GO:0017124 | SH3 domain binding | ISO |
| GO:0046982 | protein heterodimerization activity | IEA |
| GO ID | GO Term | Evidence |
|---|---|---|
| GO:0001782 | B cell homeostasis | IGI |
| GO:0001942 | hair follicle development | IGI |
| GO:0002260 | lymphocyte homeostasis | IGI |
| GO:0003007 | heart morphogenesis | IMP |
| GO:0003209 | cardiac atrium morphogenesis | IMP |
| GO:0003344 | pericardium morphogenesis | IMP |
| GO:0007173 | epidermal growth factor receptor signaling pathway | IMP |
| GO:0007264 | small GTPase mediated signal transduction | IMP |
| GO:0007265 | Ras protein signal transduction | ISO |
| GO:0007296 | vitellogenesis | IMP |
| GO:0033081 | regulation of T cell differentiation in thymus | IGI |
| GO:0035264 | multicellular organism growth | IMP |
| GO:0042129 | regulation of T cell proliferation | IGI |
| GO:0045742 | positive regulation of epidermal growth factor receptor signaling pathway | IEA |
| GO:0046579 | positive regulation of Ras protein signal transduction | TAS |
| GO:0048011 | neurotrophin TRK receptor signaling pathway | ISO |
| GO:0048514 | blood vessel morphogenesis | IMP |
| GO:0051057 | positive regulation of small GTPase mediated signal transduction | ISO |
| GO:0060021 | roof of mouth development | IMP |
| GO:0061029 | eyelid development in camera-type eye | IGI |
| GO:0061384 | heart trabecula morphogenesis | IMP |
| GO:1904693 | midbrain morphogenesis | IMP |
| GO:2000973 | regulation of pro-B cell differentiation | IGI |
| GO ID | GO Term | Evidence |
|---|---|---|
| GO:0000786 | nucleosome | IEA |
| GO:0005737 | cytoplasm | ISO |
| GO:0005829 | cytosol | TAS |
| GO:0005886 | plasma membrane | ISO |
| GO:0014069 | postsynaptic density | ISO |
| GO:0043025 | neuronal cell body | ISO |
| Reactome ID | Reactome Term | Evidence |
|---|---|---|
| R-MMU-109582 | Hemostasis | IEA |
| R-MMU-112399 | IRS-mediated signalling | IEA |
| R-MMU-112412 | SOS-mediated signalling | IEA |
| R-MMU-1227986 | Signaling by ERBB2 | IEA |
| R-MMU-1236394 | Signaling by ERBB4 | IEA |
| R-MMU-1250347 | SHC1 events in ERBB4 signaling | IEA |
| R-MMU-1266738 | Developmental Biology | IEA |
| R-MMU-1280215 | Cytokine Signaling in Immune system | IEA |
| R-MMU-1280218 | Adaptive Immune System | IEA |
| R-MMU-1433557 | Signaling by SCF-KIT | IEA |
| R-MMU-1433559 | Regulation of KIT signaling | IEA |
| R-MMU-162582 | Signal Transduction | IEA |
| R-MMU-166520 | Signaling by NTRKs | IEA |
| R-MMU-167044 | Signalling to RAS | IEA |
| R-MMU-168249 | Innate Immune System | IEA |
| R-MMU-168256 | Immune System | IEA |
| R-MMU-177929 | Signaling by EGFR | IEA |
| R-MMU-179812 | GRB2 events in EGFR signaling | IEA |
| R-MMU-180336 | SHC1 events in EGFR signaling | IEA |
| R-MMU-186763 | Downstream signal transduction | IEA |
| R-MMU-186797 | Signaling by PDGF | IEA |
| R-MMU-187037 | Signaling by NTRK1 (TRKA) | IEA |
| R-MMU-187687 | Signalling to ERKs | IEA |
| R-MMU-190236 | Signaling by FGFR | IEA |
| R-MMU-193648 | NRAGE signals death through JNK | IEA |
| R-MMU-193704 | p75 NTR receptor-mediated signalling | IEA |
| R-MMU-194315 | Signaling by Rho GTPases | IEA |
| R-MMU-194840 | Rho GTPase cycle | IEA |
| R-MMU-1963640 | GRB2 events in ERBB2 signaling | IEA |
| R-MMU-202733 | Cell surface interactions at the vascular wall | IEA |
| R-MMU-204998 | Cell death signalling via NRAGE, NRIF and NADE | IEA |
| R-MMU-210993 | Tie2 Signaling | IEA |
| R-MMU-2172127 | DAP12 interactions | IEA |
| R-MMU-2179392 | EGFR Transactivation by Gastrin | IEA |
| R-MMU-2404192 | Signaling by Type 1 Insulin-like Growth Factor 1 Receptor (IGF1R) | IEA |
| R-MMU-2424491 | DAP12 signaling | IEA |
| R-MMU-2428924 | IGF1R signaling cascade | IEA |
| R-MMU-2428928 | IRS-related events triggered by IGF1R | IEA |
| R-MMU-2428933 | SHC-related events triggered by IGF1R | IEA |
| R-MMU-2454202 | Fc epsilon receptor (FCERI) signaling | IEA |
| R-MMU-2730905 | Role of LAT2/NTAL/LAB on calcium mobilization | IEA |
| R-MMU-2871796 | FCERI mediated MAPK activation | IEA |
| R-MMU-2871809 | FCERI mediated Ca+2 mobilization | IEA |
| R-MMU-354192 | Integrin signaling | IEA |
| R-MMU-354194 | GRB2:SOS provides linkage to MAPK signaling for Integrins | IEA |
| R-MMU-372790 | Signaling by GPCR | IEA |
| R-MMU-375165 | NCAM signaling for neurite out-growth | IEA |
| R-MMU-388396 | GPCR downstream signalling | IEA |
| R-MMU-416476 | G alpha (q) signalling events | IEA |
| R-MMU-416482 | G alpha (12/13) signalling events | IEA |
| R-MMU-422475 | Axon guidance | IEA |
| R-MMU-449147 | Signaling by Interleukins | IEA |
| R-MMU-451927 | Interleukin-2 family signaling | IEA |
| R-MMU-512988 | Interleukin-3, Interleukin-5 and GM-CSF signaling | IEA |
| R-MMU-5654687 | Downstream signaling of activated FGFR1 | IEA |
| R-MMU-5654688 | SHC-mediated cascade:FGFR1 | IEA |
| R-MMU-5654693 | FRS-mediated FGFR1 signaling | IEA |
| R-MMU-5654696 | Downstream signaling of activated FGFR2 | IEA |
| R-MMU-5654699 | SHC-mediated cascade:FGFR2 | IEA |
| R-MMU-5654700 | FRS-mediated FGFR2 signaling | IEA |
| R-MMU-5654704 | SHC-mediated cascade:FGFR3 | IEA |
| R-MMU-5654706 | FRS-mediated FGFR3 signaling | IEA |
| R-MMU-5654708 | Downstream signaling of activated FGFR3 | IEA |
| R-MMU-5654712 | FRS-mediated FGFR4 signaling | IEA |
| R-MMU-5654716 | Downstream signaling of activated FGFR4 | IEA |
| R-MMU-5654719 | SHC-mediated cascade:FGFR4 | IEA |
| R-MMU-5654736 | Signaling by FGFR1 | IEA |
| R-MMU-5654738 | Signaling by FGFR2 | IEA |
| R-MMU-5654741 | Signaling by FGFR3 | IEA |
| R-MMU-5654743 | Signaling by FGFR4 | IEA |
| R-MMU-5673001 | RAF/MAP kinase cascade | IEA |
| R-MMU-5683057 | MAPK family signaling cascades | IEA |
| R-MMU-5684996 | MAPK1/MAPK3 signaling | IEA |
| R-MMU-6806834 | Signaling by MET | IEA |
| R-MMU-73887 | Death Receptor Signalling | IEA |
| R-MMU-74749 | Signal attenuation | IEA |
| R-MMU-74751 | Insulin receptor signalling cascade | IEA |
| R-MMU-74752 | Signaling by Insulin receptor | IEA |
| R-MMU-76002 | Platelet activation, signaling and aggregation | IEA |
| R-MMU-76009 | Platelet Aggregation (Plug Formation) | IEA |
| R-MMU-881907 | Gastrin-CREB signalling pathway via PKC and MAPK | IEA |
| R-MMU-8851805 | MET activates RAS signaling | IEA |
| R-MMU-8853659 | RET signaling | IEA |
| R-MMU-8983432 | Interleukin-15 signaling | IEA |
| R-MMU-9006115 | Signaling by NTRK2 (TRKB) | IEA |
| R-MMU-9006934 | Signaling by Receptor Tyrosine Kinases | IEA |
| R-MMU-9028731 | Activated NTRK2 signals through FRS2 and FRS3 | IEA |
| R-MMU-912526 | Interleukin receptor SHC signaling | IEA |
| R-MMU-9607240 | FLT3 Signaling | IEA |
| R-MMU-983695 | Antigen activates B Cell Receptor (BCR) leading to generation of second messengers | IEA |
| R-MMU-983705 | Signaling by the B Cell Receptor (BCR) | IEA |
| InterPro ID | InterPro Term |
|---|---|
| IPR035899 | DBL_dom_sf |
| IPR000219 | DH-domain |
| IPR009072 | Histone-fold |
| IPR007125 | Histone_H2A/H2B/H3 |
| IPR011993 | PH-like_dom_sf |
| IPR001849 | PH_domain |
| IPR008937 | Ras-like_GEF |
| IPR000651 | Ras-like_Gua-exchang_fac_N |
| IPR019804 | Ras_G-nucl-exch_fac_CS |
| IPR023578 | Ras_GEF_dom_sf |
| IPR001895 | RASGEF_cat_dom |
| IPR036964 | RASGEF_cat_dom_sf |