| Tag | Content |
|---|---|
| Uniprot ID | A0A452F6Z1 |
| Entrez ID | 102185660 |
| Genbank protein ID | |
| Genbank nucleotide ID | XM_018055149.1 |
| Ensembl protein ID | ENSCHIP00000020128 |
| Ensembl nucleotide ID | ENSCHIG00000018884 |
| Gene name | Uncharacterized protein |
| Gene symbol | SOS1 |
| Organism | Capra hircus |
| NCBI taxa ID | 9925 |
| Cleft type | |
| Developmental stage | |
| Data sources | Homology search |
| Reference | |
| Functional description | |
| Sequence | MQAQQLPYEF FSEENAPKWR GLLVPALKKV QGQVHPTLES SDDALQYVEE LILQLLNMLC 60 QAQPRSASDV EERVQKSFPH PIDKWAIADA QSAIEKRKRR NPLSLPVEKI HPLLKEVLGY 120 KIDHQVSVYI VAVLEYISAD ILKLVGNYVR NIRHYEITKQ DIKVAMCADK VLMDMFHQDV 180 EDINILSLTD EEPSTSGEQT YYDLVKAFMA EIRQYIRELN LIIKVFREPF VSNSKLFSAN 240 DVENIFSRIV DIHELSVKLL GHIEDTVEMT DEGSPHPLVG SCFEDLAEEL AFDPYESYAR 300 DILRPGFHDR FLSQLSKPGA ALYLQSIGEG FKEAVQYVLP RLLLAPVYHC LHYFELLKQL 360 EEKSEDQEDK ECLKQAITAL LNVQSGMEKI CSKSLAKRRL SESACRFYSQ QMKGKQLAIK 420 KMNEIQKNID GWEGKDIGQC CNEFIMEGTL TRVGAKHERH IFLFDGLMIC CKSNHGQPRL 480 PGASNAEYRL KEKFFMRKVQ INDKDDTSEY KHAFEIILKD ENSVIFSAKS AEEKNNWMAA 540 LISLQYRSTL ERMLDVTMLQ EEKEEQMRLP SADVYRFAEP DSEENIIFEE NVQPKAGIPI 600 IKAGTVIKLI ERLTYHMYAD PNFVRTFLTT YRSFCKPQEL LSLIIERFEI PEPEPTEADR 660 IAIENGDQPL SAELKRFRKE YIQPVQLRVL NVCRHWVEHH FYDFERDADL LQRMEEFIGT 720 VRGKAMKKWV ESITKIIQRK KIARDNGPGH NITFQSSPPT VEWHISRPGH IETFDLLTLH 780 PIEIARQLTL LESDLYRAVQ PSELVGSVWT KEDKEINSPN LLKMIRHTTN LTLWFEKCIV 840 ETENLEERVA VVSRIIEILQ VFQELNNFNG VLEVVSAMNS SPVYRLDHTF EQIPSRQKKI 900 LEEAHELSED HYKKYLAKLR SINPPCVPFF GIYLTNILKT EEGNPEVLKR HGKELINFSK 960 RRKVAEITGE IQQYQNQPYC LRVESDIKRF FENLNPMGNS MEKEFTDYLF NKSLEIEPRN 1020 PKPLPRFPKK YNYPLKSPGV RPSNPRPGTM RHPTPLQQEP RKISYSRIPE SETESTASAP 1080 NSPRTPLTPP PASGASSTTD VCSVFDSDHS SPFHSRSASV SSISLTKSTD EVPVPPPVPP 1140 RRRPESAPAE SSPSKMMSKH LDSPPAIPPR QPTSKAYSPR YSISDRTSIS DPPESPPLLP 1200 PREPVRTPDV FSSSPLHLQP PPLGKKSDHS NAFFPNSPSP FTPPPPQTPS PHGTRRHLPS 1260 PPLTQEVDLH SIAGPPVPPR QSTSQHIPKL PPKTYKREHT HPSMHRDGPP LLENAHSS 1318 |
Abbreviation :
CLO : cleft lip only. CPO : cleft palate only.
CLP : cleft lip and palate. CL/P : cleft lip with/without cleft palate.
For humans: CL/P, CLO, CPO, and CLP. For mice: CLO, CLP, and CPO.
| Relation | Gene symbol | Entrez ID | UniProt ID | Cleft type | Developmental stage | Species | Evidence | Details |
|---|---|---|---|---|---|---|---|---|
| 1:1 ortholog | SOS1 | 102185660 | A0A452F6Z1 | Capra hircus | Prediction | More>> | ||
| 1:1 ortholog | SOS1 | 100053889 | F6RQQ4 | Equus caballus | Prediction | More>> | ||
| 1:1 ortholog | SOS1 | 6654 | Q07889 | Homo sapiens | Prediction | More>> | ||
| 1:1 ortholog | Sos1 | 20662 | Q62245 | CPO | Mus musculus | Publication | More>> | |
| 1:1 ortholog | SOS1 | 459171 | A0A2I3T5C9 | Pan troglodytes | Prediction | More>> | ||
| 1:1 ortholog | Sos1 | 313845 | D4A3T0 | Rattus norvegicus | Prediction | More>> |
| GO ID | GO Term |
|---|---|
| GO:0005737 | cytoplasm |
| GO:0000786 | nucleosome |
| GO:0003677 | DNA binding |
| GO:0046982 | protein heterodimerization activity |
| GO:0005088 | Ras guanyl-nucleotide exchange factor activity |
| GO:0001782 | B cell homeostasis |
| GO:0048514 | blood vessel morphogenesis |
| GO:0003209 | cardiac atrium morphogenesis |
| GO:0007173 | epidermal growth factor receptor signaling pathway |
| GO:0061029 | eyelid development in camera-type eye |
| GO:0001942 | hair follicle development |
| GO:0061384 | heart trabecula morphogenesis |
| GO:1904693 | midbrain morphogenesis |
| GO:0035264 | multicellular organism growth |
| GO:0003344 | pericardium morphogenesis |
| GO:2000973 | regulation of pro-B cell differentiation |
| GO:0033081 | regulation of T cell differentiation in thymus |
| GO:0042129 | regulation of T cell proliferation |
| GO:0060021 | roof of mouth development |
| GO:0007264 | small GTPase mediated signal transduction |
| GO:0007296 | vitellogenesis |
| InterPro ID | InterPro Term |
|---|---|
| IPR035899 | DBL_dom_sf |
| IPR000219 | DH-domain |
| IPR009072 | Histone-fold |
| IPR007125 | Histone_H2A/H2B/H3 |
| IPR011993 | PH-like_dom_sf |
| IPR001849 | PH_domain |
| IPR008937 | Ras-like_GEF |
| IPR000651 | Ras-like_Gua-exchang_fac_N |
| IPR019804 | Ras_G-nucl-exch_fac_CS |
| IPR023578 | Ras_GEF_dom_sf |
| IPR001895 | RASGEF_cat_dom |
| IPR036964 | RASGEF_cat_dom_sf |