| Tag | Content |
|---|---|
| Uniprot ID | D4A3T0 |
| Entrez ID | 313845 |
| Genbank protein ID | EDM02758.1 |
| Genbank nucleotide ID | NM_001100716.1 |
| Ensembl protein ID | ENSRNOP00000009359 |
| Ensembl nucleotide ID | ENSRNOG00000007106 |
| Gene name | SOS Ras/Rac guanine nucleotide exchange factor 1 |
| Gene symbol | Sos1 |
| Organism | Rattus norvegicus |
| NCBI taxa ID | 10116 |
| Cleft type | |
| Developmental stage | |
| Data sources | Homology search |
| Reference | |
| Functional description | |
| Sequence | MQAQQLPYEF FSEENAPKWR GLLVPALKKV QGQVHPTLES NEDALQYVEE LILQLLNMLC 60 QAQPRSASDV EERVQKSFPH PIDKWAIADA QSAIEKRKRR NPLSLPAERI HHLLREVLGY 120 KIDHQVSVYI VAVLEYISAD ILKLVGNYVR NIRHYEITKQ DIKVAMCADK VLMDMFHQDV 180 EDINILSLTD EEPSTSGEQT YYDLVKAFMA EIRQYIRELN LIIKVFREPF VSNSKLFSSY 240 DVENIFSRIV DIHELSVKLL GHIEDTVEMT DEGSPHPLVG SCFEDLAEEL AFDPYESYAR 300 DVLRPGFHER FLSQLSKPGA ALYLQSIGEG FKEAVQYVLP RLLLAPVYHC LHYFELLKQL 360 EEKSEDQEDK ECMKQAITAL LNVQSGMEKI CSKNLAKRRL SESACRFYSQ QMKGKQLAIK 420 KMNEIQKNID GWEGKDIGQC CNEFIMEGTL TRVGAKHERH IFLFDGLMIC CKSNHGQPRL 480 PGASNAEYRL KEKFFMRKVQ INDKDDTSEY KHAFEIILKD GNSVIFSAKS AEEKNNWMAA 540 LISLQYRSTL ERMLDVTMLQ EEKEEHMRLP SADVYRFAEP DSEENILFEE NVQPKAGIPI 600 IKAGTVVKLI ERLTYHMYAD PNFVRTFLTT YRSFCKPQEL LNLLIERFEI PEPEPTEADR 660 IAIENGDQPL SAELKRFRKE YIQPVQLRVL NVCRHWVEHH FYDFERDVDL LQRMEEFIGT 720 VRGKAMKKWV ESITKIIQRK KIARDNGPGH NITFQNSPPT VEWHISRPGH IETFDLLTLH 780 PIEIARQLTL LESDLYRAVQ PSELVGSVWT KEDKEINSPN LLKMIRHTTN LTLWFEKCIV 840 ETENLEERVA VVSRIIEILQ VFQELNNFNG VLEVVSAMNS SPVYRLDHTF EQIPSRQKKI 900 LEEAHELSED HYKKYLAKLR SINPPCVPFF GIYLTNILKT EEGNPEVLRR HGKELINFSK 960 RRRVAEITGE IQQYQNQPYC LRVESDIKRF FENLNPMGNS MEKEFTDYLF NKSLEIEPRN 1020 PKPLPRFPKK YSYPLKSPGV RPSNPRPGTM RHPTPLQQEP RKISYSRIPE SETESTASAP 1080 NSPRTPLTPP PASSASSNTD VCSVFDSDHS ASPFHSRSAS VSSISLSKGT EEVPVPPPVP 1140 PRRRPESAPA ESSPSKIMSK HLDSPPAIPP RQPTSKAYSP RYSISDRTSI SDPPESPPLL 1200 PPREPVRTPD VFSSSPLHLQ PPPLGKKSDH GNAFFPNSPS PFTPPPPQTP SPHGTRRHLP 1260 SPPLTQEVDL HSIAGPPVPP RQSTSQLIPK LPPKTYKREH THPSMHRDGP PLLENAHSS 1319 |
Abbreviation :
CLO : cleft lip only. CPO : cleft palate only.
CLP : cleft lip and palate. CL/P : cleft lip with/without cleft palate.
For humans: CL/P, CLO, CPO, and CLP. For mice: CLO, CLP, and CPO.
| Relation | Gene symbol | Entrez ID | UniProt ID | Cleft type | Developmental stage | Species | Evidence | Details |
|---|---|---|---|---|---|---|---|---|
| 1:1 ortholog | SOS1 | 102185660 | A0A452F6Z1 | Capra hircus | Prediction | More>> | ||
| 1:1 ortholog | SOS1 | 100053889 | F6RQQ4 | Equus caballus | Prediction | More>> | ||
| 1:1 ortholog | SOS1 | 6654 | Q07889 | Homo sapiens | Prediction | More>> | ||
| 1:1 ortholog | Sos1 | 20662 | Q62245 | CPO | Mus musculus | Publication | More>> | |
| 1:1 ortholog | SOS1 | 459171 | A0A2I3T5C9 | Pan troglodytes | Prediction | More>> | ||
| 1:1 ortholog | Sos1 | 313845 | D4A3T0 | Rattus norvegicus | Prediction | More>> |
| GO ID | GO Term |
|---|---|
| GO:0005737 | cytoplasm |
| GO:0005829 | cytosol |
| GO:0043025 | neuronal cell body |
| GO:0000786 | nucleosome |
| GO:0005886 | plasma membrane |
| GO:0014069 | postsynaptic density |
| GO:0003677 | DNA binding |
| GO:0005085 | guanyl-nucleotide exchange factor activity |
| GO:0046982 | protein heterodimerization activity |
| GO:0005088 | Ras guanyl-nucleotide exchange factor activity |
| GO:0017124 | SH3 domain binding |
| GO:0001782 | B cell homeostasis |
| GO:0048514 | blood vessel morphogenesis |
| GO:0003209 | cardiac atrium morphogenesis |
| GO:0007173 | epidermal growth factor receptor signaling pathway |
| GO:0061029 | eyelid development in camera-type eye |
| GO:0008543 | fibroblast growth factor receptor signaling pathway |
| GO:0001942 | hair follicle development |
| GO:0003007 | heart morphogenesis |
| GO:0061384 | heart trabecula morphogenesis |
| GO:0002260 | lymphocyte homeostasis |
| GO:1904693 | midbrain morphogenesis |
| GO:0035264 | multicellular organism growth |
| GO:0048011 | neurotrophin TRK receptor signaling pathway |
| GO:0003344 | pericardium morphogenesis |
| GO:0045742 | positive regulation of epidermal growth factor receptor signaling pathway |
| GO:0051057 | positive regulation of small GTPase mediated signal transduction |
| GO:0007265 | Ras protein signal transduction |
| GO:2000973 | regulation of pro-B cell differentiation |
| GO:0033081 | regulation of T cell differentiation in thymus |
| GO:0042129 | regulation of T cell proliferation |
| GO:0060021 | roof of mouth development |
| GO:0007264 | small GTPase mediated signal transduction |
| GO:0007296 | vitellogenesis |
| InterPro ID | InterPro Term |
|---|---|
| IPR035899 | DBL_dom_sf |
| IPR000219 | DH-domain |
| IPR009072 | Histone-fold |
| IPR007125 | Histone_H2A/H2B/H3 |
| IPR011993 | PH-like_dom_sf |
| IPR001849 | PH_domain |
| IPR008937 | Ras-like_GEF |
| IPR000651 | Ras-like_Gua-exchang_fac_N |
| IPR019804 | Ras_G-nucl-exch_fac_CS |
| IPR023578 | Ras_GEF_dom_sf |
| IPR001895 | RASGEF_cat_dom |
| IPR036964 | RASGEF_cat_dom_sf |