| Tag | Content |
|---|---|
| Uniprot ID | A0A2I3T7H8; A0A2J8MY88; |
| Entrez ID | 740308 |
| Genbank protein ID | JAA08708.1; JAA13894.1; JAA36306.1; JAA25769.1; |
| Genbank nucleotide ID | XM_001154426.4 |
| Ensembl protein ID | ENSPTRP00000084833 |
| Ensembl nucleotide ID | ENSPTRG00000023749 |
| Gene name | T-box 3 |
| Gene symbol | TBX3 |
| Organism | Pan troglodytes |
| NCBI taxa ID | 9598 |
| Cleft type | |
| Developmental stage | |
| Data sources | Homology search |
| Reference | |
| Functional description | |
| Sequence | MSLSMRDPVI PGTSMAYHPF LPHRAPDFAM SAVLGHQPPF FPALTLPPNG AAALSLPGAL 60 AKPIMDQLVG AAETGIPFSS LGPQAHLRPL KTMEPEEEVE DDPKVHLEAK ELWDQFHKRG 120 TEMVITKSGR RMFPPFKVRC SGLDKKAKYI LLMDIIAADD CRYKFHNSRW MVAGKADPEM 180 PKRMYIHPDS PATGEQWMSK VVTFHKLKLT NNISDKHGFT LAFPSDHATW QGNYSFGTQT 240 ILNSMHKYQP RFHIVRANDI LKLPYSTFRT YLFPETEFIA VTAYQNDKIT QLKIDNNPFA 300 KGFRDTGNGR REKRKQLTLQ SMRVFDERHK KENGTSDESS SEQAAFNCFA QASSPAVSTV 360 GTSNLKDLCP SEGESDAEAE SKEEHGPEAC DAAKISTTTS EEPCRDKGSP AVKAHLFAAE 420 RPRDSGRLDK ASPDSRHSPA TISSSTRGLG AEERRSPVRE GTAPAKVEEA RALPGKEAFA 480 PLTVQTDAAA AHLAQGPLPG LGFAPGLAGQ QFFNGHPLFL HPSQFAMGGA FSSMAAAGMG 540 PLLATVSGAS TGVSGLDSTA MASAAAAQGL SGASAATLPF HLQQHVLASQ GLAMSPFGSL 600 FPYPYTYMAA AAAASSAAAS SSVHRHPFLN LNTMRPRLRY SPYSIPVPVP DGSSLLTTAL 660 PSMAAAAGPL DGKVAALAAS PASVAVDSGS ELNSRSSTLS SSSVSLSPKL CAEKEAATSE 720 LQSIQRLVSG LEAKPDRSRS ASP 743 |
Abbreviation :
CLO : cleft lip only. CPO : cleft palate only.
CLP : cleft lip and palate. CL/P : cleft lip with/without cleft palate.
For humans: CL/P, CLO, CPO, and CLP. For mice: CLO, CLP, and CPO.
| Relation | Gene symbol | Entrez ID | UniProt ID | Cleft type | Developmental stage | Species | Evidence | Details |
|---|---|---|---|---|---|---|---|---|
| 1:1 ortholog | TBX3 | 102185207 | A0A452EBG9 | Capra hircus | Prediction | More>> | ||
| 1:1 ortholog | TBX3 | 6926 | O15119 | Homo sapiens | Prediction | More>> | ||
| 1:1 ortholog | Tbx3 | 21386 | P70324 | CPO | Mus musculus | Publication | More>> | |
| 1:1 ortholog | TBX3 | 740308 | A0A2I3T7H8 | Pan troglodytes | Prediction | More>> | ||
| 1:1 ortholog | Tbx3 | 353305 | Q7TST9 | Rattus norvegicus | Prediction | More>> | ||
| 1:1 ortholog | tbx3a | 556870 | B8JKS6 | Danio rerio | Prediction | More>> |
| GO ID | GO Term |
|---|---|
| GO:0005634 | nucleus |
| GO:0001228 | DNA-binding transcription activator activity, RNA polymerase II-specific |
| GO:0001227 | DNA-binding transcription repressor activity, RNA polymerase II-specific |
| GO:0001102 | RNA polymerase II activating transcription factor binding |
| GO:0000978 | RNA polymerase II cis-regulatory region sequence-specific DNA binding |
| GO:0000977 | RNA polymerase II regulatory region sequence-specific DNA binding |
| GO:0001085 | RNA polymerase II transcription factor binding |
| GO:0008595 | anterior/posterior axis specification, embryo |
| GO:0003167 | atrioventricular bundle cell differentiation |
| GO:0001568 | blood vessel development |
| GO:0060444 | branching involved in mammary gland duct morphogenesis |
| GO:0003205 | cardiac chamber development |
| GO:0060923 | cardiac muscle cell fate commitment |
| GO:0001708 | cell fate specification |
| GO:0090398 | cellular senescence |
| GO:0007417 | central nervous system development |
| GO:0042733 | embryonic digit morphogenesis |
| GO:0035115 | embryonic forelimb morphogenesis |
| GO:0035116 | embryonic hindlimb morphogenesis |
| GO:0030540 | female genitalia development |
| GO:0046884 | follicle-stimulating hormone secretion |
| GO:0001947 | heart looping |
| GO:0001701 | in utero embryonic development |
| GO:0021761 | limbic system development |
| GO:0032275 | luteinizing hormone secretion |
| GO:0030539 | male genitalia development |
| GO:0060596 | mammary placode formation |
| GO:0048332 | mesoderm morphogenesis |
| GO:0043066 | negative regulation of apoptotic process |
| GO:0030857 | negative regulation of epithelial cell differentiation |
| GO:0045662 | negative regulation of myoblast differentiation |
| GO:0000122 | negative regulation of transcription by RNA polymerase II |
| GO:0003151 | outflow tract morphogenesis |
| GO:0045787 | positive regulation of cell cycle |
| GO:0008284 | positive regulation of cell population proliferation |
| GO:2000648 | positive regulation of stem cell proliferation |
| GO:0045944 | positive regulation of transcription by RNA polymerase II |
| GO:0060021 | roof of mouth development |
| GO:0060931 | sinoatrial node cell development |
| GO:0001501 | skeletal system development |
| GO:0010159 | specification of animal organ position |
| GO:0019827 | stem cell population maintenance |
| GO:0060412 | ventricular septum morphogenesis |