| Tag | Content |
|---|---|
| Uniprot ID | Q7TST9 |
| Entrez ID | 353305 |
| Genbank protein ID | AAP43504.1 |
| Genbank nucleotide ID | XM_006249415.2; XM_006249416.3; NM_181638.1; XM_006249417.3; |
| Ensembl protein ID | ENSRNOP00000011552 |
| Ensembl nucleotide ID | ENSRNOG00000008706 |
| Gene name | T-box transcription factor TBX3 |
| Gene symbol | Tbx3 |
| Organism | Rattus norvegicus |
| NCBI taxa ID | 10116 |
| Cleft type | |
| Developmental stage | |
| Data sources | Homology search |
| Reference | |
| Functional description | Transcriptional repressor involved in developmental processes. Probably plays a role in limb pattern formation. Acts as a negative regulator of PML function in cellular senescence (By similarity). |
| Sequence | MSLSMRDPVI PGTSMAYHPF LPHRAPDFAM SAVLGHQPPF FPALTLPPNG AAALSLPGAL 60 AKPIMDQLVG AAETGIPFSS LGPQAHLRPL KTMEPEEDVE DDPKVHLEAK ELWDQFHKRG 120 TEMVITKSGR RMFPPFKVRC SGLDKKAKYI LLMDIIAADD CRYKFHNSRW MVAGKADPEM 180 PKRMYIHPDS PATGEQWMSK VVTFHKLKLT NNISDKHGFT LAFPSDHATW QGNYSFGTQT 240 ILNSMHKYQP RFHIVRANDI LKLPYSTFRT YLFPETEFIA VTAYQNDKIT QLKIDNNPFA 300 KGFRDTGNGR REKRKQLTLQ SMRVFDERHK KETGTSDESS SEQAAFNCFA QASSPAVSTV 360 GTSNLKDLCP SEAESDAEAE SKEEHGPEAC DTAKISTTTA EEPGRDKGSP ATRAQLFPAE 420 PSRARDTARL DKASPDSRHS PATISSSTRV PGADEHRSPG REGPVSAKVD EARALPAKDA 480 FAPLSVQTDA TAHLTQGPLP GLGFAPGLAG QQFFNGHPLF LHPGQFAMGG AFSSMAAGMG 540 PLLATVSGAS TGVSGLDSTA MASAAAAQGL SGASAATLPF HLQQHVLASQ GLAMSPFGSL 600 FPYPYTYMAA AAAASSAAAS SSVHRHPFLN LNSMRPRLRY SPYSIPVPVP DSSSLLATAL 660 PSMASAAGPL DGKSAVLAAS PASVAVDSGS ELNSRSSTLS SGSVSLSPKL CSEKEAATSE 720 LQSIQRLVSG LEAKPDRSCS GSP 743 |
Abbreviation :
CLO : cleft lip only. CPO : cleft palate only.
CLP : cleft lip and palate. CL/P : cleft lip with/without cleft palate.
For humans: CL/P, CLO, CPO, and CLP. For mice: CLO, CLP, and CPO.
| Relation | Gene symbol | Entrez ID | UniProt ID | Cleft type | Developmental stage | Species | Evidence | Details |
|---|---|---|---|---|---|---|---|---|
| 1:1 ortholog | TBX3 | 102185207 | A0A452EBG9 | Capra hircus | Prediction | More>> | ||
| 1:1 ortholog | TBX3 | 6926 | O15119 | Homo sapiens | Prediction | More>> | ||
| 1:1 ortholog | Tbx3 | 21386 | P70324 | CPO | Mus musculus | Publication | More>> | |
| 1:1 ortholog | TBX3 | 740308 | A0A2I3T7H8 | Pan troglodytes | Prediction | More>> | ||
| 1:1 ortholog | Tbx3 | 353305 | Q7TST9 | Rattus norvegicus | Prediction | More>> | ||
| 1:1 ortholog | tbx3a | 556870 | B8JKS6 | Danio rerio | Prediction | More>> |
| GO ID | GO Term |
|---|---|
| GO:0005634 | nucleus |
| GO:0005667 | transcription factor complex |
| GO:0001228 | DNA-binding transcription activator activity, RNA polymerase II-specific |
| GO:0003700 | DNA-binding transcription factor activity |
| GO:0001227 | DNA-binding transcription repressor activity, RNA polymerase II-specific |
| GO:0001102 | RNA polymerase II activating transcription factor binding |
| GO:0000978 | RNA polymerase II cis-regulatory region sequence-specific DNA binding |
| GO:0000977 | RNA polymerase II regulatory region sequence-specific DNA binding |
| GO:0001085 | RNA polymerase II transcription factor binding |
| GO:0043565 | sequence-specific DNA binding |
| GO:0009887 | animal organ morphogenesis |
| GO:0008595 | anterior/posterior axis specification, embryo |
| GO:0003167 | atrioventricular bundle cell differentiation |
| GO:0001568 | blood vessel development |
| GO:0060444 | branching involved in mammary gland duct morphogenesis |
| GO:0003205 | cardiac chamber development |
| GO:0055007 | cardiac muscle cell differentiation |
| GO:0060923 | cardiac muscle cell fate commitment |
| GO:0007569 | cell aging |
| GO:0001708 | cell fate specification |
| GO:0090398 | cellular senescence |
| GO:0007417 | central nervous system development |
| GO:0042733 | embryonic digit morphogenesis |
| GO:0035115 | embryonic forelimb morphogenesis |
| GO:0035050 | embryonic heart tube development |
| GO:0035116 | embryonic hindlimb morphogenesis |
| GO:0030540 | female genitalia development |
| GO:0046884 | follicle-stimulating hormone secretion |
| GO:0035136 | forelimb morphogenesis |
| GO:0001947 | heart looping |
| GO:0003007 | heart morphogenesis |
| GO:0001701 | in utero embryonic development |
| GO:0035108 | limb morphogenesis |
| GO:0021761 | limbic system development |
| GO:0032275 | luteinizing hormone secretion |
| GO:0030539 | male genitalia development |
| GO:0030879 | mammary gland development |
| GO:0060596 | mammary placode formation |
| GO:0048332 | mesoderm morphogenesis |
| GO:0043066 | negative regulation of apoptotic process |
| GO:0030857 | negative regulation of epithelial cell differentiation |
| GO:0045662 | negative regulation of myoblast differentiation |
| GO:0000122 | negative regulation of transcription by RNA polymerase II |
| GO:0045892 | negative regulation of transcription, DNA-templated |
| GO:0003151 | outflow tract morphogenesis |
| GO:0045787 | positive regulation of cell cycle |
| GO:0008284 | positive regulation of cell population proliferation |
| GO:2000648 | positive regulation of stem cell proliferation |
| GO:0045944 | positive regulation of transcription by RNA polymerase II |
| GO:0045893 | positive regulation of transcription, DNA-templated |
| GO:0042127 | regulation of cell population proliferation |
| GO:0060021 | roof of mouth development |
| GO:0060931 | sinoatrial node cell development |
| GO:0001501 | skeletal system development |
| GO:0010159 | specification of animal organ position |
| GO:0019827 | stem cell population maintenance |
| GO:0060412 | ventricular septum morphogenesis |