| Tag | Content |
|---|---|
| Uniprot ID | A0A452EBG9 |
| Entrez ID | 102185207 |
| Genbank protein ID | |
| Genbank nucleotide ID | XM_018061190.1 |
| Ensembl protein ID | ENSCHIP00000009495 |
| Ensembl nucleotide ID | ENSCHIG00000012328 |
| Gene name | TBX domain-containing protein |
| Gene symbol | TBX3 |
| Organism | Capra hircus |
| NCBI taxa ID | 9925 |
| Cleft type | |
| Developmental stage | |
| Data sources | Homology search |
| Reference | |
| Functional description | |
| Sequence | MSLSMRDPVI PGTSMAYHPF LPHRAPDFAM SAVLGHQPPF FPALTLPPNG AAALSLPGAL 60 AKPIMDQLVG AAETGIPFSS LGPQTHLRPL KTMEPEEEVE DDPKVHLEAK ELWDQFHKRG 120 TEMVITKSGR RMFPPFKVRC SGLDKKAKYI LLMDIIAADD CRYKFHNSRW MVAGKADPEM 180 PKRMYIHPDS PATGEQWMSK VVTFHKLKLT NNISDKHGFT LAFPSDQATW QGNYSFGTQT 240 ILNSMHKYQP RFHIVRANDI LKLPYSTFRT YLFPETEFIA VTAYQNDKIT QLKIDNNPFA 300 KGFRDTGNGR REKRKQLTLQ SMRVFDDRHK KENGTSDESS SEQAAFNCFA QSSSPAVSTV 360 GTSNLKDLCP SEGESDAEAD SKEEHGPEAC DAAKISTTTS EDPCRDKGSP AVKPHLFAAE 420 PGGRPRDSGR LDKASPDSRH SPATISSSTR GLGAEERRSP GRDSAATSKA AEEARVLPGK 480 EAFAPLTVQT DPAAAHLGQG PLPGLGFAPG LAGQQFFNGH PLFLHPGQFA MGGAFSSMAA 540 GMGPLLATVS GASTGVSGLD STAMASAAAA QGLSGASATL PFHLQQHVLA SQGLAMSPFG 600 SLFPYPYTYM AAAAAASSAA ASSSVHRHPF LNLNTMRPRL RYSPYSIPLP VPDGSGLLTT 660 ALPSMAAAAA AAAGPLDGKA AALAASPASV AVDSGSELNS RSSTLSSSSV SLSPKLCPEK 720 EAATSELQNI QRLVSGLEAK PDRSRSASP 749 |
Abbreviation :
CLO : cleft lip only. CPO : cleft palate only.
CLP : cleft lip and palate. CL/P : cleft lip with/without cleft palate.
For humans: CL/P, CLO, CPO, and CLP. For mice: CLO, CLP, and CPO.
| Relation | Gene symbol | Entrez ID | UniProt ID | Cleft type | Developmental stage | Species | Evidence | Details |
|---|---|---|---|---|---|---|---|---|
| 1:1 ortholog | TBX3 | 102185207 | A0A452EBG9 | Capra hircus | Prediction | More>> | ||
| 1:1 ortholog | TBX3 | 6926 | O15119 | Homo sapiens | Prediction | More>> | ||
| 1:1 ortholog | Tbx3 | 21386 | P70324 | CPO | Mus musculus | Publication | More>> | |
| 1:1 ortholog | TBX3 | 740308 | A0A2I3T7H8 | Pan troglodytes | Prediction | More>> | ||
| 1:1 ortholog | Tbx3 | 353305 | Q7TST9 | Rattus norvegicus | Prediction | More>> | ||
| 1:1 ortholog | tbx3a | 556870 | B8JKS6 | Danio rerio | Prediction | More>> |
| GO ID | GO Term |
|---|---|
| GO:0005634 | nucleus |
| GO:0001227 | DNA-binding transcription repressor activity, RNA polymerase II-specific |
| GO:0001102 | RNA polymerase II activating transcription factor binding |
| GO:0000978 | RNA polymerase II cis-regulatory region sequence-specific DNA binding |
| GO:0001085 | RNA polymerase II transcription factor binding |
| GO:0008595 | anterior/posterior axis specification, embryo |
| GO:0003167 | atrioventricular bundle cell differentiation |
| GO:0001568 | blood vessel development |
| GO:0060444 | branching involved in mammary gland duct morphogenesis |
| GO:0060923 | cardiac muscle cell fate commitment |
| GO:0090398 | cellular senescence |
| GO:0042733 | embryonic digit morphogenesis |
| GO:0035115 | embryonic forelimb morphogenesis |
| GO:0035116 | embryonic hindlimb morphogenesis |
| GO:0030540 | female genitalia development |
| GO:0046884 | follicle-stimulating hormone secretion |
| GO:0001947 | heart looping |
| GO:0001701 | in utero embryonic development |
| GO:0021761 | limbic system development |
| GO:0032275 | luteinizing hormone secretion |
| GO:0030539 | male genitalia development |
| GO:0060596 | mammary placode formation |
| GO:0048332 | mesoderm morphogenesis |
| GO:0043066 | negative regulation of apoptotic process |
| GO:0030857 | negative regulation of epithelial cell differentiation |
| GO:0045662 | negative regulation of myoblast differentiation |
| GO:0003151 | outflow tract morphogenesis |
| GO:0045787 | positive regulation of cell cycle |
| GO:2000648 | positive regulation of stem cell proliferation |
| GO:0045893 | positive regulation of transcription, DNA-templated |
| GO:0060021 | roof of mouth development |
| GO:0060931 | sinoatrial node cell development |
| GO:0001501 | skeletal system development |
| GO:0010159 | specification of animal organ position |
| GO:0019827 | stem cell population maintenance |
| GO:0060412 | ventricular septum morphogenesis |