| Tag | Content |
|---|---|
| Uniprot ID | A0A2I3TGC8 |
| Entrez ID | 737730 |
| Genbank protein ID | |
| Genbank nucleotide ID | XM_016948437.1 |
| Ensembl protein ID | ENSPTRP00000087912 |
| Ensembl nucleotide ID | ENSPTRG00000046058 |
| Gene name | 3-hydroxyanthranilate 3,4-dioxygenase |
| Gene symbol | HAAO |
| Organism | Pan troglodytes |
| NCBI taxa ID | 9598 |
| Cleft type | |
| Developmental stage | |
| Data sources | Homology search |
| Reference | |
| Functional description | Catalyzes the oxidative ring opening of 3-hydroxyanthranilate to 2-amino-3-carboxymuconate semialdehyde, which spontaneously cyclizes to quinolinate. |
| Sequence | MERRVGVRAW VEENRGSFQP PVCNKLMHQE QLKVMFVGGP NTRKDYHIEE GEEVFYQLEG 60 DMVLRVLEQG KHRDVVIRQG EIFLLPARVP HSPQRFANTV GLVVERRRLE TELDGLRYYV 120 GDTMDVLFEK WFYCKDLGTQ LAPIIQEFFS SEQYRTGKPI PDQLLKEPPF PLSTRSIMEP 180 MSLDAWLDSH HRELQAGTPL SLFGDTYETQ VIAYGQGSSE GMRQNVDVWL WQLEGSSVVT 240 MGGRRLSLAP DDSLLVLAGT SYAWERTQGS VALSVTQDPA CKKPLR 286 |
Abbreviation :
CLO : cleft lip only. CPO : cleft palate only.
CLP : cleft lip and palate. CL/P : cleft lip with/without cleft palate.
For humans: CL/P, CLO, CPO, and CLP. For mice: CLO, CLP, and CPO.
| Relation | Gene symbol | Entrez ID | UniProt ID | Cleft type | Developmental stage | Species | Evidence | Details |
|---|---|---|---|---|---|---|---|---|
| 1:1 ortholog | HAAO | 510602 | Q0VCA8 | Bos taurus | Prediction | More>> | ||
| 1:1 ortholog | HAAO | 102187775 | A0A452EKB2 | Capra hircus | Prediction | More>> | ||
| 1:1 ortholog | HAAO | 23498 | P46952 | Homo sapiens | Prediction | More>> | ||
| 1:1 ortholog | Haao | 107766 | Q78JT3 | CPO | Mus musculus | Publication | More>> | |
| 1:1 ortholog | HAAO | 737730 | A0A2I3TGC8 | Pan troglodytes | Prediction | More>> | ||
| 1:1 ortholog | HAAO | G1TAA6 | Oryctolagus cuniculus | Prediction | More>> | |||
| 1:1 ortholog | Haao | A0A0G2JSV5 | Rattus norvegicus | Prediction | More>> | |||
| 1:1 ortholog | haao | 492518 | F1QYC7 | Danio rerio | Prediction | More>> |
| GO ID | GO Term |
|---|---|
| GO:0005623 | cell |
| GO:0005737 | cytoplasm |
| GO:0005829 | cytosol |
| GO:0000334 | 3-hydroxyanthranilate 3,4-dioxygenase activity |
| GO:0008198 | ferrous iron binding |
| GO:0034354 | 'de novo' NAD biosynthetic process from tryptophan |
| GO:0043420 | anthranilate metabolic process |
| GO:0070050 | neuron cellular homeostasis |
| GO:0019805 | quinolinate biosynthetic process |
| GO:0046874 | quinolinate metabolic process |
| GO:0046686 | response to cadmium ion |
| GO:0010043 | response to zinc ion |
| GO:0006569 | tryptophan catabolic process |
| Pfam ID | Pfam Term |
|---|---|
| PF06052 | 3-HAO |