Gene: Haao

Basic information

Tag Content
Uniprot ID Q78JT3; Q52L88;
Entrez ID 107766
Genbank protein ID AAH12872.1; AAH94021.1;
Genbank nucleotide ID NM_025325.2; XM_006523463.3;
Ensembl protein ID ENSMUSP00000000687
Ensembl nucleotide ID ENSMUSG00000000673
Gene name 3-hydroxyanthranilate 3,4-dioxygenase
Gene symbol Haao
Organism Mus musculus
NCBI taxa ID 10090
Cleft type CPO
Developmental stage
Data sources Manually collected
Reference 28792876
Functional description Catalyzes the oxidative ring opening of 3-hydroxyanthranilate to 2-amino-3-carboxymuconate semialdehyde, which spontaneously cyclizes to quinolinate.
Sequence
MERRVRVKSW VEENRASFQP PVCNKLMHQE QLKIMFVGGP NTRKDYHIEE GEEVFYQLEG 60
DMILRVLEQG QHRDVPIRQG EIFLLPARVP HSPQRFANTM GLVIERRRLE SELDGLRYYV 120
GDTEDVLFEK WFHCKDLGTQ LAPIIQEFFH SEQYRTGKPN PDQLLKELPF PLNTRSIMKP 180
MSLKAWLDGH SRELQAGTSL SLFGDSYETQ VIAHGQGSSK GPRQDVDVWL WQQEGSSKVT 240
MGGQCIALAP DDSLLVPAGT SYVWERAQGS VALSVTQDPA RKKPWW 286

Abbreviation :
CLO : cleft lip only. CPO : cleft palate only. CLP : cleft lip and palate. CL/P : cleft lip with/without cleft palate.
For humans: CL/P, CLO, CPO, and CLP. For mice: CLO, CLP, and CPO.

Protein structural annotations

3D structure in PDB database

There is no related protein structure for this gene.

Protein disorder information

Orthologous information

Relation Gene symbol Entrez ID UniProt ID Cleft type Developmental stage Species Evidence Details
1:1 orthologHAAO510602Q0VCA8Bos taurusPredictionMore>>
1:1 orthologHAAO102187775A0A452EKB2Capra hircusPredictionMore>>
1:1 orthologHAAO23498P46952Homo sapiensPredictionMore>>
1:1 orthologHaao107766Q78JT3CPOMus musculusPublicationMore>>
1:1 orthologHAAO737730A0A2I3TGC8Pan troglodytesPredictionMore>>
1:1 orthologHAAOG1TAA6Oryctolagus cuniculusPredictionMore>>
1:1 orthologHaaoA0A0G2JSV5Rattus norvegicusPredictionMore>>
1:1 orthologhaao492518F1QYC7Danio rerioPredictionMore>>

Other genetic variants/mutations

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Gene Ontology (GO)/biological pathways

GO:Molecular Function

GO ID GO Term Evidence
GO:0000334 3-hydroxyanthranilate 3,4-dioxygenase activityISO
GO:0000334 3-hydroxyanthranilate 3,4-dioxygenase activityIDA
GO:0000334 3-hydroxyanthranilate 3,4-dioxygenase activityIBA
GO:0005506 iron ion bindingISO
GO:0008198 ferrous iron bindingISS
GO:0008198 ferrous iron bindingISO
GO:0019825 oxygen bindingISO

GO:Biological Process

GO ID GO Term Evidence
GO:0006569 tryptophan catabolic processIEA
GO:0009435 NAD biosynthetic processISS
GO:0009435 NAD biosynthetic processISO
GO:0010043 response to zinc ionISO
GO:0019805 quinolinate biosynthetic processISS
GO:0019805 quinolinate biosynthetic processISO
GO:0034354 'de novo' NAD biosynthetic process from tryptophanIBA
GO:0043420 anthranilate metabolic processIEA
GO:0046686 response to cadmium ionISO
GO:0046874 quinolinate metabolic processISO
GO:0046874 quinolinate metabolic processIBA
GO:0055114 oxidation-reduction processIEA
GO:0070050 neuron cellular homeostasisISO

GO:Cellular Component

GO ID GO Term Evidence
GO:0005623 cellIEA
GO:0005737 cytoplasmISO
GO:0005737 cytoplasmIBA
GO:0005829 cytosolISO
GO:0031966 mitochondrial membraneISO

Reactome Pathway

Reactome ID Reactome Term Evidence
R-MMU-1430728 MetabolismIEA
R-MMU-71240 Tryptophan catabolismIEA
R-MMU-71291 Metabolism of amino acids and derivativesIEA

Functional annotations

Keywords

Keyword ID Keyword Term
KW-0963 Cytoplasm
KW-0223 Dioxygenase
KW-0408 Iron
KW-0479 Metal-binding
KW-0560 Oxidoreductase
KW-0662 Pyridine nucleotide biosynthesis
KW-1185 Reference proteome

Interpro

InterPro ID InterPro Term
IPR010329 3hydroanth_dOase
IPR016700 3hydroanth_dOase_met
IPR014710 RmlC-like_jellyroll
IPR011051 RmlC_Cupin_sf

PROSITE

PROSITE ID PROSITE Term

Pfam

Pfam ID Pfam Term
PF06052 3-HAO

Protein-miRNA interaction