| Tag | Content |
|---|---|
| Uniprot ID | G1TAA6 |
| Entrez ID | |
| Genbank protein ID | |
| Genbank nucleotide ID | |
| Ensembl protein ID | ENSOCUP00000013594 |
| Ensembl nucleotide ID | ENSOCUG00000015827 |
| Gene name | 3-hydroxyanthranilate 3,4-dioxygenase |
| Gene symbol | HAAO |
| Organism | Oryctolagus cuniculus |
| NCBI taxa ID | 9986 |
| Cleft type | |
| Developmental stage | |
| Data sources | Homology search |
| Reference | |
| Functional description | Catalyzes the oxidative ring opening of 3-hydroxyanthranilate to 2-amino-3-carboxymuconate semialdehyde, which spontaneously cyclizes to quinolinate. |
| Sequence | MRLVEKAAGG HGAGRAPPTA EREDAARRGR LAEDARAAGM ERPVRVRTWV RENRASFQPP 60 VCNKLLHQEQ LKIMFVGGPN TRKDYHIEEG EEVFYQLEGD MVLRVLERGQ HRDVVIRQGE 120 IFLLPARVPH SPQRFANTVG LVIERRRLET ELDGLRYYVE DSLDVLYEKW FYCKDLGTQL 180 APIIQEFFRS EQYRTGKPIP EQLLKEPPFP LSTRPVMEPM SLEAWLDSHR SQLQAGTPLS 240 LFGDTYETQV TAHGHGNSQG PRLDVDVWLW QLEGSSVVMM GDKRLSLSPD DSLLVPAGTA 300 YVWERAQGSV ALSVTQDPAC KKALE 325 |
Abbreviation :
CLO : cleft lip only. CPO : cleft palate only.
CLP : cleft lip and palate. CL/P : cleft lip with/without cleft palate.
For humans: CL/P, CLO, CPO, and CLP. For mice: CLO, CLP, and CPO.
| Relation | Gene symbol | Entrez ID | UniProt ID | Cleft type | Developmental stage | Species | Evidence | Details |
|---|---|---|---|---|---|---|---|---|
| 1:1 ortholog | HAAO | 510602 | Q0VCA8 | Bos taurus | Prediction | More>> | ||
| 1:1 ortholog | HAAO | 102187775 | A0A452EKB2 | Capra hircus | Prediction | More>> | ||
| 1:1 ortholog | HAAO | 23498 | P46952 | Homo sapiens | Prediction | More>> | ||
| 1:1 ortholog | Haao | 107766 | Q78JT3 | CPO | Mus musculus | Publication | More>> | |
| 1:1 ortholog | HAAO | 737730 | A0A2I3TGC8 | Pan troglodytes | Prediction | More>> | ||
| 1:1 ortholog | HAAO | G1TAA6 | Oryctolagus cuniculus | Prediction | More>> | |||
| 1:1 ortholog | Haao | A0A0G2JSV5 | Rattus norvegicus | Prediction | More>> | |||
| 1:1 ortholog | haao | 492518 | F1QYC7 | Danio rerio | Prediction | More>> |
| GO ID | GO Term |
|---|---|
| GO:0005623 | cell |
| GO:0005829 | cytosol |
| GO:0000334 | 3-hydroxyanthranilate 3,4-dioxygenase activity |
| GO:0008198 | ferrous iron binding |
| GO:0034354 | 'de novo' NAD biosynthetic process from tryptophan |
| GO:0043420 | anthranilate metabolic process |
| GO:0070050 | neuron cellular homeostasis |
| GO:0019805 | quinolinate biosynthetic process |
| GO:0046686 | response to cadmium ion |
| GO:0010043 | response to zinc ion |
| GO:0006569 | tryptophan catabolic process |
| Pfam ID | Pfam Term |
|---|---|
| PF06052 | 3-HAO |