| Tag | Content |
|---|---|
| Uniprot ID | F1QYC7 |
| Entrez ID | 492518 |
| Genbank protein ID | |
| Genbank nucleotide ID | XM_005156599.3; XM_005156600.3; |
| Ensembl protein ID | ENSDARP00000091014; ENSDARP00000131748; |
| Ensembl nucleotide ID | ENSDARG00000076487 |
| Gene name | 3-hydroxyanthranilate 3,4-dioxygenase |
| Gene symbol | haao |
| Organism | Danio rerio |
| NCBI taxa ID | 7955 |
| Cleft type | |
| Developmental stage | |
| Data sources | Homology search |
| Reference | |
| Functional description | Catalyzes the oxidative ring opening of 3-hydroxyanthranilate to 2-amino-3-carboxymuconate semialdehyde, which spontaneously cyclizes to quinolinate. |
| Sequence | MTNQSLHVNI DKWIAENETS FLPPVCNKLM FFYQLNIMYV GGPNVRKDYH IEEGEELFYQ 60 VRGDMVLKVI ENGKHKDVHI REGEMFLLPA RIPHSPQRQA NTVGLVVERR RLSKETDGLR 120 YFVANSTEVL FERWFYCENL GTQLVPIIKE FLDSKENETG KPDPANPIKP APYPLNTMNV 180 MTPFSFREWV EKQKPVLASG CPVDMFGEQF ETETLLFGSG TSANKRRTDG WIWQLEGLSN 240 VFMNGKEYSL SAGDCLLIFG ETEYKWQRSQ DCVALYVAQD PDRKRPY 287 |
Abbreviation :
CLO : cleft lip only. CPO : cleft palate only.
CLP : cleft lip and palate. CL/P : cleft lip with/without cleft palate.
For humans: CL/P, CLO, CPO, and CLP. For mice: CLO, CLP, and CPO.
| Relation | Gene symbol | Entrez ID | UniProt ID | Cleft type | Developmental stage | Species | Evidence | Details |
|---|---|---|---|---|---|---|---|---|
| 1:1 ortholog | HAAO | 510602 | Q0VCA8 | Bos taurus | Prediction | More>> | ||
| 1:1 ortholog | HAAO | 102187775 | A0A452EKB2 | Capra hircus | Prediction | More>> | ||
| 1:1 ortholog | HAAO | 23498 | P46952 | Homo sapiens | Prediction | More>> | ||
| 1:1 ortholog | Haao | 107766 | Q78JT3 | CPO | Mus musculus | Publication | More>> | |
| 1:1 ortholog | HAAO | 737730 | A0A2I3TGC8 | Pan troglodytes | Prediction | More>> | ||
| 1:1 ortholog | HAAO | G1TAA6 | Oryctolagus cuniculus | Prediction | More>> | |||
| 1:1 ortholog | Haao | A0A0G2JSV5 | Rattus norvegicus | Prediction | More>> | |||
| 1:1 ortholog | haao | 492518 | F1QYC7 | Danio rerio | Prediction | More>> |
| GO ID | GO Term |
|---|---|
| GO:0005737 | cytoplasm |
| GO:0000334 | 3-hydroxyanthranilate 3,4-dioxygenase activity |
| GO:0008198 | ferrous iron binding |
| GO:0034354 | 'de novo' NAD biosynthetic process from tryptophan |
| GO:0043420 | anthranilate metabolic process |
| GO:0019805 | quinolinate biosynthetic process |
| GO:0006569 | tryptophan catabolic process |
| Pfam ID | Pfam Term |
|---|---|
| PF06052 | 3-HAO |